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Membrane Proximity and Internal Binding in the Microbial Recognition of Host Cell Glycolipids: A Conceptual Discussion

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Molecular Recognition in Host-Parasite Interactions

Abstract

Carbohydrates are important receptor substances on animal cells for the attachment of various microbes. The distinct development during the last few years of assay, separation and structural techniques for glycoconjugates, in combination with improved information in microbial molecular biology, is at present contributing with information on receptor characteristics that holds promise also for drug design.1 The most spectacular example in the microbial area is the crystal conformation of the complex of influenza virus hemagglutinin with its receptor, N-acetylneuraminic acid or sialic acid,2 allowing considerations at an atomic level.

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Karlsson, KA. et al. (1992). Membrane Proximity and Internal Binding in the Microbial Recognition of Host Cell Glycolipids: A Conceptual Discussion. In: Korhonen, T.K., Hovi, T., Mäkelä, P.H. (eds) Molecular Recognition in Host-Parasite Interactions. Federation of European Microbiological Societies Symposium Series, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3038-1_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3038-1_14

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