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Potential Functions of the Clotting System in Wound Repair

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Injuries of many types and degrees, ranging from inflammation to frank blood vessel disruption, lead to plasma extravasation and extravascular fibrin clot formation. The clot is composed of crosslinked fibrin and fibronectin and platelets that together entrap plasma water, plasma proteins, and blood cells, primarily erythrocytes. This fibrin gel matrix not only halts bleeding but also establishes a provisional matrix for the influx of inflammatory cells and par-enchymal cells into the injured tissue. With time, this surface clot dessicates to form the familiar scab, which in turn sloughs as wound healing proceeds from below.

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Authors and Affiliations

  1. Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Harold F. Dvorak

  2. Division of Allergy, Rheumatology, and Clinical Immunology, Department of Medicine, The State University of New York at Stony Brook, Health Sciences Center, Stony Brook, New York, 11794, USA

    Allen P. Kaplan

  3. Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, 80206, USA

    Richard A. F. Clark

  4. Charles A. Dana Research Institute, Boston, Massachusetts, 02115, USA

    Harold F. Dvorak

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    R. A. F. Clark  & P. M. Henson  & 

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Dvorak, H.F., Kaplan, A.P., Clark, R.A.F. (1998). Potential Functions of the Clotting System in Wound Repair. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_3

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