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The Metzincin-Superfamily of Zinc-Peptidases

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Intracellular Protein Catabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 389))

Abstract

Over the past three years, the three-dimensional structures of a number of zinc proteinases that share the zinc-binding motif HEXXHXXGXXH have been elucidated. These proteinases comprise astacin, a digestive enzyme from crayfish [1,2,3], adamalysin II [4,5] and atrolysin C [6] from snake venom, the Pseudomonas aeruginosa alkaline proteinase [7] and serralysin from Serratia marcescens proteinase [8], the collagenases from human neutrophils [9,10,11]) and fibroblasts [12,13,14,15], human stromelysin 1 [16; K. Appelt, personal communication] and matrilysin [M. Browner, Keystone Symposia, March 5–12, 1994]. These enzymes represent four different families of zinc peptidases: the astacins [3,17], the bacterial serralysins [18], the adamalysins/reprolysins [19,20], and the matrixins (matrix metalloproteinases, MMPs) [21,22].

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Author information

Authors and Affiliations

  1. Max-Planck-Institut für Biochemie, Am Klopferspitz 18, D-82152, Martinsried, Germany

    W. Bode, F. Grams, P. Reinemer & F.-X. Gomis-Rüth

  2. Institut für Organische Chemie und Biochemie, Universität Freiburg, Albertstraße 21, D-79104, Freiburg, Germany

    U. Baumann

  3. Beckman Laboratories for Structural Biology Department of Cell Biology, Stanford University School of Medicine Stanford, Stanford, California, 94305, USA

    D. B. McKay

  4. Zoologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 230, D-69120, Heidelberg, Germany

    W. Stöcker

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  1. W. Bode
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  2. F. Grams
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  3. P. Reinemer
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  4. F.-X. Gomis-Rüth
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  5. U. Baumann
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Editors and Affiliations

  1. University of Tokyo, Tokyo, Japan

    Koichi Suzuki

  2. College of Medicine, Penn State University, Hershey, Pennsylvania, USA

    Judith S. Bond

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© 1996 Plenum Press, New York

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Bode, W. et al. (1996). The Metzincin-Superfamily of Zinc-Peptidases. In: Suzuki, K., Bond, J.S. (eds) Intracellular Protein Catabolism. Advances in Experimental Medicine and Biology, vol 389. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0335-0_1

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  • DOI: https://doi.org/10.1007/978-1-4613-0335-0_1

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