Abstract
Studies focusing on specific components of the blood vessel wall have yielded an important secret of how the “microenvironment” can control large and small artery diameter. As a result of the now classic discovery of endothelium-derived relaxing factor (EDRF) by Furchgott and Zawad-zki (1980), any discussion of the physiology or pathology of vascular reactivity must consider the integrity and function of the cells lining the intimal surface.
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References
Angus, J. A. and Cocks, T. M.: Role of endothelium in vascular responses to norepinephrine, serotonin and acetylcholine. Bibl. Cardiol. 38: 43–52, 1984.
Angus, J. A., Campbell, G. R., Cocks, T. M., and Manderson, J. A.: Vasodilatation by acetylcholine is endothelium-dependent: A study by sonomicrometry in canine femoral artery in vivo. J. Physiol. (Lond.) 344: 209–222, 1983.
Angus, J. A., Cocks, T. M., and Satoh, K.: Alpha-adrenoceptors and endothelium-dependent relaxation in canine large arteries. Br. J. Pharmacol. 88: 767–777, 1986a.
Angus, J. A., Cocks, T. M., and Satoh, K. Alpha-adrenoceptors on endothelial cells. Fed. Proc. 45: 2355–2359, 1986b.
Angus, J. A., Wright, C. E., Cocks, T. M., Satoh, K., and Campbell, G.: Endothelium-dependent relaxation is unaltered by hypertension, cholesterol or intimai thickening. Clin. Exp. Pharmacol. Physiol. 13: 289–293, 1986c.
Clowes, A. W., Reidy, M. A., and Clowes, M. M.: Kinetics of cellular proliferation after arterial injury. 1. Smooth muscle cell growth in the absence of endothelium. Lab. Invest. 49: 327–333, 1983.
Cocks, T. M. and Angus, J. A.: Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305: 627–630, 1983.
Coene, M.-C, Herman, A. G., Jordaens, F., Van Hove, C, Verbeuren, T. J., and Zonnekeyn, L.: Endothelium-dependent relaxations in isolated arteries of control and hypercholesterolemic rabbits. Br. J. Pharmacol. 85: 267P, 1985.
Cohen, R. A., Shepherd, J. T., and Vanhoutte, P. M.: 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. Am. J. Physiol. 245: H1077–H1080, 1983.
Furchgott, R. F. and Zawadzki, J. V.: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature (Lond.) 288: 373–376, 1980.
Herd, J. A. and Barger, A. C: Simplified technique for chronic catheterization of blood vessels. J. Appl. Physiol. 19: 791–792, 1964.
Holtz, J., Forsterman, U., Pohl, U., Giesler, M., and Bassenge, E.: Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: Effects of cyclooxygenase inhibition. J. Cardiovas. Pharmacol. 6: 1161–1169, 1984.
Lamping, K., Marcus, M. L., and Dole, W. P.: Removal of the endothelium potentiates canine large coronary artery constrictor responses to 5-hydroxy-tryptamine in vivo. Circ. Res. 57: 46–54, 1985.
Mulvany, M. J. and Halpern, W.: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41: 19–26, 1977.
Rapoport, R. M. and Murad, F.: Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 52: 352–357, 1983.
Wright, C. E. and Angus, J. A.: Effects of hypertension and hypercholesterolemia on vasodilatation in the rabbit. Hypertension 8: 361–371, 1986.
Wright, C. E., Angus, J. A., and Korner, P. I.: Vascular amplifier properties in renovascular hypertension in conscious rabbits: Hindquarter responses to constrictor and dilator stimuli. Hypertension 9: 122–131, 1987.
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Angus, J.A., Cocks, T.M., Wright, C.E., Satoh, K., Campbell, G.R. (1988). Endothelium-Dependent Responses in Large Arteries and in the Microcirculation. In: Vanhoutte, P.M. (eds) Relaxing and Contracting Factors. The Endothelium. Humana Press. https://doi.org/10.1007/978-1-4612-4588-9_18
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DOI: https://doi.org/10.1007/978-1-4612-4588-9_18
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