Abstract
One of the highest national priorities that has been established for biomedical science in the United States is the control of cancer. Whether that control be achieved through prevention or through treatment, it will probably necessitate a better understanding of the etiology, pathogenesis, and pathophysiology of cancer than is current. In the process of investigation we should also be aware of man’s mortality and the possibility that cancer is an intricate part of that larger, uncontrollable problem. To the extent that cancer is caused by spontaneous, time-dependent changes, such as may accumulate from somatic mutation, prevention is a cruel dream; to the extent that cancer is accelerated by controllable environmental agents, prevention is a realistic hope. Clearly, we need to have a firm understanding of the etiology of cancer and of the interaction of genetic and environmental factors involved therein.
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References
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Knudson, A.G. (1977). Genetics and Etiology of Human Cancer. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics 8. Advances in Human Genetics, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8267-0_1
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