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The Influence of the Intestinal Unstirred Water Layers on the Understanding of the Mechanisms of Lipid Absorption

  • Chapter
Intestinal Lipid Metabolism

Abstract

The accurate measurement of the rates of uptake from the intestinal lumen into the enterocyte is central to the elucidation of the cellular processes associated with intestinal absorption of lipids. From the knowledge of the correct rates of uptake, it is possible to determine the permeability properties of the intestinal brush border membrane (BBM), and therefore its lipophilic properties. The permeability of the BBM is subject to adaptation in health and disease (Thomson and Wild, 1997a, 1997b). For example, the uptake of lipids increases with the feeding of a saturated as compared with a polyunsaturated diet, with aging, and with diabetes mellitus. For the treatment of obesity or hyperlipidemia, it may be desirable to develop therapeutic strategies that will reduce the absorption of lipids. Therefore, it becomes necessary to ensure that the experimentally determined rates of lipid uptake are correct, and that the mechanisms of lipid uptake are correctly understood.

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Authors and Affiliations

  1. Cell and Molecular Biology Collaborative Network in Gastrointestinal Physiology, Nutrition and Metabolism Research Group, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2C2, Canada

    Alan B. R. Thomson

  2. Department of Medicine, Division of Gastroenterology, Department of Anatomy and Cell Biology, McGill University, Montreal, H3A 2T5, Canada

    Gary Wild

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  1. Alan B. R. Thomson
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Editors and Affiliations

  1. University of Tennessee College of Medicine, Memphis, Tennessee

    Charles M. Mansbach II

  2. University of Cincinnati College of Medicine, Cincinnati, Ohio

    Patrick Tso

  3. University of Toronto, Toronto, Ontario, Canada

    Arnis Kuksis

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Thomson, A.B.R., Wild, G. (2001). The Influence of the Intestinal Unstirred Water Layers on the Understanding of the Mechanisms of Lipid Absorption. In: Mansbach, C.M., Tso, P., Kuksis, A. (eds) Intestinal Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1195-3_8

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