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Recognition of Cell Surface Carbohydrates by C-Type Animal Lectins

  • Chapter
Cellular Adhesion

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

Protein-carbohydrate interactions often mediate recognition events at the cell surface. Examples include cell-cell adhesion, such as the targeting of certain T lymphocytes to their sites of action (Springer and Lasky, 1991), and the binding of sperm to egg (Wassarman, 1987); the clearance of glycoproteins from the circulation (Ashwell and Harford, 1982); host recognition of pathogens (Ezekowitz, 1991); and the binding of certain viruses (Paulson, 1985) and toxins (van Heyningen, 1983) to their target cells. Each of these cases involves the recognition of specific carbohydrate structures. Recent progress in physical and structural characterization has greatly increased our understanding of these interactions at the molecular level.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York, USA, 10032

    William I. Weis

  2. Department of Cell Biology, Stanford University School of Medicine, Stanford, California, USA, 94305

    William I. Weis

Authors
  1. William I. Weis
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Editor information

Editors and Affiliations

  1. SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania, USA

    Brian W. Metcalf , Barbara J. Dalton  & George Poste ,  & 

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Weis, W.I. (1994). Recognition of Cell Surface Carbohydrates by C-Type Animal Lectins. In: Metcalf, B.W., Dalton, B.J., Poste, G., Schatz, J. (eds) Cellular Adhesion. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2466-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2466-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6050-6

  • Online ISBN: 978-1-4615-2466-3

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