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The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

  • Chapter
Chemical Mutagens

Abstract

Mutagenesis and carcinogenesis are complex cellular processes which are grossly similar in that each produces heritable changes in phenotype. Experimental mutagenesis by a pure chemical agent was first achieved by Auerbach and Robson (1944, 1946) and a variety of such agents are now known. Their mechanisms of action appear to be fairly well understood as consisting of expressible heritable changes in the molecular structure of the genetic material or DNA (Orgel, 1965; Freese and Freese, 1966; Auerbach, 1967; Freese, this book). Carcinogenesis by chemical agents was discovered first in humans almost 200 years ago, and today nearly a dozen agents active in the human and of widely varying structure are known (Clayson, 1962; Hueper and Conway, 1964; Miller, J. A., 1970). The experimental induction of cancer with a pure chemical compound was first achieved about 1930, and many chemical carcinogens of greatly differing structures are known today (see preceding references). However, it is not known at the molecular level how any chemical carcinogen induces the formation of cells which are not responsive to the growth controls of the host and which form neoplasms that grow more or less continuously and may invade normal tissues. This is also true of the carcinogenic action of viruses and radiation. Likewise, the molecular phenotype of no neoplasm is even partially understood.

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References

  • Abell, C. W., Falk, H. L., Shimkin, M. B., Weisburger, E. K., Weisburger, J. H., and Gubareff, N. (1965), Science 147, 1443.

    PubMed  CAS  Google Scholar 

  • Alderson, T., and Clark, A. M. (1966), Nature 210, 593.

    PubMed  CAS  Google Scholar 

  • Andersen, R. A., Enomoto, M., Miller, E. C., and Miller, J. A. (1964), Cancer Res. 24, 128.

    PubMed  CAS  Google Scholar 

  • Auerbach, C. (1939–40), Proc. Roy. Soc. Edinburgh, Ser. B. 60, 164 (quoted by Burdette, W. J. (1955), Cancer Res. 15, 201).

    Google Scholar 

  • Auerbach, C. (1967), Science 158, 1141.

    PubMed  CAS  Google Scholar 

  • Auerbach, C., and Robson, J. M. (1944), Nature 154, 81.

    CAS  Google Scholar 

  • Auerbach, C., and Robson, J. M. (1946), Nature 157, 302.

    PubMed  CAS  Google Scholar 

  • Bauer, K. H. (1928), “Mutationstheorie der Geschwulst-Enstehung. Übergang von Körperzellen in Geschwulstzellen durch Gen-Änderung, ” Springer-Verlag, Berlin.

    Google Scholar 

  • Bauer, K. H. (1963) “Das Krebsproblem, ” Springer-Verlag, Berlin.

    Google Scholar 

  • Baldwin, R. W., and Smith, W. R. D. (1965), Brit. J. Cancer 19, 433.

    PubMed  CAS  Google Scholar 

  • Barratt, R. W., and Tatum, E. L. (1951), Cancer Res. 11, 234.

    Google Scholar 

  • Barratt, R. W., and Tatum, E. L. (1958), Ann. N.Y. Acad. Sci. 71, 1072.

    PubMed  CAS  Google Scholar 

  • Bateman, A. J. (1967), Mutation Res. 4, 710.

    PubMed  CAS  Google Scholar 

  • Belman, S., Troll, W., Teebor, G., and Mukai, F. (1968), Cancer Res. 28, 535.

    PubMed  CAS  Google Scholar 

  • Bhattacharya, S. A. (1949), Proc. Zool. Soc. Bengal 2, 187 (quoted by Burdette, W. J. (1955), Cancer Res. 15, 201).

    Google Scholar 

  • Boutwell, R. K., Colburn, N. H., and Muckerman, C. C. (1969), Ann. N.Y. Acad. Sci. 163, 751.

    CAS  Google Scholar 

  • Boveri, T. (1929), “The Origin of Malignant Tumors” (first published Jena, 1914), Williams and Wilkins Co., Baltimore.

    Google Scholar 

  • Boyland, E. (1964), Brit. Med. Bull. 20, 121.

    PubMed  CAS  Google Scholar 

  • Boyland, E. (1969), in “The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Vol. I. Physico-Chemical Mechanisms of Carcinogenesis” (E. D. Bergmann and B. Pullman, eds.) p. 25, Israel Academy of Sciences and Humanities, Jerusalem.

    Google Scholar 

  • Boyland, E., and Nery, R. (1965), Biochem. J. 94, 198.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1962), Biochem. J. 84, 571.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1964), Biochem. J. 91, 493.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1965a), Biochem. J. 95, 780.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1965b), Biochem. J. 95, 788.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1965c), Biochem. J. 97, 7.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Sims, P. (1967), Internat. J. Cancer 2, 500.

    CAS  Google Scholar 

  • Boyland, E., and Williams, K. (1969), Biochem. J. 111, 121.

    PubMed  CAS  Google Scholar 

  • Boyland, E., Dukes, C. E., and Grover, P. L. (1963), Brit. J. Cancer 18, 575.

    Google Scholar 

  • Boyland, E., Busby, E. R., Dukes, C. E., Grover, P. L., and Manson, D. (1964), Brit. J. Cancer 19, 575.

    Google Scholar 

  • Boyland, E., Sims, P., and Huggins, C. (1965), Nature 207, 816.

    PubMed  CAS  Google Scholar 

  • Brink, N. G. (1966), Mutation Res. 3, 66.

    PubMed  CAS  Google Scholar 

  • Brink, N. G. (1969), Mutation Res. 8, 139.

    PubMed  CAS  Google Scholar 

  • Brookes, P., and Dipple, A. (1967), “British Empire Cancer Campaign 45th Annual Report, ” Part II, p. 20.

    Google Scholar 

  • Brookes, P., and Dipple, A. (1969), in “The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Vol. I. Physico-Chemical Mechansisms of Carcinogenesis” (E. D. Bergmann and B. Pullman, eds.) p. 139, Israel Academy of Sciences and Humanities, Jerusalem.

    Google Scholar 

  • Brookes, P., and Lawley, P. D. (1960), Biochem. J. 77, 478.

    PubMed  CAS  Google Scholar 

  • Brookes, P., and Lawley, P. D. (1964), J. Cell. Comp. Physiol. 64 (Suppl. 1), 111.

    CAS  Google Scholar 

  • Brown, G. B., Sugiura, K., and Cresswell, R. M. (1965), Cancer Res. 25, 986.

    PubMed  CAS  Google Scholar 

  • Bryan, G. T., Brown, R. R., and Price, J. M. (1964), Cancer Res. 24, 596.

    PubMed  CAS  Google Scholar 

  • Büch, H., Rummel, W., Pfleger, K., Eschrich, C., and Texter, N. (1968), Naunyn-Schmiedebergs Arch. Pharm. Exp. Pathol. 259, 276.

    Google Scholar 

  • Bull, L. B., Culvenor, C. C. J., and Dick, A. T. (1968), “The Pyrrolizidine Alkaloids, ” North Holland Publishing Co., Amsterdam.

    Google Scholar 

  • Burdette, W. J. (1952), Cancer Res. 12, 201.

    PubMed  CAS  Google Scholar 

  • Burdette, W. J. (1955), Cancer Res. 15, 201.

    PubMed  CAS  Google Scholar 

  • Burdette, W. J., and Haddox, C. H., Jr. (1954), Cancer Res. 14, 163.

    PubMed  CAS  Google Scholar 

  • Butler, T. C. (1961), J. Pharmacol. Exp. Therap. 134, 311.

    CAS  Google Scholar 

  • Cessi, C., Colombini, C., and Mameli, L. (1966), Biochem. J. 101, 46c.

    Google Scholar 

  • Chu, E. H. Y., Bailiff, E. E., and Mailing, H. V. (1970), “Abstracts Tenth International Cancer Congress, ” p. 62, Houston.

    Google Scholar 

  • Clark, A. M. (1960), Z. Vererb. 91, 74.

    CAS  Google Scholar 

  • Clark, A. M. (1963), Z. Vererb. 94, 115.

    CAS  Google Scholar 

  • Clayson, D. B. (1962), “Chemical Carcinogenesis, ” Little, Brown Co., Boston.

    Google Scholar 

  • Cleaver, J. E. (1969), Radiation Res. 37, 334.

    PubMed  CAS  Google Scholar 

  • Colburn, N. H., and Boutwell, R. K. (1968a), Cancer Res. 28, 642.

    PubMed  CAS  Google Scholar 

  • Colburn, N. H., and Boutwell, R. K. (1968b), Cancer Res. 28, 653.

    PubMed  CAS  Google Scholar 

  • Corbett, T. H., Dove, W. F., and Heidelberger, C. (1970), Mol. Pharmacol., in press.

    Google Scholar 

  • Costa, A., Weber, G., and St. Omer, F. B. (1963), Arch. de Vecchi Anat. Path. 39, 357.

    Google Scholar 

  • Cramer, J. W., Miller, J. A., and Miller, E. C. (1960), J. Biol. Chem. 235, 250.

    PubMed  CAS  Google Scholar 

  • Culvenor, C. C. J., Dann, A. T., and Dick, A. T. (1962), Nature 195, 570.

    PubMed  CAS  Google Scholar 

  • Culvenor, C. C. J., Downing, D. T., Edgard, J. A., and Jago, M. V. (1969), Ann. Ann. N.Y. Acad. Sci. 163, 837.

    CAS  Google Scholar 

  • DeBaun, J. R., Miller, E. C., and Miller, J. A. (1970a), Cancer Res., 30, 577.

    PubMed  CAS  Google Scholar 

  • DeBaun, J. R., Smith, J. Y. R., Miller, E. C., and Miller, J. A. (1970b), Science 167, 184.

    PubMed  CAS  Google Scholar 

  • Della Porta, G., Terracini, B., and Shubik, P. (1961), J. Nat. Cancer Inst. 26, 855.

    Google Scholar 

  • Demerec, M. (1948), “Proceedings of the Eighth International Congress on Genetics, ” p. 201, Hereditas Supplement.

    Google Scholar 

  • Demerec, M., and Hanson, J. (1951), Cold Spring Harbor Symp. Quant. Biol. 16, 215.

    PubMed  CAS  Google Scholar 

  • Demerec, M., Wallace, B., Witkin, E. M., and Bertani, G. (1949), Carnegie Inst. Wash. Year Book 48, 156.

    Google Scholar 

  • Demerec, M., Bertani, G., and Flint, J. (1951), Am. Nat. 85, 119.

    CAS  Google Scholar 

  • Dipple, A., and Slade, T. A. Europ. J. Cancer (in press).

    Google Scholar 

  • Druckrey, H., Steinhoff, D., Beuthner, H., Schneider, H., and Klämer, P. (1963), Arzneimittel-Forsch. 13, 320.

    CAS  Google Scholar 

  • Druckrey, H., Preussmann, R., Ivankovic, S., Schmähl, D., Afkham, Blum, G., Mennel, H. D., Muller, M., Petropoulos, P., and Schneider, H. (1967), Z. Krebsforsch. 69, 103.

    PubMed  CAS  Google Scholar 

  • Druckrey, H., Kruse, H., and Preussmann, R. (1968), Naturwissenschaften 55, 449.

    PubMed  CAS  Google Scholar 

  • Druckrey, H., Preussmann, R., and Ivankovic, S. (1969), Ann. N.Y. Acad. Sci. 163, 676.

    CAS  Google Scholar 

  • Endo, H. (1958), Gann, 49, 151.

    CAS  Google Scholar 

  • Endo, H., and Kume, F. (1965), Gann 56, 261.

    PubMed  CAS  Google Scholar 

  • Endo, H., Wada, A., Miura, K. I., Hidaka, Z., and Hiruki, C. (1961), Nature 190, 833.

    CAS  Google Scholar 

  • Enomoto, M., Sato, K., Miller, E. C., and Miller, J. A. (1968), Life Sci. 7, 1025.

    PubMed  CAS  Google Scholar 

  • Epstein, S. S. (1970), in “Environmental Chemical Mutagens—Principles and Methods for Their Detection” (A. Hollander, ed.) Plenum Press, New York.

    Google Scholar 

  • Epstein, S. S., and St. Pierre, J. A. (1969), Toxicol. Appl. Pharmacol. 15, 451.

    PubMed  CAS  Google Scholar 

  • Epstein, S. S., and Shafner, H. (1968) Nature 219, 385.

    PubMed  CAS  Google Scholar 

  • Fahmy, O. G., and Fahmy, M. J. (1969), Nature 224, 1328.

    PubMed  CAS  Google Scholar 

  • Fahmy, O. G., and Fahmy, M. J. (1970), Cancer Res. 30, 195.

    PubMed  CAS  Google Scholar 

  • Farber, E. (1963), Adv. Cancer Res. 7, 383.

    PubMed  CAS  Google Scholar 

  • Farber, E., McConomy, J., Franzen, B., Marroquin, F., Stewart, G. A.., and Magee., P. N. (1967), Cancer Res. 27, 1761.

    PubMed  CAS  Google Scholar 

  • Fowler, J. S. L. (1969), Brit. J. Pharmacol. 36, 181P.

    Google Scholar 

  • Freese, E. (1963), in “Molecular Genetics” (J. H. Taylor, ed.) Part I, Chapter V, Academic Press, New York.

    Google Scholar 

  • Freese, E. (1970), in “Environmental Chemical Mutagens—Principles and Methods for Their Detection” (A. Hollander, ed.) Plenum Press, New York.

    Google Scholar 

  • Freese, E., and Freese, E. B. (1966), Radiation Res. 6 (Suppl.), 97.

    Google Scholar 

  • Freese, E., and Strack, H. B. (1962). Proc. Nat. Acad. Sci., 48, 1796.

    PubMed  CAS  Google Scholar 

  • Freese, E., Bautz, F., and Freese, E. B. (1961), Proc. Nat. Acad. Sci. 47, 845.

    PubMed  CAS  Google Scholar 

  • Fried, J., and Schumm, D. E. (1967), J. Am. Chem. Soc. 89, 5508.

    PubMed  CAS  Google Scholar 

  • Gabridge, M. G., and Legator, M. S. (1969), Proc. Soc. Exp. Biol. Med. 130, 831.

    PubMed  CAS  Google Scholar 

  • Gelboin, H. V. (1967), Adv. Cancer Res. 10, 1.

    PubMed  CAS  Google Scholar 

  • Gelboin, H. V. (1969), Cancer Res. 29, 1272.

    PubMed  CAS  Google Scholar 

  • Giovanni-Donnelly, R. de, Kolbye, S. M., and DiPaolo, J. A. (1967), Mutation Res. 4, 543.

    PubMed  Google Scholar 

  • Goldschmidt, B. M., Blazej, T. P., and Van Duuren, B. L. (1968), Tetrahedron Letters, p. 1583.

    Google Scholar 

  • Goodall, C. M., and Butler, W. H. (1969), Internat. J. Cancer 4, 422.

    CAS  Google Scholar 

  • Grasso, P., and Golberg, L. (1966), Food Cosmet. Toxicol. 4, 297.

    PubMed  CAS  Google Scholar 

  • Grover, P. L., and Sims, P. (1969), Biochem. J. 110, 159.

    Google Scholar 

  • Grover, P. L., and Sims, P. (1970), Biochem. Pharmacol. 19, 2251.

    PubMed  CAS  Google Scholar 

  • Haddow, A., and Horning, E. S. (1960), J. Nat. Cancer Inst. 24, 109.

    PubMed  CAS  Google Scholar 

  • Hartwell, J. L. (1951), “Survey of Compounds Which Have Been Tested for Carcinogenic Activity, ” U.S. Public Health Service Publication No. 149.

    Google Scholar 

  • Heidelberger, C. (1964), J. Cell. Comp. Physiol. 64 (Suppl. 1), 129.

    Google Scholar 

  • Hueper, W. C., and Conway, W. D. (1964), “Chemical Carcinogenesis and Cancers, ” Charles C Thomas, Springfield, Ill.

    Google Scholar 

  • Iijima, T., and Hagiwara, A. (1960), Nature 185, 395.

    PubMed  CAS  Google Scholar 

  • Ikegami, R., Akamatsu, Y., and Haruta, M (1967), Acta Pathol. Japan 17, 495.

    CAS  Google Scholar 

  • Innes, J. R. M., Ulland, B. M., Valerno, M. G., Petrucelli, L., Fishbein, L., Hart, E. R., Pallotta, A. J., Bates, R. R., Falk, H. L., Gart, J. J., Klein, M., Mitchell, I., and Peters, J. (1969), J. Nat. Cancer Inst. 42, 1101.

    PubMed  CAS  Google Scholar 

  • Irving, C. C. (1962), Cancer Res. 22, 867.

    CAS  Google Scholar 

  • Irving, C. C. (1965), J. Biol. Chem. 240, 1011.

    PubMed  CAS  Google Scholar 

  • Irving, C. C., and Russell, L. T. (1970), Biochemistry 9, 2471.

    PubMed  CAS  Google Scholar 

  • Irving, C. C., and Veazey, R. A. (1969), Cancer Res. 29, 1799.

    PubMed  CAS  Google Scholar 

  • Irving, C. C., Gutmann, H. R., and Larson, D. M. (1963), Cancer Res. 23, 1782.

    PubMed  CAS  Google Scholar 

  • Irving, C. C., Wiseman, R., Jr., and Hill, J. T. (1967), Cancer Res. 27, 2309.

    PubMed  CAS  Google Scholar 

  • Irving, C. C., Veazey, R. A., and Hill, J. T. (1969a), Blochim. Biophys. Acta 179, 189.

    CAS  Google Scholar 

  • Irving, C. C., Veaszey, R. A., and Russell, L. T. (1969b), Chemico-Biol. Interactions 1, 19.

    CAS  Google Scholar 

  • Jensen, K. A., Kirk, I., Kolmark, G., and Westergaard, M. (1951), Cold Spring Harbor Symp. Quant. Biol. 16, 245.

    PubMed  CAS  Google Scholar 

  • Juhasz, J. (1967), in “Potential Carcinogenic Hazards from Drugs” (R. Truhaut, ed.), U.I.C.C. Monograph, Vol. 7, p. 180 Springer-Verlag, Berlin.

    Google Scholar 

  • Kimball, R. F. (1968), Photochem. Photobiol. 8, 515.

    PubMed  CAS  Google Scholar 

  • Koller, P. C. (1969), Mutation Res. 8, 199.

    PubMed  CAS  Google Scholar 

  • Krieg, D. R. (1963), Prog. Nucleic Acid Res. 2, 125.

    Google Scholar 

  • Kriek, E. (1968), Biochim. Biophys. Acta 161, 273.

    PubMed  CAS  Google Scholar 

  • Kriek, E. (1969), Chemico-Biol. Interactions 1, 3.

    CAS  Google Scholar 

  • Kriek, E., Miller, J. A., Juhl, U., and Miller, E. C. (1967), Biochemistry 6, 117.

    Google Scholar 

  • Krüger, F. W., Preussmann, R., and Niepelt, N. (1970), “Abstracts, Tenth International Cancer Congress, ” p. 4, Houston.

    Google Scholar 

  • Laqueur, G. L., and Matsumoto, H. (1966), J. Nat. Cancer Inst. 37, 217.

    PubMed  CAS  Google Scholar 

  • Laqueur, G. L., and Spatz, M. (1968), Cancer Res. 28, 2262.

    PubMed  CAS  Google Scholar 

  • Laqueur, G. L., McDaniel, E. G., and Matsumoto, H. (1967), J. Nat. Cancer Inst. 39, 355.

    PubMed  CAS  Google Scholar 

  • Latarjet, R., Buu-Hoi, N. P., and Elias, C. A. (1950), Publ. Staz. Zool. Napoli 22, 78 (quoted by Burdette, W. J. (1955), Cancer Res. 15, 201).

    CAS  Google Scholar 

  • Lawley, P. D. (1966), Prog. Nucleic Acid Res. 5, 89.

    CAS  Google Scholar 

  • Lawley, P. D., and Brookes, P. (1963), Biochem. J. 89, 127.

    PubMed  CAS  Google Scholar 

  • Lawley, P. D., and Thatcher, C. J. (1970), Biochem. J. 116, 693.

    PubMed  CAS  Google Scholar 

  • Lee, K. Y., and Goodall, C. M. (1968), Biochem. J. 106, 767.

    PubMed  CAS  Google Scholar 

  • Legator, M., and Epstein, S. S. (in press), in “Non-psychiatric Hazards of Drugs of Abuse” (S. S. Epstein and J. Lederberg, eds.) National Institutes of Mental Health, U.S. Government Printing Office.

    Google Scholar 

  • Legator, M. S., and Mailing, H. V. (1971), in “Chemical Mutagens—Principles and Methods for Their Detection (A. Hollaender, ed.) Plenum Press, New York.

    Google Scholar 

  • Lerman, L. S. (1965), J. Cell. Comp. Physiol. 64 (Suppl. 1), 1.

    Google Scholar 

  • Lijinsky, W., and Ross, A. E. (1969), J. Nat. Cancer Inst. 42, 1095.

    PubMed  CAS  Google Scholar 

  • Lin, J.-K., Miller, J. A., and Miller, E. C. (1968), Biochemistry 7, 1889.

    PubMed  CAS  Google Scholar 

  • Lin, J.-K., Miller, J. A., and Miller, E. C. (1969), Biochemistry 8, 1573.

    PubMed  CAS  Google Scholar 

  • Lotlikar, P. D., Scribner, J. D., Miller, J. A., and Miller, E. C. (1966), Life Sci. 5, 1263.

    CAS  Google Scholar 

  • Loveless, A. (1969), Nature 223, 206.

    PubMed  CAS  Google Scholar 

  • Magee, P. N., and Barnes, J. M. (1967), Adv. Cancer Res. 10, 163.

    PubMed  CAS  Google Scholar 

  • Magee, P. N., and Schoental, R. (1964), Brit. Med. Bull. 20, 102.

    PubMed  CAS  Google Scholar 

  • Maher, V. M., and Summers, W. C. (1970), Nature 225, 68.

    PubMed  CAS  Google Scholar 

  • Maher, V. M., Miller, E. C., Miller, J. A., and Szybalski, W. (1968), Mol. Pharmacol. 4, 411.

    PubMed  CAS  Google Scholar 

  • Maher, V. M., Miller, E. C., Miller, J. A., and Summers, W. C. (1970), Cancer Res., 30, 1473.

    PubMed  CAS  Google Scholar 

  • Maisin, J. H., Lambert, G., and Van Duyse, E. (1953), Acta Unio Internat. Contra Cancrum 9, 693.

    CAS  Google Scholar 

  • Malling, H. V. (1966), Mutation Res. 3, 537.

    CAS  Google Scholar 

  • Malling, H. V., and Cosgrove, G. E., “Proc. Symposium: Chemische Mutagenese bei Sauger und Mensch. Test Systeme und Ergebnisse, ” Mainz, Germany (October 5–8, 1969) (in press).

    Google Scholar 

  • Malling, H. V., and de Serres, F. J. (1969), Ann. N.Y. Acad. Sci. 163, 788.

    CAS  Google Scholar 

  • Matsumoto, H., and Higa, H. H. (1966), Biochem. J. 98, 20C.

    Google Scholar 

  • Matsushima, T., Kobuna, I., and Sugimura, T. (1967), Nature 216, 508.

    PubMed  CAS  Google Scholar 

  • Matsushima, T., Kobuna, I., Fukuoka, F., and Sugimura, T. (1968), Gann 59, 247.

    PubMed  CAS  Google Scholar 

  • Mattocks, A. R. (1968), Nature 217, 723.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., and Miller, J. A. (1966), Pharmacol. Rev. 18, 805.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., and Miller, J. A. (1967), Proc. Soc. Exp. Biol. Med. 124, 915.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Sandin, R. B., Miller, J. A., and Rusch, H. P. (1956), Cancer Res. 16, 525.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Miller, J. A., and Hartmann, H. A. (1961), Cancer Res. 21, 815.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Miller, J. A., and Enomoto, M. (1964), Cancer Res. 24, 2018.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Juhl, U., and Miller, J. A. (1966a), Science 153, 1125.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Lotlikar, P. D., Pitot, H. C., Fletcher, T. L., and Miller, J. A. (1966b), Cancer Res. 26, 2239.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Lotlikar, P. D., Miller, J. A. Butler, B. W., Irving, C. C., and Hill, J. T. (1968), Mol. Pharmacol. 4, 147.

    PubMed  CAS  Google Scholar 

  • Miller, E. C., Smith, J. Y., and Miller, J. A. (1970), Proc. Am. Assoc. Cancer Res. 11, 56.

    Google Scholar 

  • Miller, J. A. (1970), Cancer Res., 30, 559.

    PubMed  CAS  Google Scholar 

  • Miller, J. A., and Miller, E. C. (1953), Adv. Cancer Res. 1, 339.

    PubMed  CAS  Google Scholar 

  • Miller, J. A., and Miller, E. C. (1969a), Prog. Exp. Tumor Res. 11, 273.

    PubMed  CAS  Google Scholar 

  • Miller, J. A., and Miller, E. C. (1969b), in “The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Vol. I. Physico-Chemical Mechanisms of Carcinogenesis” (E. D. Bergman and B. Pullman, eds.) p. 237, The Israel Academy of Sciences and Humanities, Jerusalem.

    Google Scholar 

  • Miller, J. A., Sandin, R. B., Miller, E. C., and Rusch, H. P. (1955), Cancer Res. 15, 188.

    PubMed  CAS  Google Scholar 

  • Miller, J. A., Wyatt, C. S., Miller, E. C., and Hartmann, H. A. (1961), Cancer Res. 21, 1465.

    CAS  Google Scholar 

  • Miller, J. A., Lin, J.-K., and Miller, E. C. (1970), Proc. Am. Assoc. Cancer Res. 11, 56.

    Google Scholar 

  • Mirvish, S. S. (1968), Adv. Cancer Res. 11, 1.

    PubMed  CAS  Google Scholar 

  • Morreal, C. E., Dao, T. L., Eskins, K., King, C. L., and Dienstag, J. (1969), Biochim. Biophys. Acta 169, 224.

    Google Scholar 

  • Mukai, F., and Troll, W. (1969), Ann. N.Y. Acad. Sci. 163, 828.

    CAS  Google Scholar 

  • Munn, A. (1967), in “Bladder Cancer, A Symposium” (W. B. Deichmann, K. F. Lampe, R. A. Penalver, A. Soto, and J. L. Radomski, eds.) p. 187, Aesculapius Publishing Co., Birmingham, Ala.

    Google Scholar 

  • Nagai, S. (1969), Mutation Res. 7, 333.

    PubMed  CAS  Google Scholar 

  • Nagata, Y., and Matsumoto, H. (1969), Proc. Soc. Exp. Biol. Med. 132, 383.

    PubMed  CAS  Google Scholar 

  • Nakahara, W., Fukuoka, F., and Sugimura, T. (1957), Gann 48, 129.

    CAS  Google Scholar 

  • Nery, R. (1969), J. Chem. Soc., p. 1860.

    Google Scholar 

  • Orenstein, J. M., and Marsh, W. H. (1968), Biochem. J. 109, 697.

    PubMed  CAS  Google Scholar 

  • Orgel, L. E. (1965), Adv. Enzymol. 27, 289.

    PubMed  Google Scholar 

  • Ortwerth, B. J., and Novelli, G. D. (1969), Cancer Res. 29, 380.

    PubMed  CAS  Google Scholar 

  • Perez, G., and Radomski, J. L. (1965), Ind. Med. Surg. 34, 714.

    PubMed  CAS  Google Scholar 

  • Pitot, H. C., and Heidelberger, C. (1963), Cancer Res. 23, 1694.

    PubMed  CAS  Google Scholar 

  • Poirier, L. A. (1965), Ph.D. thesis, University of Wisconsim, Madison, Wis.

    Google Scholar 

  • Poirier, L. A., Miller, J. A., Miller, E. C., and Sato, K. (1967), Cancer Res. 27, 1600.

    PubMed  CAS  Google Scholar 

  • Preussman, R., Druckrey, H., and Bücheler, J. (1968), Z. Krebsforsch. 71, 63.

    Google Scholar 

  • Preussman, R., Druckrey, H., Ivankovic, S., and Von Hodenberg, A. (1969a), Ann. N.Y. Acad. Sci. 163, 697.

    Google Scholar 

  • Preussman, R., Von Hodenberg, A., and Hengy, H. (1969b), Biochem. Pharmacol. 18, 1.

    Google Scholar 

  • Price, C. C., Gaucher, G. M., Koneru, P., Shibakawa, R., Sowa, J. R., and Yamaguchi, M. (1968), Biochim. Biophys. Acta 166, 327.

    PubMed  CAS  Google Scholar 

  • Rao, K. S., and Recknagel, R. O. (1969), Exp. Mol. Pathol. 10, 219.

    PubMed  CAS  Google Scholar 

  • Reuber, M. D., and Glover, E. L. (1970), J. Nat. Cancer Inst. 44, 419.

    PubMed  CAS  Google Scholar 

  • Reynolds, E. S. (1967), J. Pharmacol. Exp. Therap. 155, 117.

    CAS  Google Scholar 

  • Roe, F. J. C. (1957), Cancer Res. 17, 64.

    PubMed  CAS  Google Scholar 

  • Rosen, L. (1968), Biochem. Biophys. Res. Commun. 33, 546.

    PubMed  CAS  Google Scholar 

  • Ross, W. C. J. (1962), “Biological Alkylating Agents, ” Butterworth and Co., London.

    Google Scholar 

  • Sacharov, V. V. (1938), Biol. Zh. 7, 595 (quoted by Burdette, W. J. (1955), Cancer Res. 15, 201).

    Google Scholar 

  • Salaman, M. H., and Roe, F. J. C. (1956), Brit. J. Cancer 10, 363.

    PubMed  CAS  Google Scholar 

  • Scherr, G. H., Fishman, M., and Weaver, R. H. (1954), Genetics 39, 141.

    PubMed  CAS  Google Scholar 

  • Schoental, R. (1963), Bull. World Health Org. 29, 823.

    PubMed  CAS  Google Scholar 

  • Schoental, R. (1968a), Cancer Res. 28, 2237.

    PubMed  CAS  Google Scholar 

  • Schoental, R. (1968b), Israel J. Med. Sci. 4, 1133. Scribner, J. D., Miller, E. C., and Miller, J. A., Unpublished data.

    PubMed  CAS  Google Scholar 

  • Scribner, J. D., Miller, J. A., and Miller, E. C. (1965), Biochem. Biophys. Res. Commun. 20, 560.

    PubMed  CAS  Google Scholar 

  • Scribner, J. D., Miller, J. A., and Miller, E. C. (1970), Cancer Res., 30, 1570.

    PubMed  CAS  Google Scholar 

  • Shapiro, R. (1968), Prog. Nucleic Acid Res. Mol. Biol. 8, 73.

    PubMed  CAS  Google Scholar 

  • Shapiro, R. (1969), Ann. N.Y. Acad. Sci. 163, 624.

    CAS  Google Scholar 

  • Shirasu, Y. (1965), Proc. Soc. Exp. Biol. Med. 118, 812.

    PubMed  CAS  Google Scholar 

  • Singer, B., and Fraenkel-Conrat, H. (1969), Prog. Nucleic Acid Res. Mol. Biol. 9, 1.

    PubMed  CAS  Google Scholar 

  • Smith, D. W. E. (1966), Science 152, 1273.

    PubMed  CAS  Google Scholar 

  • Smith, R. H. (1969), Mutation Res. 7, 231.

    PubMed  CAS  Google Scholar 

  • Spatz, M. (1968), Proc. Soc. Exp. Biol. Med. 128, 1005.

    CAS  Google Scholar 

  • Spatz, M. (1969), Ann. N.Y. Acad. Sci. 163, 848.

    CAS  Google Scholar 

  • Stekol, J. A. (1963), Adv. Enzymol. 25, 369.

    PubMed  Google Scholar 

  • Stekol, J. A. (1965), in “Transmethylation and Methionine Biosynthesis” (S. K. Shapiro and F. Schlenk, eds.) p. 231, University of Chicago Press, Chicago. Stöhrer, G., and Brown, G. B. (1970), Science 167, 1622.

    PubMed  Google Scholar 

  • Stöhrer, G., Corbin, E., and Brown, G. B. (1970), Proc. Am. Assoc. Cancer Res. 11, 76.

    Google Scholar 

  • Strong, L. C. (1945), Proc. Nat. Acad. Sci. 31, 290.

    PubMed  CAS  Google Scholar 

  • Strong, L. C. (1952), Cancer Res. 12, 300.

    Google Scholar 

  • Sugimura, T., Okabe, K., and Endo, H. (1965), Gann 56, 489.

    PubMed  CAS  Google Scholar 

  • Sugiura, K., Teller, M. N., Parham, J. C., and Brown, G. B. (1970), Cancer Res. 30, 184.

    PubMed  CAS  Google Scholar 

  • Swann, P. F., and Magee, P. N. (1968), Biochem. J. 110, 39.

    PubMed  CAS  Google Scholar 

  • Swann, P. F., and Magee, P. N. (1969), Nature 223, 947.

    PubMed  CAS  Google Scholar 

  • Szybalski, W., and Iyer, V. N. (1967), in “Antibiotics” (D. Gottlieb and P. D. Shaw, eds.) Vol. I, p. 211, Springer-Verlag, Berlin.

    Google Scholar 

  • Szybalski, W., Bovre, K., Fiandt, M., Guha, A., Hradecna, Z., Kumar, S., Lozeron, H. A., Maher, V. M., Nijkamp, H. J. J., Summers, W. C., and Taylor, K. (1969), J. Cell. Physiol 74 (Suppl. 1), 33.

    PubMed  CAS  Google Scholar 

  • Tada, M., Tada, M., and Takahashi, T. (1967), Biochem. Biophys. Res. Commun. 29, 469.

    PubMed  CAS  Google Scholar 

  • Trainin, N., Kaye, A. M., and Berenblum, I. (1964), Biochem. Pharmacol. 13, 263.

    PubMed  CAS  Google Scholar 

  • Ts’o, P. O. P., Lesko, S. A., and Umans, R. S. (1969), in “The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Vol. I. Physico-Chemical Mechanisms of Carcinogenesis” (E. D. Bergman and B. Pullman, eds.) p. 106, Israel Academy of Sciences and Humanities, Jerusalem.

    Google Scholar 

  • Udenfriend, S., Clark, C. T., Axelrod, J., and Brodie, B. B. (1954), J. Biol. Chem. 208, 731.

    PubMed  CAS  Google Scholar 

  • Van Duuren (1969), Ann. N.Y. Acad. Sci. 163, 633.

    Google Scholar 

  • Van Duuren, B. L., and Sivak, A. (1968), Cancer Res. 28, 2349.

    PubMed  Google Scholar 

  • Van Duuren, B. L., Langseth, L., Goldschmidt, B. M., and Orris, L. (1967), J. Nat. Cancer Inst. 39, 1217.

    PubMed  Google Scholar 

  • Van Duuren, B. L., Sivak, A., Katz, C., and Melchionne, S. (1969), Brit. J. Cancer 23, 587.

    PubMed  Google Scholar 

  • Vogt, M. (1948), Experientia 4, 68.

    PubMed  CAS  Google Scholar 

  • Weinstein, I. B. (1969), in “Genetic Concepts and Neoplasia, Twenty-third Annual Symposium on Fundamental Cancer Research, ” p. 380, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Weisburger, E. K., and Weisburger, J. H. (1958), Adv. Cancer Res. 5, 331.

    PubMed  CAS  Google Scholar 

  • Weisburger, J. H., Yamamoto, R. S., Grantham, P. H., and Weisburger, E. K. (1970), Proc. Am. Assoc. Cancer Res. 11, 82.

    Google Scholar 

  • Wilk, M., and Girke (1969), in “The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Vol. I. Physico-Chemical Mechanisms of Carcinogenesis” (E. D. Bergmann and B. Pullman, eds.) p. 91, Israel Academy of Sciences and Humanities, Israel.

    Google Scholar 

  • Wilk, M., and Hoppe, U. (1970), Liebigs Ann. Chem. 727, 81.

    Google Scholar 

  • Wogan, G. N. (1966), Bacteriol. Rev. 30, 460.

    PubMed  CAS  Google Scholar 

  • Wölcke, U., Birdsall, N. J. M., and Brown, G. B. (1969), Tetrahedron Letters 10, 785.

    Google Scholar 

  • Wolff, S., and Scott, D. (1969), Exp. Cell Res. 55, 9.

    PubMed  CAS  Google Scholar 

  • Yamamoto, R. S., Glass, R. M., Fankel, H. H., Weisburger, E. K., and Weisburger, J. H. (1968), Toxicol. Appl. Pharmacol. 13, 108.

    CAS  Google Scholar 

  • Zimmerman, F. K. (1969a), Z. Krebsforsch. 72, 65.

    Google Scholar 

  • Zimmerman, F. K. (1969b), Arzneimittel-Forsch. 7, 1046.

    Google Scholar 

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  1. McArdle Laboratory for Cancer Research, University of Wisconsin Medical Center, Madison, Wisconsin, USA

    Elizabeth C. Miller & James A. Miller

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  1. Division of Biology, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Alexander Hollaender

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Miller, E.C., Miller, J.A. (1971). The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations. In: Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8966-2_3

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