Skip to main content

Compliance with Menopausal Hormone Replacement Therapy

  • Chapter
Comprehensive Management of Menopause

Abstract

Implicit in this statement is the fact that we may devise efficacious forms of menopausal hormone replacement therapy (HRT) and yet the desired benefits may not be achieved because other factors result in noncompliance. Although the magnitude and pervasiveness of noncompliance with menopausal HRT has generally been acknowledged, this issue has played a limited role in assessment, decision making, policy setting, and individual patient care.1 This chapter examines the range of issues that may have an impact upon the two components of compliance—commencement and maintenance. In general, these can be divided into three major categories: physicians’ concerns, patients’ concerns, and third party concerns. The current state of compliance with available menopausal HRT regimens will be reviewed and recommendations given that may lead to improvement of utilization for those in whom HRT is deemed appropriate.

Treatment based on what is efficacious may substantially differ from treatment based on what is effective.

Speroff, et al.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Speroff T, Dawson NV, Speroff L, Haber RJ. A risk-benefit analysis of elective bilateral oophorectomy: effect of changes in compliance with estrogen therapy on outcome. Am J Obstet Gynecol. 1991; 164: 165.

    PubMed  CAS  Google Scholar 

  2. Ravnikar VA. Compliance with hormone therapy. Am J Obstet Gynecol. 1987; 154: 1332.

    Google Scholar 

  3. Bartlett EE. Patient counselling for osteoporosis prevention. In: Proceedings of the National Conference on Women’s Health Series, Special Topic Conference on Osteoporosis. J US Public Health Service. 1989;Suppl SeptOct:87.

    Google Scholar 

  4. Norris JA. Welcoming remarks. In: Proceedings of the National Conference on Women’s Health Series, Special Topic Conference on Osteoporosis. J US Public Health Service. 1989;Suppl Sept—Oct:7–8.

    Google Scholar 

  5. Ross RK. Progestogens and the cardiovascular system. Int Proc J. 1989; 1: 218.

    Google Scholar 

  6. Henderson BE, Ross RL, Lobo R, Pike MC, Mack TM. Reevaluating the role of progestogen therapy after the menopause. Fertil Steril. 1988; 49 (Suppl 5): 95.

    Google Scholar 

  7. Reid RL. Progestins in the menopause: good news and bad news. J SOCG (Can). 1990; 12 (9): 31.

    Google Scholar 

  8. Holtzman GB, Ravitch MM, Metheny W, et al. Physicians’ judgments about estrogen replace ment therapy for menopausal women. Obstet Gynecol. 1984; 71: 39.

    Google Scholar 

  9. Ferguson KJ, Hoegh C, Johnson S. Estrogen replacement therapy: a survey of women’s knowledge and attitudes. Arch Int Med. 1989; 149: 133.

    Article  CAS  Google Scholar 

  10. Notelovitz M. Hormonal therapy in climac teric women and its socioeconomic impact. In: Proceedings of the National Conference on Women’s Health Series, Special Topic Confer ence on Osteoporosis. J US Public Health Service. 1989; Suppl Sept-Oct:70–75.

    Google Scholar 

  11. Armstrong B. Oestrogen therapy after the menopause- boon or bane? Med J Aust. 1988; 213. 148; 213.

    Google Scholar 

  12. Ettinger B. Optimal use of postmenopausal hormone replacement. Obstet Gynecol. 1988; 72 (Suppl): 31.

    Google Scholar 

  13. Hahn RG, Nachtigall RD, Davis TC. Compli ance difficulties with progestin-supplemented estrogen replacement therapy. J Fam Pract. 1984; 18: 411.

    PubMed  CAS  Google Scholar 

  14. Hahn RG. Compliance considerations with estrogen replacement: withdrawal bleeding and other factors. Am J Obstet Gynecol. 1989; 161:1854. 15. Magos AL, Brincat M, Studd JWW, et al. Amenorrhea and endometrial atrophy with continuous oral estrogen and progestogen therapy in postmenopausal women. Obstet Gynecol. 1985; 65: 496.

    Google Scholar 

  15. Magos AL, Brincat E, Singh R, O’Dowd T, Brincat M, Studd JWW. The effects of norethi premenstrual syndrome. Br J Obstet Gynecol. 1986; 93: 1290

    Article  CAS  Google Scholar 

  16. Kirkham C, Hahn PM, Van Vugt DA, Car- michael JA, Reid RL. A randomized double- blind, placebo-controlled, cross-over trial to assess the side effects of medroxyprogesterone acetate in hormone replacement therapy. Ob- stet Gynecol. 1991;78(1).

    Google Scholar 

  17. Steiner M, Haskett RF, Carroll BJ. Premen strual tension syndrome: the development of research diagnostic criteria and new rating scales. Acta Psychiatr Scand. 1980; 62: 177 190.

    Google Scholar 

  18. Beck AT, Ward CH, Mendelson M, Mock J, Erbaught J. An inventory measuring depres-sion. Arch Gen Psychiatr. 1961; 4: 561–571.

    Article  PubMed  CAS  Google Scholar 

  19. Bell SA. Premenstrual syndrome and the med-icalization of the menopause. In: Ginsburg BE, Carter BF eds. Premenstrual Syndrome.New York: Plenum Press; 1987: 151–174.

    Google Scholar 

  20. Ross RK, Paganini-Hill A, Mack TM, Arthur M, Henderson BE. Menopausal oestrogen therapy and protection from death from ischaemic heart disease. Lancet. 1981; 1: 858.

    Article  PubMed  CAS  Google Scholar 

  21. Stampfer MJ, Willet WC, Colditz GA, Rosner B, Speizer FE, Hennekens CH. A prospective study of postmenopausal estrogen therapy and coronary heart disease. N Engl J Med. 1985; 313: 1044.

    Article  PubMed  CAS  Google Scholar 

  22. Paganini-Hill A, Ross Rk, Gerkins VR, Hen- derson BE, Arthur M, Mack TM. Menopausal estrogen therapy and hip fractures. Ann In- tern Med. 1981; 95: 28.

    CAS  Google Scholar 

  23. Kaufman DW, Miller DR, Rosenberg L, et al. Noncontraceptive estrogen use and risk of breast cancer. JAMA. 1984; 252: 63.

    Article  PubMed  CAS  Google Scholar 

  24. Kelsey JL, Fischer DB, Holford TR, et al. Exogenous estrogens and other factors in the epidemiology of breast cancer. JNCI. 1981; 67: 327.

    PubMed  CAS  Google Scholar 

  25. Hiat RA, Bawal R, Friedman GD, Hoover R. Exogenous estrogen and breast cancer after bilateral oophorectomy. Cancer. 1980; 54: 139.

    Article  Google Scholar 

  26. Brinton LA, Hoover RN, Szklo M, Fraumeni JF. Menopausal estrogen use and risk of breast cancer. Cancer. 1981; 47: 2517.

    Google Scholar 

  27. Dennerstein L, Wood C, Burrows GD. Sexual response following hysterectomy and oophor- ectomy. Obstet Gynecol. 1977; 49: 92.

    PubMed  CAS  Google Scholar 

  28. Ritterband AB, Jaffe IA, Densen PM, Magagna sterone in postmenopausal women on estro- gen replacement therapy: a model for the JF, Reed E. Gonadal function and the develop-ment of coronary heart disease. Circulation.

    Google Scholar 

  29. Rosenberg L, Slone D, Shapiro S, Kaufman D,1963;27:237. Stolley PD, Miettinen OS. Noncontraceptive estrogens and myocardial infarction in young women. JAMA. 1980; 244: 339.

    Article  PubMed  CAS  Google Scholar 

  30. Washnich R, Yano K, Vogel J. Postmeno-pausal bone loss at multiple skeletal site: relationship to estrogen use. J Chronic Dis. 1983; 36: 781.

    Article  Google Scholar 

  31. Weiss NS, Ure CL, Ballard JH, Williams AR,use of estrogen. N Engl J Med. 1195, 1980. Daling JR. Decreased risk of fractures of the hip and lower forearm with postmenopausal

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Jamieson, M.A., Reid, R.L. (1994). Compliance with Menopausal Hormone Replacement Therapy. In: Lorrain, J., Plouffe, L., Ravnikar, V.A., Speroff, L., Watts, N.B. (eds) Comprehensive Management of Menopause. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4330-4_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4330-4_29

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8737-7

  • Online ISBN: 978-1-4612-4330-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics