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Corticotropin Releasing Factor (Hormone): Physiological and Clinical Implications

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Neuroendocrine Perspectives

Part of the book series: Neuroendocrine Perspectives ((NEUROENDOCRINE,volume 7))

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Abstract

In 1948, Harris suggested the possibility of humoral control of the pituitary gland by the hypothalamus (1–3). Saffran and Schally (4), and Guillemin and Rosenberg (5) demonstrated the presence of a hypothalamic corticotropin releasing (CRF) factor in 1955. Vale and coworkers isolated ovine CRF (oCRF) in 1981 (6). Shortly thereafter, Schally et al. described the composition of porcine CRF (pCRF) (7), and Rivier et al. that of rat CRF (rCRF) (8). Finally, the genes of both ovine and human CRF (hCRF) were sequenced and the amino acid composition of the corresponding peptides deduced (9,10). Rat and human CRF appear to be chemically identical. The structures of oCRF and hCRF (or rCRF) are shown in Figure 1. Human CRF differs from the oCRF molecule by 7 amino acids, giving the two peptides 83% homology.

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Authors
  1. George P. Chrousos
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  2. Robert Udelsman
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  3. Philip W. Gold
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  4. Andrew N. Margioris
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  5. Edward H. Oldfield
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  6. Thomas H. Schürmeyer
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  7. Heinrich M. Schulte
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  8. John Doppman
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  9. D. Lynn Loriaux
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Milan, School of Medicine, 20129, Milan, Italy

    Eugenio E. Müller

  2. Department of Internal Medicine, University of Virginia, School of Medicine, 22908, Charlottesville, Virginia, USA

    Robert M. MacLeod

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© 1989 Springer-Verlag New York, Inc.

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Chrousos, G.P. et al. (1989). Corticotropin Releasing Factor (Hormone): Physiological and Clinical Implications. In: Müller, E.E., MacLeod, R.M. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3554-5_2

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  • DOI: https://doi.org/10.1007/978-1-4612-3554-5_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8155-9

  • Online ISBN: 978-1-4612-3554-5

  • eBook Packages: Springer Book Archive

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