Abstract
This paper presents chemical and pharmacological data on a series of nitrogen- and sulfur-containing benzopyrans structurally and historically related to the cannabinoids. These new classes of compounds are benzopyranopyridines, thiopyranobenzopyrans, thienobenzopyrans, and their water-soluble ester derivatives. Representatives of these agents are currently under investigation in animals and man to determine their therapeutic potential.
NOTE: This presentation is based on subject matter which has been accepted for publication by the Journal of Medicinal Chemistry (see Pars and associates, 1976; Razdan and associates, 1976).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaron, M.S., & Ferguson, C.P. J. Organic Chem., 1968, 33, 684.
Adams, R., Harfenst, M., & Loewe, S. J. Amer. Chem. Soc., 1949, 71, 1624, and earlier papers cited therein.
Anker, R.M., & Cook, A.H. J. Chem. Soc., 1946, 580
Bergel, F. In G. E. W. Wolstenholme (Ed.), “Hashish: Its chemistry and pharmacology,” CIBA Foundation Study Group No. 21. London: J. & H. Churchill Ltd., 1965, 81.
Bergel, F., Morrison, A.L., Rinderknecht, H., Todd, A.R., MacDonald, A.D., & Woolfe, G. Journal of the Chemical Society, 1943, 286, and earlier papers cited therein.
Dagirmanjian, R., & Boyd, E.S. J. Pharmac. and Exp. Therap., 1962, 135, 25.
Dewey, W.L., Harris, L.S., Howes, J.F., Kennedy, J.S., Granchelli, F.E., Pars, H.G., & Razdan, R.K. Nature, 1970, 226, 1265.
Dren, A.T. Symposium on “Approaches to centrally acting drugs derived from the cannabinoid nucleus.” Presented at the 68th American Chemical Society Meeting, Atlantic City, N. J., 1974 (Abstract).
Hardman, H.F., Domino, E.F., & Seevers, M.M. Pharmacological Reviews, 1971, 23, 295.
Harris, L.S., & Dewey, W.L. Symposium on “Approaches to centrally acting drugs derived from the cannabinoid nucleus.” Presented at the 68th American Chemical Society Meeting, Atlantic City, N. J., 1974 (Abstract).
Irwin, S. In J. A. Nodine & P. E. Siegler (Eds.), “Animal and clinical pharmacologic technique in drug evaluation.” Chicago: Year Book Publishers, 1964, 36–54.
Lemberger, L., McMahon, R., Archer, R., Matsumoto, K., & Rowe, H. Clinical Pharmacology and Therapeutics, 1974, 15, 380.
Loev, B., Bender, P.E., Dowalo, F., MackoF D.E., & Fowler, P.J. Journal of Medicinal Chemistry, 1973, 16, 1200.
May, E.L. Private communication.
Pars, H. G., Granchelli, F. E., Keller, J. K., & Razdan, R. K. Communication to the Editor, Journal of the American Chemical Society, 1966, 18, 3664.
Pars, H.G., & Razdan, R.K. Annals of the New York Academy of Sciences, 1971, 121, 15.
Pars, H.G., Granchelli, F.E., Razdan, R.K., Rosenberg, F., Teiger, D., & Harris, L.S. Journal of Medicinal Chemistry, 1976, in press.
Razdan, R.K., & Pars, H.G. In C.R.B. Joyce & S.H. Curry (Eds.), The Botany and Chemistry of Cannabis. London: J. & H. Churchill, 1970, 137.
Razdan, R.K., Zitko-Terris, B., Pars, H.G., Plotnikoff, N.P., Dodge, P.W., Dren, A.T., Kyncl, J., & Somani, P. Journal of Medicinal Chemistry, 1976, in press (a).
Razdan, R.K., Zitko-Terris, B., Handrick, G.R., Dalzell, H.C., Pars, H.G., Howes, J.F., Plotnikoff, N., Dodge, P., Dren, A.T., Kyncl, J., Shoer, L., & Thompson, W.R. Journal of Medicinal Cnemistry, 1976, in press (b).
Razdan, R. K., Handrick, G.R., Dalzell, H.C., Howes, J.F., Winn, M., Plotnikoff, N., Dodge, P.W., & Dren, A.T. Journal of Medicinal Chemistry, 1976, in press (c).
Sidell, F.R., Pless, J.E., Neitlich, H., Sussman, P., Copeland, W.W., & Sim, V.M. Proceedings of the Society of Experimental Biology and Medicine, 1973, 142, 867.
Villarreal, J.E., Seevers, M.H., & Swain, H.M. Symposium on “Approaches to Centrally Acting Drugs Derived From the Cannabinoid Nucleus.” Presented at the 68th American Chemical Society Meeting, Atlantic City, N. J., 1974 (Abstract).
Zitko, B.A., Dalzell, B.O., Dalzell, H.C., Dewey, W.L., Harris, L.S., Pars, H.G., Razdan, R.K., & Sheehan, J.C. Science, 1972, 177, 442.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Publishing Corporation
About this chapter
Cite this chapter
Pars, H.G., Razdan, R.K. (1976). Heterocyclic Analogs of the Cannabinoids. In: Cohen, S., Stillman, R.C. (eds) The Therapeutic Potential Of Marihuana. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4286-1_31
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4286-1_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4288-5
Online ISBN: 978-1-4613-4286-1
eBook Packages: Springer Book Archive