Abstract
Senile systemic amyloid contains the prealbumin-like fibril protein, ASc1, and is the only known form of systemic age-related amyloid. Although it involves predominantly the heart, it may be found in a wide range of tissues. Immunologic studies show that ASc1 cross reacts with human prealbumin (PA) in binding reactions but not in immunoprecipitation reactions. Protein ASc1 shows complete homology with PA in four residues isolated. However, unlike PA, Asc1 may have a blocked N-terminus and is composed of at least three components. Anti-ASc1 forms a line of precipitation with sera from patients with familial amyloidosis. A similar weak reaction has been observed in some elderly patients with senile systemic amyloid.
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References and Notes
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Supported in part by the Swedish Medical Research Council (Project No. 5941) and the Research Fund of King Gustaf V.
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© 1986 Plenum Press, New York
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Cornwell, G.G., Westermark, P., Kyle, R.A., Pitkanen, P., Benson, L., Olofsson, BO. (1986). Senile Systemic Amyloidosis. In: Glenner, G.G., Osserman, E.F., Benditt, E.P., Calkins, E., Cohen, A.S., Zucker-Franklin, D. (eds) Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2199-6_83
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DOI: https://doi.org/10.1007/978-1-4613-2199-6_83
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