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Proteases in Hormone Production and Metabolism

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Proteases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 167))

Abstract

The physiologic effect of a hormone is governed by its bioavailability to receptors on the target organ. Chertow (1) has suggested that proteases can potentially regulate hormone availability by 1) intracellular conversion of precursor hormones to active hormones, 2) degradation of hormone in the cell prior to secretion, 3) facilitation of release of hormone from the cell, 4) activation or inactivation of the hormone in the circulation, and 5) degradation of hormone in target tissue. These regulatory mechanisms particularly apply to polypeptide hormones and enzymes, which are produced as larger molecular weight precursors and subsequently converted by limited proteolysis to their secreted forms.

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Authors and Affiliations

  1. Section of Endocrinology, Department of Medicine, LAC/USC Medical Center, Los Angeles, California, 90033, USA

    Willa A. Hsueh

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  1. Willa A. Hsueh
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Editors and Affiliations

  1. University of Würzburg, Würzburg, Federal Republic of Germany

    Walter H. Hörl  & August Heidland  & 

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© 1984 Plenum Press, New York

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Hsueh, W.A. (1984). Proteases in Hormone Production and Metabolism. In: Hörl, W.H., Heidland, A. (eds) Proteases. Advances in Experimental Medicine and Biology, vol 167. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9355-3_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9355-3_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9357-7

  • Online ISBN: 978-1-4615-9355-3

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