Abstract
Hydrogels elicit a low cellular adhesion in vitro when measured by platelet adhesion tests under static conditions (1,2). A thermodynamic model has been described which predicts the level of cellular adhesion and protein adsorption to a range of polymer surfaces (3,4). The aim of this model is to elucidate the possible mechanisms of cell adhesion and protein adsorption, and to use this knowledge for the development of non-thrombogenic biocompatible implant materials.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.S. Hoffman, G. Schmer, C. Harris et al. Trans. Am. Soc. Artif. Intern. Organs 18. 10, (1972).
S.D. Bruck. J. Biomed. Mat. Res. 7, 387, (1973).
D.R. Absolom, A.W. Neumann, W. Zingg et al. Trans. Am. Soc. Artif. Intern. Organs 25, 152, (1979).
A.W. Neumann, D.R. Absolom, W. Zingg, et al. Surface Thermodynamics of protein adsorption, cell adhesion and cell engulfment. in: Biocomptaible Polymers, M. Syzcher, ed. Thermo. Electron, Walton, Mass. Chapter 3, (1983).
A.W. Adamson . Physical Chemistry of Surfaces. pp 27–28, J.W. Wiley and Sons, N.Y., (1982).
A.W. Neumann, J.K. Spelt and D.R. Absolom. Measurement of the surface tensions of blood cells and other particles. Annals New York Acad. Sci. (In Press).
A.W. Neumann. Adv. Colloid Interface Sci. 4, 105, (1974).
R.C. Allen and H.R. Mauer. in: Electrophoresis and isoelectric Focussing in Polyacrylamide Gels. W. de Gruyter, New York, 1974. pp 16–27.
S. Hjerten. Arch. Biochem. Biophys. 1, 147, (1962).
O. Driedger, A.W. Neumann, and P.J. Sell. Kolloid Z.Z. Polym. 201, 52, (1965).
D.R. Absolom, D.W. Francis, W. Zingg, et al. J. Colloid Interface Sci. 85, 168, (1982).
J.F. Mustard, D.W. Perry, M.G. Ardlie et al. Brit. J. Haematol. 22. 193, (1972).
O.S. Hum, A.W. Neumann and W. Zingg. Thromb. Res. 7, 461, (1975).
A.W. Neumann, R.J. Good, C.J. Hope et al. J. Colloid Interface Sci. 49, 291, (1974).
D.R. Absolom, W. Zingg, C.J. van Oss et al. Measurement of surface tension of cells and biopolymers with application to the evaluation of biocompatibility. in: Comprehensive Biotechnology, Vol III, Chapter 23, C.W. Robinson ed., Blackwell, Oxford, In Press.
A.W. Neumann, D.R. Absolom, W. Zingg et al. Cell Biophysics, 1, 79, (1979).
D.R. Absolom, C.J. van Oss, R.J. Genco et al. Cell Biophysics 2, 113, (1980).
D.R. Absolom, W. Zingg, C. Thompson et al. Erythrocyte Adhesion to Polymer Surfaces. I. J. Colloid Interface Sci. (In Press).
D.R. Absolom, F.V. Lamberti, Z. Policova et al. J. Appld. Environ. Microbiology 46, 90, (1983).
A.W. Neumann, O.S. Hum, D.W. Francis et al. J. Biomed. Mater. Res. 14, 499, (1980).
A.W. Neumann, D.W. Franciss, W. Zingg et al. J. Biomed. Mater. Res. 17, 375, (1983).
M.F. Refojo . in: Hydrogels for Medical and Related Applications; J.D. Andrade, ed. A.C.S. Symposium Series 31, A.C.S. Washington, (1976).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Absolom, D.R., Foo, M.H., Zingg, W., Neumann, A.W. (1984). Thermodynamic Assessment of Platelet Adhesion to Polyacrylamide Gels. In: Shalaby, S.W., Hoffman, A.S., Ratner, B.D., Horbett, T.A. (eds) Polymers as Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2433-1_11
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2433-1_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9480-1
Online ISBN: 978-1-4613-2433-1
eBook Packages: Springer Book Archive