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Multiple Biological Activities of Human Interleukin-1

  • Chapter
Molecular Basis of Lymphokine Action

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 18))

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Abstract

Interleukin-1 (IL-1) is a polypeptide product of various cells which mediates host responses to infection and injury. Its most dramatic biological property is its ability to induce arachidonate metabolites in a variety of cells including PGE-2 in brain, fibroblasts, synovial cells and chrondrocytes; in addition, IL-1 induces lipoxygenase products in lymphocytes and other cells. In order to fight life-threatening microbial invasion or localize tissue injury, mammals have developed a large number of varied responses which signal the onset of disease and trigger appropriate defensive measures. The responses are called “acute phase” responses because they are often observed within hours following the injury or initiation of infection. The metabolic and hematological responses can be substantial and are frequently costly to the host especially when they persist and become chronic components of the disease. IL-1 is one of the body’s key mediators of acute responses to microbial invasion, inflammation, immunological reaction and tissue injury.

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Author information

Authors and Affiliations

  1. Department of Medicine, New Engl Med Center Hospital, Tufts University School of Medicine, 750 Washington St, Boston, MA, 02111, USA

    Charles A. Dinarello

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  1. Charles A. Dinarello
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Editor information

Editors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, USA

    David R. Webb

  2. Jewish Hospital, Washington University, St. Louis, USA

    Carl W. Pierce

  3. University of Connecticut, Farmington, Connecticut, USA

    Stanley Cohen

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© 1987 The Humana Press Inc.

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Dinarello, C.A. (1987). Multiple Biological Activities of Human Interleukin-1. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_8

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  • DOI: https://doi.org/10.1007/978-1-4612-4598-8_8

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8943-2

  • Online ISBN: 978-1-4612-4598-8

  • eBook Packages: Springer Book Archive

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