Abstract
Calculus is a method of reasoning by computation of symbols and in medicine this has traditionally followed the path laid out by the physics of the nineteenth and twentieth century, with its smooth continuous functions and differential equations to make predictions. In the latter part of the twentieth century physical scientists began to look in earnest at complex phenomena and discovered to their surprise that the analytic functions they had touted for so long were not adequate for characterising the variations in any but the simplest of processes. This particular failing was discussed from a statistics perspective in an earlier chapter. It is now time to squarely face the general limitations of the traditional modelling techniques in medicine and address a calculus of medicine that is able to incorporate nonlinearity into its descriptions.
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Notes
- 1.
 z n+1  =  z n 2  +  c, where z n and c are complex numbers, z 0  =  0, and c is a point on the plain. The formula is iterated until |z n | (the magnitude of z) is greater than or equal to the bailout value 2.
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Sturmberg, J.P., West, B.J. (2013). Fractals in Physiology and Medicine. In: Sturmberg, J., Martin, C. (eds) Handbook of Systems and Complexity in Health. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4998-0_11
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