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Fundamentals of Freeze-Drying

  • Chapter
Development and Manufacture of Protein Pharmaceuticals

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 14))

Abstract

The development of freeze-dried injectable pharmaceutical products has traditionally been a process of trial and error, both with respect to the composition of the formulation and the process conditions used during freeze-drying. Although this approach ultimately may result in an acceptable product, it is a time-consuming and labor-intensive process, and is unlikely to result in the highest quality product attainable or in a freeze-dry process which is optimized.

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Authors and Affiliations

  1. School of Pharmacy, Purdue University, West Lafayette, Indiana, 47907, USA

    Steven L. Nail

  2. Bayer Corporation, Clayton, North Carolina, 27606, USA

    Shan Jiang

  3. Drug Control Division, Food and Drug Administration, Muang, Nontaburi, 11000, Thailand

    Suchart Chongprasert

  4. Genetics Institute, Andover, Massachusetts, 01810, USA

    Shawn A. Knopp

Authors
  1. Steven L. Nail
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  2. Shan Jiang
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  3. Suchart Chongprasert
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  4. Shawn A. Knopp
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Editor information

Editors and Affiliations

  1. Purdue University, West Lafayette, Indiana, USA

    Steve L. Nail

  2. Baxter Pharmaceutical Solutions LLC, Bloomington, Indiana, USA

    Michael J. Akers

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© 2002 Springer Science+Business Media New York

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Nail, S.L., Jiang, S., Chongprasert, S., Knopp, S.A. (2002). Fundamentals of Freeze-Drying. In: Nail, S.L., Akers, M.J. (eds) Development and Manufacture of Protein Pharmaceuticals. Pharmaceutical Biotechnology, vol 14. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-0549-5_6

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  • DOI: https://doi.org/10.1007/978-1-4615-0549-5_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-5127-6

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