Abstract
Resting B lymphocytes are small dense cells that express cell surface IgM and IgD. Resting B cells from mouse spleen can be stimulated to proliferate and differentiate to immunoglobulin secretion by the combined action of direct contact with activated helper T (Th) cell clones and lymphokines secreted by Th cells. The mechanism by which this productive interaction of B cells and Th cells is mediated is most likely a multi-step process as outlined in Figure 11. Specific B cells internalize protein antigens, degrade them to peptides and present the peptides on their cell surface in association with class II MHC molecules. This MHC-antigen complex on an antigen presenting B cell is recognized by an antigen-specific Th cell and results in Th cell activation. Surface molecules involved in this interaction are class II MHC, T cell receptor and associated proteins, and adhesion molecules such as LFA-1 and its ligands. Ligation of the T cell receptor complex induces the expression of a set of activation-specific genes that encode secreted lymphokines, proteins that modify existing molecules to potentially modulate their activity, and possibly new cell surface molecules.
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Kehry, M.R., Castle, B.E., Hodgkin, P.D. (1992). B-Cell Activation Mediated by Interactions with Membranes from Helper T Cells. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_18
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DOI: https://doi.org/10.1007/978-1-4615-3396-2_18
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