Abstract
Since the first reports of the antiviral activity of methisoprinol1,2,3 at least ten clinical trials have evaluated both its clinical efficacy and its lack of toxicity.4 There is also increasing interest in the immunomodulating activity of this drug.5–9 We report herein the results obtained in subjects affected by viral infections or diseases of probable viral etiology with a high frequency of recurrence and the effects of long-term treatment with methisoprinol.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E.R. Brown and P. Gordon, Inosine-alkylamino-alcohol complexes: anti-viral actions, Fed. Proc. 29: 684 (1970).
P. Gordon and E.R., The antiviral activity of isoprinosine, Can. J. Microb. 18: 1463 (1972).
T.W. Chang and L. Weinstein, Antiviral activity of Isoprinosine in vitro and in vivo, Amer. J. Med. Sci. 265 (2): 143 (1973).
A.J. Glasky, J. Kestelyn, and M. Romero, Isoprinosine: a clinical overview of an antiviral-immunomodulating agent, Abstract of 7th International Congress of Pharmacology ( IUPHAR ), Paris, July 1978.
J.W. Hadden, C. Lopez, R.J. O’Reilly, and E.M. Hadden, Levamisole and inosiplex: Antiviral agents with immunopotentiating action, Ann. N.Y. Acad. Sci. 284: 153 (1977).
L.J. Bradshaw and H.L. Sumner, In vitro studies on cell-mediated immunity in patients treated with inosiplex for herpes virus infections, Ann. N.Y. Acad. Sci. 284: 190 (1977)
J.W. Hadden, E.M. Hadden, and R.G. Goffey, Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation, Infect. Immun. 13: 382 (1976).
J. Wybran, A. Govaerts, and T. Appelboom, Inosiplex a stimulating agent for normal human T cells and human leukocytes, J. Immunol. 121: 1184 (1978).
A. Morin, C. Griscelli, and F. Daguillard, Effects de l’Isoprinosine sur l’activation des lymphocites humains in vitro, Ann. Immunol. (Inst. Pasteur) 130 c, 541 (1979).
F. Caredda, F. Capsoni, A. Lazzarin, and M. Moroni, Studio dell effetto in vitro dell-Isoprinosina su alcuni aspetti della funzionalita granulocitaria: risultati preliminari, Atti de Convegno Internazionale sulla Isoprinosina, Roma 28 aprile 1979, pg. 81–83.
F. Aiuti, J.C. Cerottini, R.R.A., Identification, enumeration and isolation of T and B lymphocytes from human peripheral blood, Clin. Immunol. Immunopathol. 3: 584 (1975).
H.J. Allen, Frequency distribution analysis of the normal lymphocyte response to phytohemagglutinin, Immun. Comm. 3: 577 (1974).
R.I. Lehrer and M.J. Cline, Interaction of C. albicans with human leukocytes and serum, J. Bacteriol. 3, 98: 996 (1969).
E. Preisig, W.H. Hitzig, NBT test for detection of C.G.D. technical modification, Europ. J. Clin. Invest. 1: 409 (1971)
W.H. Wickett Jr., L.J. Bradshaw, J. Wilson, and A.J. Glasky Clinical effectiveness of the immunopotentiating agent, Inosiplex, in herpes virus infections, Abstracts of 76th Annual Meeting of the American Society for Microbiology - Atlantic City, New Jersey, May 5 (1976).
J.H. Bouffaut and J.H. Saurat, Isoprinosine as a therapeutic agent in recurrent mucocutaneous infections due to herpes virus, Abstracts of the First International Conference on Immunopharmacology, Brighton, England, July 29–August 1 (1980)
L.M. Lao, M.L. Montes-Lao, and Z. Gonzales, Chemotherapy of viral infection, Philippine J. Microbiol. Infect. Pis. 6 (1): 35 (1977).
J. Ink, F.J. Andres, G.M. Antonini, J.C. Stefano, V. Scarpiello, C. Vaninetti, R.L. Ink, N.H. De Vila Ink, and I. Goijman, Estudio clinico bioestadistico de diferentes virosis tratadas con p-acetamidobenzoato de dimetilamino-isopropanol inosina, Presna Med. Argent. 58: 1867 1971 ).
B.M. Limson, Methisoprinol in the treatment of non-bacterial pharyngitis, Philippine J. Microbiol. Infect. Pis. 1 (1): 21 (1972).
A. Lazzarin, F. Capsoni, M.R. Zocchi, P. Candiani, P. Monteni, and M. Moroni, Polymorphonuclear leukocyte function in burned patients: effect of Isoprinosine, Att del 3th International Congress of Pharmacological Treatment of Burns, 13/14 maggio 1980 Milano Ed, Minerva Chirurgica.
F. Patrone and F. Dallegri, Stimulation of neutrophils locomotion by inosiplex, Int. Archs. Allergy Appl. Immun. 62: 221 (1980).
A. Lazzarin, R. Esposito, and M. Almaviva, Modifications of leucocyte function in visceral leishmaniasis, Boll. 1st Sieroter. Milanese 60 (3): 222 (1981).
L. Donati, M. Moroni, P. Candiani, A. Lazzarin, M. Klinger, and M. Signorini, Value of immunostimulant drugs in the treatment of burns, Riv. Ital. Chirurgia Plastica 13: 82 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Galli, M., Lazzarin, A., Moroni, M., Zanussi, C. (1984). Treatment of Recurrent Viral Infectious Diseases by Methisoprinol. In: Fudenberg, H.H., Whitten, H.D., Ambrogi, F. (eds) Immunomodulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9358-4_27
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9358-4_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9360-7
Online ISBN: 978-1-4615-9358-4
eBook Packages: Springer Book Archive