Abstract
Hunger is a psychological construct, usually operationally defined as being directly proportional to hours of food deprivation (Silverstone, 1976), but assumed to be a neurophysiological reality. As with most psychological constructs, however, the neural substrates representing hunger have yielded slowly to neurophysiological analysis. This resistance to reductionistic assaults stems from oversimplifying the problem in the first place, and then trying to locate the oversimplification within the brain. Although neither oversimplification has been eliminated, both are now recognized, and this recognition has diverted scientific energy from the frontal assault on the hypothalamus initiated in Ranson’s laboratory and led by John Brobeck and his colleagues almost 40 years ago (Brobeck, Tepperman, & Long, 1943; Anand & Brobeck, 1951; Hetherington & Ranson, 1940) into subsidiary investigations aimed at deciphering hunger variables and integrating psychological concepts into neurophysiological analysis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Reference
Anand, B. K., & Brobeck, J. R. Hypothalamic control of food intake in rats and cats. Yale Journal of Biology and Medicine, 1951, 24, 123–140.
Anand, B. K., Chhina, G. S., Sharma, K. N., Dua, S., & Singh, B. Activity of single neurons in the hypothalamic feeding centers: Effect of glucose. American Journal of Physiology, 1964, 207, 1146–1154.
Ashe, J. H., & Nachman, M. Neural mechanisms in taste aversion learning. In E. Stellar & A. Epstein (Eds.), Progress in psychobiology and physiological psychology (Vol. 9). New York: Academic Press, 1980.
Astrom, K. E. On the central course of afferent fibers in the trigeminal, facial, glossopharyngeal, and vagal nerves in their nuclei in the house. Acta Physiologica Scandinavica, 1953, 29, 206–320 (Supp. 106).
Ball, G. Vagotomy: Effect on electrically elicited eating and self-stimulation in the lateral hypothalamus. Science, 1974, 184, 484–485.
Bard, P., & Macht, M. B. The behavior of chronically decerebrate cats. In Ciba Foundation symposium on the neurological bases of behavior. London: Churchill, 1958.
Beckstead, R., & Norgren, R. An autoradiographic examination of the central distribution of the trigeminal, facial, glossopharyngeal, and vagal nerves in the monkey. Journal of Comparative Neurology, 1979, 184, 455–472.
Berridge, K., Grill, H. J., & Norgren, R. The relation of consummatory responses and preabsorptive insulin release to palatability and learned taste aversions. Journal of Comparative and Physiological Psychology, 1981, 95, 363–382.
Braun, J. J. Neocortex and feeding behavior in the rat. Journal of Comparative and Physiological Psychology, 1975, 89, 507–522.
Brobeck, J. R., Tepperman, J., & Long, C. N. H. Experimental hypothalamic hyperphagic in the albino rat. Yale Journal of Biology and Medicine, 1943, 15, 831–853.
Chase, M. H., & McGinty, D. J. Modulation of spontaneous reflex activity of the jaw musculature by orbital cortical stimulation in the freely-moving cat. Brain Research, 1970, 19, 117–126.
Demente, C. D., Sutin, J., & Silverstone, J. T. Changes in electrical activity of the medulla on the intravenous injection of hypertonic solutions. American Journal of Physiology, 1957, 188, 193–198.
Coil, J., & Norgren, R. Cells of origin of motor axons in the subdiaphragmatic vagus of the rat. Journal of the Autonomic Nervous System, 1979, 1, 203–210.
Coil, J. D., & Norgren, R. Taste aversions conditioned with intravenous copper sulfate: Attenuation by ablation of the area postrema. Brain Research, 1981, 212, 425–433.
Coil, J. D., Rogers, R., Garcia, J., & Novin, D. Conditioned taste aversions: Vagal and circulatory mediation of the toxic US. Behavioral Biology, 1978, 24, 509–519.
Cole, S. O. Changes in the feeding behavior of rats after amygdala lesions. Behavioral Biology, 1974, 12, 265–270.
Coons, E. E. Motivational correlates of eating elicited by electrical stimulation in the lateral hypothalamic feeding areas. Unpublished doctoral dissertation, Yale University, 1964.
Coons, E. E., Levak, M., & Miller, N. E. Lateral hypothalamus: Learning of food-seeking response motivated by electrical stimulation. Science, 1965, 150, 1320–1321.
Craig, W. Appetites and aversions as constituents of instincts. Biological Bulletin, 1918, 34, 91–107.
DiRocco, R. J., & Grill, H. J. The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation. Science, 1979, 204, 1112–1114.
Doty, R. W. Neural organization of deglutition. In C. F. Code & C. L. Prosser (Eds.), Handbook of physiology, Section 6: Alimentary canal (Vol. 4). Washington, D.C.: American Physiological Society, 1968.
Fitzsimons, J. Thirst. Physiological Reviews, 1972, 52, 468–561.
Fluharty, S. J. & Grill, H. J. Taste reactivity of lateral hypothalamic lesioned rats: Effects of deprivation and tube feeding. Society for Neuroscience Abstracts, 1981, 7, 28.
Flynn, J. P. Patterning mechanisms, patterned reflexes, and attack behavior in cats. In J. K. Cole & D. D. Jensen (Eds.), Nebraska Symposium on Motivation (Vol. 20). Lincoln: University of Nebraska Press, 1972.
Flynn, J. P., Edwards, S. B., & Bandler, R. J., Jr. Changes in sensory and motor systems during centrally elicited attack. Behavioral Sciences, 1971, 16, 1–19.
Fonberg, E. Amygdala functions within the alimentary system. Acta Neurobiologiae Experimentalis, 1974, 34, 435–466.
Friedman, M., & Stricker, E. The physiological psychology of hunger: A physiological perspective. Psychological Review, 1976, 83, 409–431.
Fuxe, K. Evidence for the existence of monoamine neurons in the central nervous system, IV: Distribution of monoamine nerve terminals in the central nervous system. Acta Physiologica Scandinavica, 1965, 64, 37–85.
Freed, E. K., & Grill, H. J. Levels of function in rat grooming behavior. Society for Neuroscience Abstracts, 1979, 5, 468.
Glickman, E., & Schiff, B. B. A biological theory of reinforcement. Psychological Review, 1967, 74, 81–109.
Grill, H. J. Sucrose as an aversive stimulus. Society for Neuroscience Abstracts, 1975, 1, 525.
Grill, H. J. Production and regulation of ingestive consummatory behavior in the chronic decerebrate rat. Brain Research Bulletin, 1980, 5, 79–87.
Grill, H. J., & Miselis, R. R. Lack of ingestive compensation to osmotic stimuli in chronic decerebrate rats. American Journal of Physiology, 1981, 240, R81–86.
Grill, H. J., & Norgren, R. Chronic decerebrate rats demonstrate satiation, but not baitshyness. Science, 1978, 201, 267–269. (a)
Grill, H. J., & Norgren, R. Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats. Brain Research, 1978, 143, 299–312. (b)
Grill, H. J., & Norgren, R. The taste reactivity test, I: Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Research, 1978, 143, 263–279. (c)
Grill, H. J., & Norgren, R. The taste reactivity test, II: Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats. Brain Research, 1978, 143, 281–297. (d)
Grossman, S. Role of the hypothalamus in the regulation of food and water intake. Psychological Review, 1975, 82, 200–224.
Haberich, F. Osmoreception in the portal circulation. Federation Proceedings, 1968, 27, 1137–1141.
Hess, W. R. The functional organization of the diencephalon. New York: Grune & Stratton, 1958.
Hetherington, A. W., & Ranson, S. W. Hypothalamic lesions and adiposity in the rat. Anatomical Record, 1940, 78, 149–172.
Hetherington, A., & Ranson, S. Effect of early hypophysectomy on hypothalamic obesity. Endocrinology, 1942, 31, 30–34.
Hiiemae, K., & Ardran, G. A cinefluorographic study of mandibular movement during feeding in the rat (Rattus norvegicus). Journal of Zoology (London), 1968, 154, 139–154.
Hinde, R. A. Animal behaviour: A synthesis of ethology and comparative psychology (2nd ed.). New York: McGraw-Hill, 1970.
Hoebel, B. G. Feeding and self-stimulation. Annals of the New York Academy of Sciences, 1969, 157, 758–778.
Hoebel, B. G., & Teitelbaum, P. Hypothalamic control of feeding and self-stimulation. Science, 1962, 135, 375–377.
Kaada, B. R. Stimulation and regional ablation of the amygdaloid complex with reference to functional representations. In B. E. Eleftheriou (Ed.), The neurobiology of the amygdala. New York: Plenum Press, 1972.
Kolb, B., & Nonneman, A. Prefrontal cortex and the regulation of food intake in the rat. Journal of Comparative and Physiological Psychology, 1975, 88, 806–815.
Kolb, B., Whishaw, I. Q., & Schallert, T. Aphagia, behavior sequencing and body weight set point following orbital frontal lesions in rats. Physiology and Behavior, 1977, 19, 93–103.
LeMagnen, J. Habits and food intake. In C. F. Code (Ed.), Handbook of physiology, Section 6: Alimentary canal (Vol. 1, Control of food and water intake). Washington, D.C.: American Physiological Society, 1967.
LeMagnen, J., Devos, M., Gaudilliere, J.-P., Louis-Sylvestre, J., & Talion, S. Role of a lipostatic mechanism in regulation by feeding of energy balance in rats. Journal of Comparative and Physiological Psychology, 1973, 84, 1–23.
Lindvall, O., & Bjorklund, A. The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiologica Scandinavica, 1974, 1–48 (Suppl. 412).
Lund, J. P., & Dellow, P. G. Rhythmical masticatory activity of hypoglossal motoneurons responding to an oral stimulus. Experimental Neurology, 1973, 40, 243–246.
Mabry, P. D., & Campbell, B. A. Food-deprivation-induced behavioral arousal: Mediation by hypothalamus and amygdala. Journal of Comparative and Physiological Psychology, 1975, 89, 19–38.
Macht, M. B. Subcortical localization of certain “taste” responses in the cat. Federation Proceedings, 1951, 20, 88.
Margules, D., & Olds, J. Identical “feeding” and “reward” systems in the lateral hypothalamus of rats. Science, 1962, 135, 374–375.
Marshall, J., Levitan, D., & Stricker, E. Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions. Journal of Comparative and Physiological Psychology, 1976, 90, 536–546.
Marshall, J., & Teitelbaum, P. Further analysis of sensory inattention following lateral hypothalamic damage in rats. Journal of Comparative and Physiological Psychology, 1974, 86, 375–395.
Marshall, J. F., Turner, B. H., & Teitelbaum, P. Sensory neglect produced by lateral hypothalamic damage. Science, 1971, 174, 523–525.
Mayer, J. Glucostatic mechanism of regulation of food intake. New England Journal of Medicine, 1953, 249, 13–16.
Mayer, J., & Arees, E. A. Ventromedial glucoreceptor system. Federation Proceedings, 1968, 27, 1345–1348.
McFarland, D. J. Decision making in animals. Nature, 1977, 269, 15–21.
Miller, F. R., & Sherrington, C. S. Some observations on the bucco-pharyngeal stage of reflex deglutition in the cat. Quarterly Journal of Experimental Physiology, 1916, 9, 147–186.
Miller, N. E. Experiments on Motivation: Studies combining psychological, physiological, and pharmacological techniques. Science, 1957, 126, 1271–1278.
Mogenson, G. J., & Phillips, A. G. Motivation: A psychological construct in search of a physiological substrate. Progress in Psychobiology and Physiological Psychology, 1976, 6, 189–243.
Mook, D. G. Saccharin preference in the rat: Some unpalatable findings. Psychological Review, 1974, 81, 475–490.
Morgane, P. J. Alterations in feeding and drinking behavior of rats with lesions in globi pallidi. American Journal of Physiology, 1961, 201, 420–428.
Nachman, M., & Ashe, J. H. Learned taste aversions in rats as a function of dosage, concentration, and route of administration of LiCl. Physiology and Behavior, 1973, 10, 73–78.
Norgren, R. A synopsis of gustatory neuroanatomy. In J. LeMagnen and P. MacLeod (Eds.), Olfaction and taste, VI. London: Information Retrieval Ltd., 1977.
Norgren, R. Flavor and the neural organization of feeding behavior. In C. M. Apt (Ed.), Flavor: Its chemical, behavioral, and commercial aspects. Boulder: West-view Press, 1978.
Novin, D., & Oomura, Y. (Eds.). Integration of central and peripheral receptors in hunger and energy metabolism. Brain Research Bulletin, 1980, 5 (Suppl. 4).
Oomura, Y. Significance of glucose, insulin and free fatty acid on the hypothalamic feeding and satiety neurons. In D. Novin, W. Wyrwicka, & G. Bray (Eds.), Hunger: Basic mechansims and clinical implications. New York: Raven Press, 1976.
Oomura, Y., Ooyama, H., Yamamoto, T., & Naka, F. Reciprocal relationship of the lateral and ventromedial hypothalamus in the regulation of food intake. Physiology and Behavior, 1967, 2, 97–115.
Phillips, M. I., & Norgren, R. A rapid method for permanent implantation of an intraoral fistula in rats. Behavioral Research Methods and Instrumentation, 1970, 2, 124.
Powley, T. The ventromedial hypothalamic syndrome, satiety and a cephalic phase hypothesis. Psychological Review, 1977, 84, 89–126.
Powley, T., & Opshal, C. Ventromedial hypothalamic obesity abolished by subdiaphragmatic vagotomy. American Journal of Physiology, 1974, 226, 25–33.
Richter, C. P. Total self-regulatory functions in animals and human beings. Harvey Lectures, 1943, 38, 63–103.
Richter, C. P., Holt, L. E., & Bariare, B. Nutritional requirements for normal growth and reproduction in rats studied by the self-selection method. American Journal of Physiology, 1938, 122, 734–744.
Ritter, S., McGlone, J. J., & Kelley, K. W. Absence of lithium-induced taste aversion after area postrema lesion. Brain Research, 1980, 201, 501–506.
Rogers, R., Novin, D., & Butcher, L. Electrophysiological and neuroanatomical studies of hepatic portal osmo- and sodium-receptive afferent projections within the brain. Journal of the Autonomic Nervous System, 1979, 1, 183–202.
Rozin, P. Are carbohydrate and protein intakes separately regulated? Journal of Comparative and Physiological Psychology, 1968, 65, 23–29.
Rozin, P., & Kalat, J. W. Specific hungers and poison avoidance as adaptive specializations of learning. Psychological Review, 1971, 78, 459–486.
Schwartz, N., & Kling, A. The effect of amygdaloid lesions on feeding, grooming, and reproduction in rats. Acta Neuroregulation, 1964, 26, 12–34.
Sessle, B. J., & Hannam, A. G. (Eds.). Mastication and swallowing: Biological and clinical correlates. Toronto: University of Toronto Press, 1976.
Sessle, B. J., & Kenny, D. J. Control of tongue and facial motility: Neural mechanisms that may contribute to movements such as swallowing and sucking. In J. F. Bosma (Ed.), Fourth symposium on oral sensation and perception. Bethesda, Md.: USDHEW, National Institutes of Health, 1973.
Silverstone, J. T. The CNS and feeding: Group report. In Dahlem workshop on appetite and food intake. Berlin: Abakon Verlagsgesellschaft, 1976.
Sorenson, C. A., & Ellison, G. D. Striatal organization of feeding behavior in the decorticate rat. Experimental Neurology, 1970, 29, 162–179.
Stellar, E. The physiology of motivation. Psychological Review, 1954, 61, 5–22.
Storey, A. B. Laryngeal initiation of swallowing. Experimental Neurology, 1968, 20, 359–365. (a)
Storey, A. B. A functional analysis of sensory units innervating epiglottis and larynx. Experimental Neurology, 1968, 20, 366–383. (b)
Teitelbaum, P. Levels of integration of the operant. In W. K. Honig & J. E. R. Staddon (Eds.), Handbook of operant behavior. Englewood Cliffs, N. J.: Prentice-Hall, 1977.
Teitelbaum, P., & Epstein, A. N. The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions. Psychological Review, 1962, 69, 74–90.
Teitelbaum, P., Schallert, T., de Ryck, M., Whishaw, I. Q., & Golani, I. Motor subsystems in motivated behavior. In R. F. Thompson, L. H. Hicks, & V. B. Shvyrokov (Eds.), Neural mechanisms of goal-directed behavior and learning. New York: Academic Press, 1980.
Tinbergen, N. The study of instinct. Oxford, England: Clarendon Press, 1951.
Toates, F. M. Homeostasis and drinking. Behavioral and Brain Sciences, 1979, 2, 95–139.
Torvik, A. Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures: An experimental study in the rat. Journal of Comparative Neurology, 1956, 106, 51–141.
Ungerstedt, U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiologica Scandinavica, 1971, 82 (Suppl. 367). (a)
Ungerstedt, U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiologica Scandinavica, 1971, 82, 1–48 (Suppl. 367). (b)
Vanderwolf, C. H., Kolb, B., & Cooley, R. Behavior of the rat after removal of neocortex and hippocampus formation. Journal of Comparative and Physiological Psychology, 1978, 92, 156–175.
Wang, G. H., & Akert, K. Behavior and reflexes of chronic striatal cats. Archives Italiennes de Biologie, 1962, 100, 48–85.
Weijs, W. A., & Dantuma, R. Electromyography and mechanics of mastication in the albino rat. Journal of Morphology, 1975, 146, 1–34.
Wirsig, C. R. & Grill, H. J. The contribution of the rat’s neocortex to ingestive control: I. Latent learning for the taste of sodium chloride. Journal of Comparative and Physiological Psychology, 1982, in press.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Norgren, R., Grill, H. (1982). Brain-Stem Control of Ingestive Behavior. In: Pfaff, D.W. (eds) The Physiological Mechanisms of Motivation. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5692-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5692-2_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-5694-6
Online ISBN: 978-1-4612-5692-2
eBook Packages: Springer Book Archive