Abstract
The ordered execution of the two main events of cellular reproduction, duplication of the genome and cell division, characterize progression through the cell cycle. Cultured cells can be switched between cycling and non-cycling states by alteration of extracellular conditions and the notion that a critical cellular control mechanism presides on this decision, whose temporal location is known as the restriction point, has become the focus for the study of how extracellular mitogenic signalling impinges upon the cell cycle to influence proliferation. This review attempts to cover the disparate pathways of Ras-mediated mitogenic signal transduction that impact upon restriction point control.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Pardee, A.B. (1974) Proc. Natl. Acad. Sci. USA 71, 1286–1290.
Pardee, A.B., Dubrow, R., Hamlin, J.L. and Kletzien, R.F. (1978) Ann. Rev. Biochem. 47, 715–750.
Pardee, A.B. (1989) Science 246, 603–608.
Zetterberg, A. and Larson, O. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 137–147.
Zetterberg, A., Larsson, O. and Wiman, K.G. (1995) Curr. Opin. Cell Biol. 7, 835–842.
Temin, H. (1971) J. Cell. Physiol. 78, 161–170.
Rossow, P.W., Riddle, V.G.H. and Pardee, A.B. (1979) Proc. Natl. Acad. Sci. USA 76, 4446–4450.
Brooks, R.F. (1977) Cell 12, 311–317.
Zetterberg, A. and Larsson, O. (1985) Proc. Natl. Acad. Sci. USA 82, 5365–5369.
Rous, P. (1911) J. Exp. Med. 13, 397–411.
Temin, H.M. (1964) Natl. Cancer Inst. Monogr. 17, 557–570.
Temin, H.M. and Mizutani, S. (1970) Nature 226, 1211–1213.
Baltimore, D. (1970) Nature 226, 1209–1211.
Stehelin, D., Guntaka, R.V., Varmus, H.E. and Bishop, J.M. (1976) J. Mol. Biol. 101, 349–365.
Stehelin, D., Varmus, H.E., Bishop, J.M. and Vogt, P.K. (1976) Nature 260, 170–173.
Ellis, R.W., DeFeo, D., Maryak, J.M., Young, H.A., Shih, T.Y., Chang, E.H., Lowy, D.R. and Scolnick, E.M. (1980) J. Virol. 36, 408–420.
Harvey, J.J. (1964) Nature 204, 1104–1105.
Kirsten, W.H. (1967) J. Natl. Cancer Inst. 39, 311–335.
Ellis, R.W., Defeo, D., Shih, T.Y., Gonda, M.A., Young, H.A., Tsuchida, N., Lowy, D.R. and Scolnick, E.M. (1981) Nature 292, 506–511.
Shih, C., Padhy, L.C., Murray, M. and Weinberg, R.A. (1981) Nature 290, 261–264.
Krontiris, T.G. and Cooper, G.M. (1981) Proc. Natl. Acad. Sci. USA 78, 1181–1184.
Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. and Wigler, M. (1981) Cell 27, 467–476.
Avery, O.T., MacLeod, C.M. and McCarty, M. (1944) J. Exp. Med. 79, 137–158.
Parada, L.F., Taabin, C.J., Shih, C. and Weinberg, R.A. (1982) Nature 297, 474–478.
Der, C.J., Krontiris, T.G. and Cooper, G.M. (1982) Proc. Natl. Acad. Sci. USA 79, 3637–3640.
Goldfarb, M., Shimizu, K., Prucho, M. and Wigler, M. (1982) Nature 296, 404.
Tabin, C.J., Bradley, S.M., Bargmann, C.I. and Weinberg, R.A. (1982) Nature 300, 143–149.
Reddy, E.P., Reynolds, R.K., Santos, E. and Barbacid, M. (1982) Nature 300, 149–152.
Taparowsky, E., Suard, Y., Fasano, O., Shimuzu, K., Goldfarb, M. and Wigler, M. (1982) Nature 300, 762–765.
Bos, J.L. (1989) Cancer Res. 49, 4682–4689.
Scolnick, E.M., Papageorge, A.G. and Shih, T.Y. (1979) Proc. Natl. Acad. Sci. USA 76, 5355–5359.
Shih, T.Y., Papageorge, A.G., Stokes, P.E., Weeks, M.O. and Scolnick, E.M. (1980) Nature 287, 686–691.
Temeles, G.L., Gibbs, J.B., D’Alonzo, J.S., Sigal, I.S. and Scolnick, E.M. (1985) Nature 313, 700–703.
Willingham, M.C., Pastan, I., Shih, T.Y. and Scolnick, E.M. (1980) Cell 19, 1005–1014.
Willumsen, B.M., Christensen, A., Hubbert, N.L., Papageorge, A.G. and Lowy, D.R. (1984) Nature 310, 583–586.
Sefton, B.M., Trowbridge, I.S., Cooper, J.A. and Scolnick, E.M. (1982) Cell 31, 465–474.
Downward, J., Graves, J.D., Warne, P.H., Rayter, S. and Cantrell, D.A. (1990) Nature 346, 719–723.
Scher, C.D., Stone, M.E. and Stiles, C.D. (1979) Nature 281, 390–392.
Feramisco, J.R., Gross, M., Kamata, T., Rosenberg, M. and Sweet, R.W. (1984) Cell 38, 109–117.
Stacey, D.W. and Kung, H.F. (1984) Nature 310, 508–511.
Mulcahy, L.S., Smith, M.R. and Stacey, D.W. (1985) Nature 313, 241–243.
Dobrowolski, S., Harter, M. and Stacey, D.W. (1994) Mol. Cell. Biol. 14, 5441–5449.
Feig, L.A. and Cooper, G.M. (1988) Mol. Cell. Biol. 8, 3235–3243.
Okuda, K., Ernst, T.J. and Griffin, J.D. (1994) J. Biol. Chem. 269, 24602–24607.
Winston, J.T., Coats, S.R., Wang, Y.Z. and Pledger, W.J. (1996) Oncogene 12, 127–134.
Valius, M. and Kazlauskas, A. (1993) Cell 73, 321–334.
Egan, S.E., Giddings, B.W., Brooks, M.W., Buday, L., Sizeland, A.M. and Weinberg, R.A. (1993) Nature 363, 45–51.
Li, N., Batzer, A., Daly, R., Yajnik, V., Skolnik, E., Chardin, P., Bar-Sagi, D., Margolis, B. and Schlessinger, J. (1993) Nature 363, 85–88.
Gale, N.W., Kaplan, S., Lowenstein, E.J., Schlessinger, J. and Bar-Sagi, D. (1993) Nature 363, 88–92.
Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T. and Bowtell, D. (1993) Nature 363, 83–85.
Oliver, J.P., Raabe, T., Henkemeyer, M., Dickson, B., Mbamalu, G., Margolis, B., Schlessinger, J., Hafen, E. and Pawson, T. (1993) Cell 73, 179–191.
Buday, L. and Downward, J. (1993) Cell 73, 611–620.
Chardin, P., Camonis, J.H., Gale, N.W., Van Aelst, L., Schlessinger, J., Wigler, M.H. and Bar-Sagi, D. (1993) Science 260, 1338–1343.
Aronheim, A., Engelberg, D., Li, N., Al-Alawi, N., Schlessinger, J. and Karin, M. (1994) Cell 78, 949–961.
Taylor, S.J. and Shalloway, D. (1996) Curr. Biol. 6, 1621–1627.
Moodie, S.A., Willumsen, B.M., Weber, M.J. and Wolfman, A. (1993) Science 260, 1658–1661.
Vojtek, A.B., Hollenberg, S.M. and Cooper, J.A. (1993) Cell 74, 205–214.
Dent, P., Haser, W., Haystead, T.A.J., Vincent, L.A., Roberts, T.M. and Sturgill, T.W. (1992) Science 257, 1404–1407.
Howe, L.R., Leevers, S.J., Gomez, N., Nakielny, S., Cohen, P. and Marshall, C. (1992) Cell 71, 335–342.
Kyriakis, J., App, H., Zhang, X., Banerjee, P., Brautigan, D., Rapp, U. and Avruch, J. (1992) Nature 358, 417–421.
Marshall, C.J. (1994) Curr. Opin. Genet. and Devel. 4, 82–89.
Hill, C.S. and Treisman, R. (1995) Cell 80, 199–211.
Cooper, J.A., Bowen-Pope, D.F., Raines, E., Ross, R. and Hunter, T. (1982) Cell 31, 263–273.
Nakamura, K.D., Martinez, R. and Weber, M.J. (1983) Mol. Cell. Biol. 3, 380–390.
Cooper, J.A., Sefton, B.M. and Hunter, T. (1984) Mol. Cell. Biol. 4, 30–37.
Kohno, M. (1985) J. Biol. Chem. 260, 1771–1779.
Kolch, W., Heidecker, G., Lloyd, P. and Rapp, U.R. (1991) Nature 12, 426–428.
Samuals, M.L. and McMahon, M. (1994) Mol. Cell. Biol. 14, 7855–7866.
Cowley, S., Paterson, H., Kemp, P. and Marshall, C.J. (1994) Cell 77, 841–852.
Brunet, A., Pages, G. and Pouysségur, J. (1994) Oncogene 9, 3379–3387.
Pages, G., Lenorman, P., L’Allemain, G., Chambard, J.-C., Meloche, S. and Pouysségur, J. (1993) Proc. Natl. Acad. Sci. USA 90, 8319–8323.
Meloche, S., Seuwen, K., Pages, G. and Pouysségur, J. (1992) Mol. Endocrinol. 6, 845–854.
Tamemoto, H., Kadowaki, T., Tobe, K., Ueki, K., Izumi, T., Chatan, Y., Kohno, M., Kasuga, M., Yazaki, Y. and Akanuma, Y. (1992) J. Biol. Chem. 267, 20293–20297.
Bennett, A.M., Hausdorff, S.F., O’Reilly, A.M., Freeman, R.M. and Neel, B.G. (1996) Mol. Cell. Biol. 16, 1189–1202.
Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M.D. and Downward, J. (1994) Nature 370, 527–532.
Roche, S., Koegl, M. and Courtneidge, S.A. (1994) Proc. Natl. Acad. Sci. LISA 91, 9185–9189.
Hu, Q., Kippel, A., Muslin, A.J., Fantl, W.J. and Williams, L.T. (1995) Science 268, 100–102.
Lane, H.A., Fernandez, A., Lamb, N.J.C. and Thomas, G. (1993) Nature 363, 170–172.
Reinhard, C., Fernandez, A., Lamb, N.J.C. and Thomas, G. (1994) EMBO J. 13, 1557–1565.
Chung, J., Grammer, T.C., Lemon, K.P., Kazlauskas, A. and Blenis, J. (1994) Nature 370, 71–74.
Burgering, B.M.T. and Coffer, P.J. (1995) Nature 376, 599–602.
Ming, X.-F., Burgering, B.M.T., Wennstrom, S., Claesson-Welsh, L., Heldin, C.-H., Bos, J.L., Kozma, S.C. and Thomas, G. (1994) Nature 371, 426–429.
Downward, J. (1998) Curr. Opin in Genet. Dev. 8, 49–54.
Chou, M.M. and Blenis, J. (1996) Cell 85, 573–583.
Wennstrom, S., Siegbahn, A., Yokote, K., Arvidsson, A.-K., Heldin, C.-H., Mori, S. and Claesson-Welsh, L. (1994) Oncogene 9, 651–660.
Nobes, C.D., Hawkins, P., Stephens, L. and Hall, A. (1995) J. Cell Science 108, 225–223.
Carpenter, C.L. and Cantley, L.C. (1996) Biochim. Biophys. Acta 1288, M11–M16.
Olson, M.F., Ashworth, A. and Hall, A. (1995) Science 269, 1270–1272.
Qiu, R.-G., Abo, A., McCormick, F. and Symons, M. (1997) Mol. Cell. Biol. 17, 3449–3458.
Qiu, R.-G., Chen, J., Kirn, D., McCormick, F. and Symons, M. (1995) Nature 374, 457–459.
Qiu, R.-G., Chen, J., McCormick, F. and Symons, M. (1995) Proc. Natl. Acad. Sci. USA 92, 11781–11785.
Khosravi-Far, R., Soski, P.A., Clark, G.J., Kinch, M.S. and Der, C.J. (1995) Mol. Cell. Biol. 15, 6443–6453.
Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. and Hall, A. (1992) Cell 70, 401–410.
Julien-Flores, V., Dorseuil, O., Romero, F., Letourneur, F., Saragosti, S., Berger, R., Tavitian, A., Gacon, G. and Camonis, J.H. (1995) J. Biol. Chem. 270, 22473–22477.
Settleman, J., Albright, C.F., Foster, L.C. and Weinberg, R.A. (1992) Nature359, 153–154.
Nobes, C. and Hall, A. (1994) Curr. Opin. Genet. Dev. 4, 77–81.
Nimnual, A.S., Yatsula, B.A. and Bar-Sagi, D. (1998) Science 279, 560–563.
Westwick, J.K., Lambert, Q.T., Clark, G.J., Symons, M., Van Aelst, L., Pestell, R.G. and Der, C.J. (1997) Mol. Cell. Biol. 17, 1324–1335.
Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M. (1995) Cell 81, 1147–1157.
Coso, O.A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Mild, T. and Gutkind, J.S. (1995) Cell 81, 1137–1146.
Alberts, A.S., Geneste, O. and Treisman, R. (1998) Cell 92, 475–487.
White, M.A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M.H. (1995) Cell 80, 533–541.
Joneson, T., White, M.A., Wigler, M.H. and Bar-Sagi, D. (1996) Science 271, 810–812.
Rodriguez-Viciana, P., Warne, P.H., Khwaja, A., Marte, B.M., Pappin, D., Ridley, A. and Downward, J. (1997) Cell 89, 457–467.
Mitchison, J.M. (1971) The Biology of the Cell Cycle. Cambridge University Press, Cambridge
Proud, C.G. (1994) Nature 371, 747–748.
Lin, T.-A., Kong, X., Haystead, T.A., Pause, A., Belsham, G., Sonenberg, N. and Lawrence, J.J.C. (1994) Science 266, 653–656.
Pause, A., Belsham, G.J., Gingras, A.-C., Donze, O., Lin, T.-A., Lawrence, J.J.C. and Sonenberg, N. (1994) Nature 371, 762–767
Lohka, M.J., Hayes, M.K. and Mailer, J.L. (1988) Proc. Natl. Acad. Sci. USA 85, 3009–3013.
Gautier, J., Norbury, C., Lohka, M., Nurse, P. and Mailer, J. (1988) Cell 54, 433–439.
Dunphy, W.G., Brizuela, L., Beach, D. and Newport, J. (1988) Cell 54, 423–431.
Nurse, P. (1975) Nature 256, 547–551.
Nurse, P. and Thuriaux, P. (1980) Genetics 96, 627–637.
Draetta, G., Brizuela, L., Potashkin, J. and Beach, D. (1987) Cell 50, 319–325.
Arion, D., Meijer, L., Brizuela, L. and Beach, D. (1988) Cell 55, 371–378.
Evans, T., Rosenthal, E.T., Youngblom, J., Distel, D. and Hunt, T. (1983) Cell 33, 389–396.
Swenson, K.I., Farrell, K.M. and Ruderman, J.V. (1986) Cell 47, 861–870.
Pines, J. and Hunt, T. (1987) EMBO J. 6, 2987–2995.
Solomon, M., Booher, R., Kirschner, M. and Beach, D. (1988) Cell 54, 738–739.
Pines, J. and Hunter, T. (1989) Cell 58, 833–846.
Pines, J. and Hunter, T. (1990) Nature 346, 760–763.
Nurse, P. and Bissett, Y. (1981) Nature 292, 558–560.
Blow, J.J. and Nurse, P. (1990) Cell 62, 855–862.
Gabrielli, B.G., Roy, L.M., Gautier, J., Philippe, M. and Maller, J.L. (1992) J. Biol. Chem. 267, 1969–1975.
Fang, F. and Newport, J.W. (1991) Cell 66, 731–742.
Elledge, S.J., Richman, R., Hall, F.L., Williams, R.T., Lodgson, N. and Harper, J.W. (1992) Proc. Natl. Acad. Sci. USA 89, 2907–2911.
Ninomiya-Tsuji, J., Nomoto, S., Yasuda, H., Reed, S.I. and Matsumoto, K. (1991) Proc. Natl. Acad. Sci. USA 88, 9006–9010.
Tsai, L.H., Harlow, E. and Meyerson, M. (1991) Nature 353, 174–177.
Tsai, L., Lees, E., Faha, B., Harlow, E. and Riabowol, K. (1993) Oncogene 8, 1593–1602.
van den Heuvel, S. and Harlow, E. (1993) Science 262, 2050–2054.
Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M. and Roberts, J.M. (1991) Cell 66, 1217–1228.
Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S., Nishimoto, T., Morgan, D.O., Franza, B.R. and Roberts, J.M. (1992) Science 257, 1689–1694.
Lew, D.J., Dulic, V. and Reed, S.I. (1991) Cell 66,1197–1206.s
Dulic, V., Lees, E. and Reed, S.I. (1992) Science 257, 1958–1961.
Matsushime, H., Roussel, M.F., Ashmun, R.A. and Sherr, C.J. (1991) Cell 65, 701–713.
Xiong, Y., Connolly, T., Futcher, B. and Beach, D. (1991) Cell 65, 691–699.
Motokura, T., Bloom, T., Kim, H.G., Juppner, H., Ruderman, J.V., Kronenberg, H.M. and Arnold, A. (1991) Nature 350, 512–515.
Matsushime, H., Ewen, M.E., Strom, D.K., Kato, J.-Y., Hanks, S.K., Roussel, M.F. and Sherr, C.J. (1992) Cell 71, 323–334.
Meyerson, M. and Harlow, E. (1994) Mol. Cell. Biol. 14, 2077–2086.
Quelle, D.E., Ashmun, R.A., Shurtleff, S.A., Kato, J., Bar-Sagi, D., Roussel, M.F. and Sherr, C.J. (1993) Genes Dev. 7, 1559–1571.
Ohtsubo, M. and Roberts, J.M. (1993) Science 259, 1908–1912.
Morgan, D.O. (1995) Nature 374, 131–134.
Sherr, C.J. and Roberts, J.M. (1995) Genes Dev. 9, 1149–1163.
Dyson, N. (1998) Genes Dev. 12, 2245–2262.
Weinberg, R.A. (1995) Cell 81, 323–330.
Sherr, C.J. (1994) Cell 79, 551–555.
Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.I. and Weinberg, R.A. (1992) Cell 70, 993–1006.
Ewen, M.E., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J.-Y. and Livingston, D.M. (1993) Cell 73, 487–497.
Dowdy, S.F., Hinds, P.W., Louie, K., Reed, S.I., Arnold, A. and Weinberg, R.A. (1993) Cell 73, 499–511.
Kato, J.-Y., Matsushime, H., Hiebert, S.W., Ewen, M.E. and Sherr, C.J. (1993) Genes Dev. 7, 331–342.
Lundberg, A.S. and Weinberg, R.A. (1998) Mol. Cell. Biol. 18, 753–761.
Baldin, V., Lukas, J., Marcote, M.J., Pagano, M. and Draetta, G. (1993) Genes Dev. 7, 812–821.
Lukas, J., Muller, H., Bartkova, J., Spitkovsky, D., Kjerulff, A.A., Jansen-Durr, P., Strauss, M. and Bartek, J. (1994) J. Cell Biol. 125, 625–638.
Lukas, J., Bartkova, J., Rohde, M., Strauss, M. and Bartek, J. (1995) Mol. Cell. Biol. 15, 2600–2611.
Medema, R.H., Herrera, R.E., Lam, F. and Weinberg, R.A. (1995) Proc. Natl. Acad. Sci. USA 92, 6289–6293.
Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Barkova, J., Strauss, M., Peters, G. and Bartek, J. (1995) Nature 375, 503–506.
Koh, J., Enders, G.H., Dynlacht, B.D. and Harlow, E. (1995) Nature 375, 506–510.
Guan, K.-L., Jenkins, C.W., Li, Y., Nickols, M.A., Wu, X., O’Keefe, C.L., Matera, A.G. and Xiong, Y. (1994) Genes Dev. 8, 2939–2952.
Serrano, M., Gomez-Lohoz, E., DePinho, R.A., Beach, D. and Bar-Sagi, D. (1995) Science 267, 249–252.
Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M. and Pagano, M. (1995) Mol. Cell. Biol. 15, 2612–2624.
Resnitzky, D. and Reed, S.I. (1995) Mol. Cell. Biol. 15, 3463–3469.
Clurman, B.E., Sheaff, R.J., Thress, K., Groudine, M. and Roberts, J.M. (1996) Genes Dev. 10, 1979–1990.
Sheaff, R.J., Groudine, M., Gordon, M., Roberts, J.M. and Clurman, B.E. (1997) Genes Dev. 11, 1464–1478.
Zhao, J., Dynlacht, B., Imai, T., Hori, T.-a. and Harlow, E. (1998) Genes Dev. 12, 456–461.
Krude, T., Jackman, M., Pines, J. and Lasky, R.A. (1997) Cell 88, 109–119.
Sewing, A., Burger, C., Brusselback, S., Schalk, C., Lucibello, F.C. and Muller, R. (1993) J. Cell. Sci. 104, 545–555.
Won, K.-A., Xiong, Y., Beach, D. and Gilman, M.Z. (1992) Proc. Natl. Acad. Sci. USA 89, 9910–9914.
Winston, J.T. and Pledger, W.J. (1993) Mol. Biol. Cell 4, 133–1144.
Liu, J.-J., Chao, J.-R., Jiang, M.-C., Ng, S.-Y., Yen, J.J.-Y. and Yang-Yen, H.F. (1995) Mol. Cell. Biol. 15, 3654–3663.
Lavoie, J.N., L’Allemain, G., Brunet, A., Muller, R. and Pouysségur, J. (1996) J. Biol. Chem. 271, 20608–20616.
Filmus, J., Robles, A.I., Shi, W., Wong, M.J., Colombo, L.L. and Conti, C.J. (1994) Oncogene 9, 3627–3633.
Vogt, P.K. and Bos, T.J. (1990) Adv. Cancer Res. 55, 2–36.
Kovary, K. and Bravo, R. (1991) Mol. Cell. Biol. 11, 4466–4472.
Carter, R., Yumet, G., Pena, A., Soprano, D.R. and Soprano, K.J. (1994) Oncogene 9, 2675–2682.
Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A. and Pestell, R.G. (1995) J. Biol. Chem. 270, 23589–23597.
Herber, B., Truss, M., Beato, M. and Muller, R. (1994) Oncogene 9, 1295–1304.
Brown, J.R., Nigh, E., Lee, R.J., Ye, H., Thompson, M.A., Saudou, F., Pestell, R.G. and Greenberg, M.E. (1998) Mol. Cell. Biol. 18, 5609–5619.
Nourse, J., Firpo, E., Flanagan, W.M., Coats, S., Polyak, K., Lee, M.H., Massagué, J., Crabtree, G.R. and Roberts, J.M. (1994) Nature 372, 570–573.
Firpo, E.J., Koff, A., Solomon, M.J. and Roberts, J.M. (1994) Mol. Cell. Biol. 14, 4889–4901.
Li, Y., Jenkins, C.W., Nichols, M.A. and Xiong, Y. (1994) Oncogene 9, 2261–2268.
Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Exp. Cell Res. 211, 90–98.
Hengst, L., Dulic, V., Slingerland, J.M., Lees, E. and Reed, S.I. (1994) Proc. Natl. Acad. Sci. USA 91, 5291–5295.
Kato, J.-y., Matsuoka, M., Polyak, K., Massagué, J. and Sherr, C.J. (1994) Cell 79, 487–496.
Aprelikova, O., Xiong, Y. and Liu, E.T. (1995) J. Biol. Chem.270, 18195–18197.
Koff, A., Ohtsuki, M., Polyak, K., Roberts, J.M. and Massagué, J. (1993) Science 260, 536–539.
Polyak, K., Kato, J.-Y., Solomon, M.J., Sherr, C.J., Massagué, J., Roberts, J.M. and Koff, A. (1994) Genes Dev. 8, 9–22.
Li, R., Waga, S., Hannon, G.J., Beach, D. and Stillman, B. (1994) Nature 371, 534–537.
Zhang, H., Hannon, G.J. and Beach, D. (1994) Genes Dev. 8, 1750–1758.
Soos, T.J., Kiyokawa, H., Yan, J.S., Rubin, M.S., Giordano, A., DeBlasio, A., Bottega, S., Wong, B., Mendelsohn, J. and Koff, A. (1996) Cell Growth Diff. 7, 135–146.
LaBaer, J., Garrett, M.D., Stevenson, L.F., Slingerland, J.M., Sandhu, C., Chou, H.S., Fattaey, A. and Harlow, E. (1997) Genes Dev. 11, 847–862.
Sewing, A., Wiseman, B., Lloyd, A. and Land, H. (1997) Mol. Cell. Biol. 17, 5588–5597.
Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees, E. and McMahon, M. (1997) Mol. Cell. Biol. 17, 5598–5611.
Kerkhoff, E. and Rapp, U.R. (1997) Mol. Cell. Biol. 17, 2576–2586.
Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J. and Kato, J.-Y. (1994) Mol. Cell. Biol. 14, 2066–2076.
Ladha, M.H., Lee, K.Y., Upton, T.M., Reed, M.F. and Ewen, M.E. (1998) Mol. Cell. Biol. 18, 6605–6615.
Cheng, M., Sexl, V., Sherr, C.J. and Roussel, M.F. (1998) Proc. Natl. Acad. Sci. USA 95, 1091–1096.
Olson, M.F., Paterson, H.F. and Marshall, C.J. (1998) Nature 394, 295–299.
Coats, S., Flanagan, W.M., Nourse, M. and Roberts, J.M. (1996) Science 272, 877–880.
Rivard, N., L’Allemain, G., Bartek, J. and Pouysségur, J. (1996) J. Biol. Chem. 271, 18337–18341.
Winston, J., Dong, F. and Pledger, W.J. (1996) J. Biol. Chem. 271, 11253–11260.
Aktas, H., Cai, H. and Cooper, G.M. (1997) Mol. Cell. Biol. 17, 3850–3857.
Takuwa, N. and Takuwa, Y. (1997) Mol. Cell. Biol. 17, 5348–5358.
Weber, J.D., Hu, W., Jefcoat, S.C.J., Raben, D.M. and Baldassare, J.J. (1997) J. Biol. Chem. 272, 32966–32971.
Herrera, R.E., Sah, V.P., Williams, B.O., Makela, T.P., Weinberg, R.A. and Jacks, T. (1996) Mol. Cell. Biol. 16, 2402–2407.
Peeper, D.S., Upton, T.M., Ladha, M.H., Neuman, E., Zalvide, J., Bernards, R., DeCaprio, J.A. and Ewen, M.E. (1997) Nature 386, 177–181.
Mittnacht, S., Paterson, H., Olson, M.F. and Marshall, C.J. (1997) Curr. Biol. 7, 219–221.
Leone, G., DeGregori, J., Sears, R., Jakoi, L. and Nevins, J.R. (1997) Nature 387, 422–426.
Ewen, M.E. (1998) inCell Cycle Control(Pagano, M., ed.) pp. 149–179, Springer, New York, NY.
Smith, E.J., Leone, G., DeGregori, J., Jakoi, L. and Nevins, J.R. (1996) Mol. Cell. Biol. 16, 6965–6976.
Newbold, R.F. and Overell, R.W. (1983) Nature 304, 648–651.
Land, H., Parada, L.F. and Weinberg, R.A. (1983) Nature 304, 596–602.
Ruley, H.E. (1983) Nature 304, 602–606.
Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D. and DePinho, R.A. (1996) Cell 85, 27–37.
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. and Lowe, S.W. (1997) Cell 88, 593–602.
Levine, A.J. (1997) Cell 88, 323–331.
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M.S., Aizawa, S., Mak, T.W. and Taniguchi, T. (1994) Cell77, 829–839.
Hayflick, L. and Moorhead, P.S. (1961) Exptl. Cell Res. 25, 585–621.
Chin, L., Pomerantz, J., Polsky, D., Jacobson, M., Cohen, C., Cardon-Cardo, C., Horner, I.J.W. and DePinho, R.A. (1997) Genes Dey. 11, 2822–2834.
Quelle, D.E., Zindy, F., Ashmun, R.A. and Sherr, C.J. (1995) Cell 83, 993–1000.
Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G. and Sherr, C.J. (1997) Cell 91, 649–659.
Pomerantz, J., Schreiber-Agus, N., Liegeois, N.J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., Cordon-Cardo, C. and DePinho, R.A. (1998) Cell 92, 713–723.
Zhang, Y., Xiong, Y. and Yarbrough, W.G. (1998) Cell 92, 725–734.
Johnson, L., Greenbaum, D., Cichowski, K., Mercer, K., Murphy, E., Schmitt, E., Bronson, R.T., Umanoff, H., Windfried, E., Kucherlapati, R. and Jacks, T. (1997) Genes Dey. 11, 2468–2481.
Umanoff, H., Edelmann, W., Pellicer, A. and Kucherlapati, R. (1995) Proc. Natl. Acad. Sci. USA 92, 170
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ewen, M.E. (2000). Relationship between Ras pathways and cell cycle control. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_1
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4253-7_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6909-7
Online ISBN: 978-1-4615-4253-7
eBook Packages: Springer Book Archive