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Advances in TNF Family Research pp 53–61Cite as

Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

Session 8 of TNF2009 focused on the function of the RING containing proteins TRAF2 and cIAPs in TNF signaling. TNF-R1 signaling is understood to be carefully balanced between a pro-survival and pro-apoptotic response and, as might be expected for proteins containing these E3 ligase domains, much of the data and discussion revolved around the regulation of these alternative pathways by ubiquitylation. The session was also notable for talks that extended dramatically our understanding of regulation of other signaling pathways by cIAPs such as necrosis and immune responses. Furthermore there was thought provoking data looking at the role of the RIP kinase family in TNF signaling and the role they play in non-apoptotic cell death pathways initiated by TNF.

Two paths diverged in a wood, and I—

I took the one less traveled by,

Oh, I kept the first for another day!

Yet knowing how way leads on to way,

I doubted if I should ever come back.

With apologies to Robert Frost

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Author information

Authors and Affiliations

  1. Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC, 3086, Australia

    John Silke

  2. Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA

    Domagoj Vucic

  3. Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, 94080, USA

    Domagoj Vucic

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  1. John Silke
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  2. Domagoj Vucic
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Correspondence to John Silke or Domagoj Vucic .

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Editors and Affiliations

  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Silke, J., Vucic, D. (2011). Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs . In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_6

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