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Regulation of Taurine Release in the Hippocampus of Developing and Adult Mice

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Taurine 8

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 775))

Abstract

Taurine release in mouse hippocampal slices is regulated by several neurotransmitter receptor systems. The ionotropic glutamate receptors and the adenosine receptor A1 are the most effective. The effect of N-methyl-d-aspartate receptors is mediated via activation of the pathway involving nitric oxide and 3′,5′-cyclic guanosine monophosphate. The activation of excitatory amino acid receptors causes at the same time an increase in taurine release. The activation of adenosine A1 receptors also potentiates taurine release. The taurine released may counteract any excitotoxic effects of glutamate, particularly in the developing hippocampus.

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Abbreviations

AMPA:

2-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate

8-Br-cGMP:

8-Bromoguanosine 3′,5′-cyclic monophosphate

CACA:

Cis-4-aminocrotonate

cGMP:

3′,5′-Cyclic guanosine monophosphate

CGS 21680:

2-p-(2-Carboxyethyl)phenylamino-5′-N-ethylcarboxaminoadenosine hydrochloride

CHA:

N 6-Cyclohexyladenosine

CNQX:

6-Cyano-7-nitroquinoxaline-2,3-dione

DPCPX:

8-Cyclopentyl-1,3-dipropylxanthine

DMPX:

3,7-Dimethyl-1-propargylxanthine

GABA:

γ-Aminobutyrate

NBQX:

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo(f)quinoxaline-7-sulfonamide

MK-801:

[5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (dizocilpine)

NMDA:

N-methyl-d-aspartate

NO:

Nitric oxide

R-PIA:

R(−)N 6-(2-Phenylisopropyl)adenosine

TACA:

Trans-4-aminocrotonate

TPMPA:

(1,2,5,6-Tetrahydro-pyridine-4-yl)methylphosphinate

ZAPA:

(Z)-3-[(Aminoiminomethyl)thioprop-2-enoate

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Author information

Authors and Affiliations

  1. Department of Paediatrics, Tampere University Hospital, Tampere, Finland

    Simo S. Oja

  2. Medical School, University of Tampere, FI-33014, Tampere, Finland

    Pirjo Saransaari

Authors
  1. Simo S. Oja
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  2. Pirjo Saransaari
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Corresponding author

Correspondence to Simo S. Oja .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

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Oja, S.S., Saransaari, P. (2013). Regulation of Taurine Release in the Hippocampus of Developing and Adult Mice. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 775. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6130-2_11

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