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Anti-Idiotypic Regulation of the Alloimmune Response in Patients Transfused with Platelet Concentrates

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Immunology and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 28))

Abstract

Platelet transfusions have increased markedly in recent years with a resulting awareness of problems associated with transfusion therapy. A major problem in patients who receive multiple platelet transfusions has been the development of alloimmunization and a consequent state of clinical refractoriness to random donor platelet transfusions. Patients develop antiplatelet antibodies which shorten the survival of the transfused platelets; anti-HLA antibodies are most common, but platelet-specific antibodies can also occur. The incidence of alloimmunization to HLA in patients with acute leukemia is approximately 30–40% [1–5].

Supported by a grant from the Cutter Biological/Canadian Red Cross Society Research and Development Fund.

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Author information

Authors and Affiliations

  1. Division of Hematology, St. Michael’s Hospital, Toronto, Ontario, Canada

    J. W. Semple, E. Atlas & J. Freedman

  2. Departments of Pharmacology and Medicine, University of Toronto, Canada

    J. W. Semple

  3. Hospital for Sick Children, Toronto, Ontario, Canada

    V. Blanchette

  4. Hôpital Broussais, Paris, France

    M. D. Kazatchkine

Authors
  1. J. W. Semple
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  2. E. Atlas
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  3. J. Freedman
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  4. V. Blanchette
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  5. M. D. Kazatchkine
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. University of Groningen, The Netherlands

    T. H. The (Professor of Clinical Immunology) (Professor of Clinical Immunology)

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© 1993 Springer Science+Business Media Dordrecht

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Semple, J.W., Atlas, E., Freedman, J., Blanchette, V., Kazatchkine, M.D. (1993). Anti-Idiotypic Regulation of the Alloimmune Response in Patients Transfused with Platelet Concentrates. In: Sibinga, C.T.S., Das, P.C., The, T.H. (eds) Immunology and Blood Transfusion. Developments in Hematology and Immunology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3094-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-3094-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6352-1

  • Online ISBN: 978-1-4615-3094-7

  • eBook Packages: Springer Book Archive

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