Abstract
Cell-mediated immunity (CMI) is concerned with the elimination of foci of virus growth from tissues [1]. The basic need is to prevent the progressive spread of the infectious process, which would eventually result in compromised organ function and death. Effector thymus-derived lymphocytes (T cells), the operators of CMI, interact with target cells that are supporting virus replication and are thus expressing surface changes seen as nonself. This focusing of virus-immune lymphocytes onto virus-infected cells reflects that T-cell function can only be mediated via recognition of neoantigen (virus) in the context of self major histocompatibility (MHC) determinants [2].
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© 1984 Springer-Verlag New York Inc.
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Doherty, P.C., Zinkernagel, R.M. (1984). MHC Restriction and Cytotoxic T Lymphocytes. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_8
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_8
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