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What Is Histocompatibility Testing and How Is It Done?

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Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients

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Abstract

The purpose of immunogenetic testing in kidney transplantation is to minimize post-transplant acute rejection episodes and to decrease the intensity of chronic rejection. To the degree that the kidney donor is mismatched with the recipient there will be an increased number of targets for both the cellular and humoral immune responses. To the degree that the recipient has been sensitized against donor antigens, there will be greater risk for rejection episodes. This chapter is an exposition of what histocompatibility testing is and how it is done.

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Author information

Authors and Affiliations

  1. Renal Division, Tissue Typing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA

    Edgar L. Milford MD

  2. Renal Division, HLA Laboratory, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA

    Indira Guleria PhD

Authors
  1. Edgar L. Milford MD
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  2. Indira Guleria PhD
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Corresponding author

Correspondence to Edgar L. Milford MD .

Editor information

Editors and Affiliations

  1. Scripps Research Institute, N.Torrey Pines Rd. 10550, La Jolla, 92037, USA

    Dianne B. McKay

  2. Division of Transplantation, Sharp Memorial Hospital, Frost Street 7910, San Diego, 92123, USA

    Steven M. Steinberg

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© 2010 Springer-Verlag US

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Milford, E.L., Guleria, I. (2010). What Is Histocompatibility Testing and How Is It Done?. In: McKay, D., Steinberg, S. (eds) Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1690-7_4

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  • DOI: https://doi.org/10.1007/978-1-4419-1690-7_4

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-1689-1

  • Online ISBN: 978-1-4419-1690-7

  • eBook Packages: MedicineMedicine (R0)

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