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Dendritic Cells in Fundamental and Clinical Immunology pp 457–460Cite as

Dendritic Cell-T Cell Conjugates that Migrate from Normal Human Skin are an Explosive Site of Infection for HIV-1

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 378))

Abstract

Distinctive features of dendritic cells include their potent antigen presenting capabilities and their migratory properties. Stimulation of the skin using contact sensitzing agents1,2, or following transplantation3, “activates” dendritic cells to migrate into the afferent lymphatics and on to the draining lymph node. Movement of dendritic cells via the lymph1,4–6 to the lymph node provides an explanation for the dependence on intact, cutaneous afferent lymphatics for effective primary immune responses to contact allergens7 and transplants8 in situ. Furthermore, injection of ex vivo antigen-pulsed dendritic cells back into mice results in migration of the dendritic cells to the draining lymphoid tissue9, where CD4+ T cells are primed10–12.

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Author information

Authors and Affiliations

  1. Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York, 10021, USA

    Melissa Pope, Michiel G. H. Betjes, Stuart Gezelter, Paul U. Cameron & Ralph M. Steinman

  2. Department of Dermatology, University of Innsbruck, 6020, Innsbruck, Austria

    Nickolaus Romani & Gerold Schuler

  3. Division of Plastic Surgery, Cornell University Medical College, New York, New York, 10021, USA

    Haideh Hirmand & Lloyd Hoffman

Authors
  1. Melissa Pope
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  2. Michiel G. H. Betjes
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  3. Nickolaus Romani
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  4. Haideh Hirmand
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  5. Lloyd Hoffman
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  6. Stuart Gezelter
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  7. Gerold Schuler
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  8. Paul U. Cameron
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  9. Ralph M. Steinman
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Editor information

Editors and Affiliations

  1. Laboratory for Immunological Research, Schering-Plough, Dardilly, France

    Jacques Banchereau

  2. INSERM U346, Hôpital Edouard Herriot, Lyon, France

    Daniel Schmitt

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© 1995 Springer Science+Business Media New York

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Pope, M. et al. (1995). Dendritic Cell-T Cell Conjugates that Migrate from Normal Human Skin are an Explosive Site of Infection for HIV-1. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_102

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  • DOI: https://doi.org/10.1007/978-1-4615-1971-3_102

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5811-4

  • Online ISBN: 978-1-4615-1971-3

  • eBook Packages: Springer Book Archive

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