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Noncomplementation Phenomena and Their Bearing on Nondisjunctional Effects

  • Chapter
Aneuploidy

Part of the book series: Basic Life Sciences ((BLSC,volume 36))

Abstract

In the mouse, unbalanced gametes with major gains and/or losses of chromosomal material seem just as capable of forming a zygote as normal, fully balanced gametes. This is shown by the results of intercrossing genetically marked translocation heterozygotes, in which complementary unbalanced gametes usually fuse to form fully viable zygotes. However, there are some notable exceptions to this. Studies on a number of reciprocal translocations have shown that gametes with maternal duplication of particular chromosome regions may fail to complement those with a corresponding paternal deficiency, but produce lethal zygotes instead, whereas the reciprocal combination of a paternal duplication with a maternal deficiency produces fully viable offspring. For a particular distal region on chromosome 7 the reverse situation holds. More recent studies on genetic methods of detecting nondisjunction with Robertsonian translocations have revealed the same phenomenon. Mouse chromosomes affected include numbers 2, 6, 7, and 8. There is also defective complementation on chromosome 11 and related phenomena on chromosome 17. These findings help to explain why diploid embryos with 2 male or 2 female pronuclei fail to come to term and may be connected with genetic imprinting of gametes. It seems probable that the same phenomenon occurs in homologous regions of human chromosomes and may mean that the severity of a trisomic effect will depend sometimes on the parental source of the extra chromosome. The phenomenon also affects the efficiency of certain genetic tests for nondisjunction which depend on full complementation.

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Authors and Affiliations

  1. Medical Research Council Radiobiology Unit, Harwell, Oxon, OX11 ORD, UK

    A. G. Searle & C. V. Beechey

Authors
  1. A. G. Searle
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  2. C. V. Beechey
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Editor information

Editors and Affiliations

  1. U.S. Environment Protection Agency, Washington, D.C, USA

    Vicki L. Dellarco  & Peter E. Voytek  & 

  2. Council for Research Planning in Biological Sciences, Inc., Washington,D.C, USA

    Alexander Hollaender

  3. University of Alabama, Birmingham, Alabama, USA

    B. R. Brinkley

  4. New York State Department of Health, Albany, New York, USA

    Ernest B. Hook

  5. Duke University School of Medicine, Durham, North Carolina, USA

    Montrose J. Moses

  6. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

  7. M. D. Anderson Hospital and Tumor Institute, Houston, Texas, USA

    T. C. Hsu

  8. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Liane B. Russell

  9. Brookhaven National Laboratory, Upton, New York, USA

    Raymond R. Tice

  10. U.S. Environmental Protection Agency Research Triagle Park, North Carolina, USA

    Michael D. Waters

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© 1985 Plenum Press, New York

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Searle, A.G., Beechey, C.V. (1985). Noncomplementation Phenomena and Their Bearing on Nondisjunctional Effects. In: Dellarco, V.L., et al. Aneuploidy. Basic Life Sciences, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2127-9_25

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  • DOI: https://doi.org/10.1007/978-1-4613-2127-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9257-9

  • Online ISBN: 978-1-4613-2127-9

  • eBook Packages: Springer Book Archive

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