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Tissue Engineering of Bone

  • Chapter
Synthetic Biodegradable Polymer Scaffolds

Abstract

Bone is a dynamic, highly vascularized tissue with the unique capacity to heal and to remodel depending on line of stress (Buckwalter et al, 1995ab). It exhibits the unlikely combination of high compressive strength and tensile strength due to the composite of calcium phosphate salts (hydroxyapatite) and collagen, respectively (Yaszemski et al, 1996a). It is difficult to find materials to mimic such a complex system when filling bone defects. However, current research capitalizes on the dynamic properties of bone by providing a biodegradable scaffold to guide healing.

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Author information

Authors and Affiliations

  1. Cox Laboratory for Biomedical Engineering, Institute of Biosciences and Bioengineering and Department of Chemical Engineering, Rice University, P.O. Box 1892, 77251-1892, Houston, TX, USA

    Rebekah D. Bostrom BA & Antonios G. Mikos PhD, T.N. Law Associate Professor

Authors
  1. Rebekah D. Bostrom BA
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  2. Antonios G. Mikos PhD, T.N. Law Associate Professor
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Editor information

Editors and Affiliations

  1. Laboratory for Tissue Engineering, Division of Urology and Department of Surgery, Children’s Hospital and Harvard Medical School, 300 Longwood Avenue, 02115, Boston, MA, USA

    Anthony Atala MD (Director) (Director)

  2. Departments of Biologic and Materials Sciences and Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USA

    David J. Mooney PhD

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© 1997 Birkhäuser Boston

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Bostrom, R.D., Mikos, A.G. (1997). Tissue Engineering of Bone. In: Atala, A., Mooney, D.J. (eds) Synthetic Biodegradable Polymer Scaffolds. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4154-6_12

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  • DOI: https://doi.org/10.1007/978-1-4612-4154-6_12

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8677-6

  • Online ISBN: 978-1-4612-4154-6

  • eBook Packages: Springer Book Archive

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