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IL-17-Producing γδ T Cells in Auto-immune Disease

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TH17 Cells in Health and Disease

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Abstract

In both mice and humans, γδ T cells often represent a significant source of IL-17. Here we review the evidence that IL-17-producing γδ T cells contribute to auto-immune disease and discuss the role that they play in disease processes, including their influence on the development or activity of TH17 αβ T cells. Although IL-17-producing γδ T cells clearly can exacerbate auto-immune disease, in some systems they have instead been shown to play a protective role. The ability to produce IL-22 as well may be critical for this protective role.

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Authors and Affiliations

  1. Integrated Department of Immunology, National Jewish Health, 1400 Jackson St., Denver, CO, 80206, USA

    Rebecca L. O’Brien

  2. University of Colorado Denver, Aurora, CO, 80045, USA

    Rebecca L. O’Brien

Authors
  1. Rebecca L. O’Brien
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  2. Philip L. Simonian
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  3. Yafei Huang
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  4. Christina L. Roark
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  5. Niyun Jin
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  6. M. Kemal Aydintug
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  7. Jennifer L. Chain
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  8. Andrew P. Fontenot
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  9. Willi K. Born
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Corresponding author

Correspondence to Rebecca L. O’Brien .

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Editors and Affiliations

  1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, WC2R 2LS, United Kingdom

    Shuiping Jiang

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O’Brien, R.L. et al. (2011). IL-17-Producing γδ T Cells in Auto-immune Disease. In: Jiang, S. (eds) TH17 Cells in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9371-7_28

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