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Serologic Tests for the Detection of Human Immunodeficiency Virus Infection

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AIDS Testing

Abstract

Persons infected with the human immunodeficiency virus (HIV) have a spectrum of clinical features, ranging from persons who are infected but appear completely healthy to those with rapid disease progression and mortality. All groups, regardless of clinical stage, possess several biologic indicators of viral infection or replication (Figure 5.1). These include viremia, antibodies against viral proteins, circulating viral proteins, and nonspecific markers such as neopterin, beta2-microglobulins, and T4 cell counts. A variety of immunologic tests currently exists for the detection of viral antibodies and protein antigens. These assays have permitted testing programs to protect the blood supply from infected units and to conduct seroprevalence surveys to define the epidemic. More recently, the presence or absence of viral and nonspecific markers have been used to predict the onset of clinical disease.

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Authors
  1. J. Richard George
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  2. Gerald Schochetman
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Editors and Affiliations

  1. Laboratory Investigations Branch Division of HIV/AIDS, National Center for Infectious Diseases Centers for Disease Control, Atlanta, GA, 30333, USA

    Gerald Schochetman Ph.D. (Chief) (Chief)

  2. Developmental Technology Section Laboratory Investigations Branch Division of HIV/AIDS, National Center for Infectious Diseases Centers for Disease Control, Atlanta, GA, 30333, USA

    J. Richard George Ph.D. (Chief) (Chief)

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George, J.R., Schochetman, G. (1992). Serologic Tests for the Detection of Human Immunodeficiency Virus Infection. In: Schochetman, G., George, J.R. (eds) AIDS Testing. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0514-9_5

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  • DOI: https://doi.org/10.1007/978-1-4684-0514-9_5

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