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Effects of GDNF on Nigrostriatal Dopamine Neurons

Experience from rodent models of Parkinson’s Disease

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The Basal Ganglia VI

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 54))

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Abstract

Glial cell line-derived neurotrophic factor (GDNF) have been found to be a very potent neurotrophic factor for nigrostriatal dopamine neurons in vitro and in vivo. Intracerebral administration of GDNF can produce three principal structural effects. (1) increased survival of lesioned adult DA neurons, (2) sprouting of new fibers dopamine fibers and (3) pharmacological effects related to altered synthesis, turnover and metabolism of dopamine. These effects may in turn promote restoration of function in animals models of Parkinson’s disease. This chapter will summarise the different GDNF induced effects observed and discuss how they may vary depending on which lesion model have been used as well as the treatment regime applied for GDNF.

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Authors and Affiliations

  1. Dept. of Physiological Sciences, Sect. Neurobiology, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    Carl Rosenblad, Deniz Kirik & Anders Björklund

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  1. Carl Rosenblad
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  2. Deniz Kirik
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Editors and Affiliations

  1. Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Ann M. Graybiel

  2. Emory University, Atlanta, Georgia, USA

    Mahlon R. Delong

  3. University of Tennessee Memphis, Memphis, Tennessee, USA

    Stephen T. Kitai

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Rosenblad, C., Kirik, D., Björklund, A. (2002). Effects of GDNF on Nigrostriatal Dopamine Neurons. In: Graybiel, A.M., Delong, M.R., Kitai, S.T. (eds) The Basal Ganglia VI. Advances in Behavioral Biology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0179-4_12

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