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The Concept of Drug-Carriers in the Treatment of Parasitic Diseases

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Function and Structure of the Immune System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 114))

Abstract

In many parasitic diseases, the reticulo-endothelial system is the major site of infection. Linking antiparasitic drugs to macro-molecular carriers may therefore extensively improve their therapeutical properties. The drug-carrier complex is no longer able to diffuse through the cell plasma membranes, and will be taken up preferentially by the cells which display high endocytic capacity. Complexed drugs will also be excreted at lower rate than free drugs, leading to increased plasma levels, for prolonged periods. Not the least, cells with low or no endocytic activity will be protected from adverse action of the drug, thus improving the overall therapeutic index of the complex with regard to the free drug.

Chargé de Recherches of the Belgian F.N.R.S.

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References

  1. Trouet, A., Jadin, J.M., Van Hoof, F. In: Biochemistry of parasites and host-parasite relationships. (H. Van den Bossche, ed.) Elsevier/North Holland Biomedical Press, Amsterdam, p. 519. (1977).

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Author information

Authors and Affiliations

  1. Laboratoire de Chimie Physiologique, Université Catholique de Louvain and International Institute of Cellular and Molecular Pathology, avenue Hippocrate, 75, B-1200, Bruxelles, Belgium

    P. Tulkens & A. Trouet

Authors
  1. P. Tulkens
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  2. A. Trouet
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Editor information

Editors and Affiliations

  1. University of Kiel, Kiel, Germany

    Wolfgang Müller-Ruchholtz  & Hans Konrad Müller-Hermelink  & 

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© 1979 Plenum Press, New York

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Tulkens, P., Trouet, A. (1979). The Concept of Drug-Carriers in the Treatment of Parasitic Diseases. In: Müller-Ruchholtz, W., Müller-Hermelink, H.K. (eds) Function and Structure of the Immune System. Advances in Experimental Medicine and Biology, vol 114. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9101-6_66

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  • DOI: https://doi.org/10.1007/978-1-4615-9101-6_66

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9103-0

  • Online ISBN: 978-1-4615-9101-6

  • eBook Packages: Springer Book Archive

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