Abstract
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells represent the two main effector lymphocyte populations thought to be involved in killing virus-infected and transformed cells (reviewed in Berke, 1983; Herberman et al., 1986; Trinchieri and Perussia, 1984; Goldfarb, 1986). Killing by lymphocytes is known to require a contact-dependent mechanism. Although the precise mechanisms by which lymphocytes kill their targets are still unclear, a large body of information has recently accumulated on various mediators that may play a direct role in lymphocyte-mediated killing. This information will be reviewed briefly here.
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Young, J.DE., Liu, CC., Kwon, B.S., Trapani, J.A., Young, L.H.Y. (1991). Lymphocyte-Mediated Cytolysis Role of Granule Mediators. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_6
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