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Defective Interfering Animal Viruses

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Comprehensive Virology 10

Abstract

Defective interfering (DI) particles were discovered three decades ago by von Magnus (1947) using the influenza virus system. He called them “incomplete” or “immature” particles. Even though they could not be isolated or characterized biochemically, a great deal was learned about them from their physiological interactions with the host and from their interference with the multiplication of “infectious” standard virus (Gard and von Magnus, 1947; Bernkopf, 1950; von Magnus, 1951). Reviews by Henle (1950), by von Magnus (1954), and by Schlesinger (1959) on viral interference discuss the earlier work on this particular homologous interference caused by incomplete virus.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Alice S. Huang

  2. Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    David Baltimore

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  1. Alice S. Huang
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  1. Department of Molecular Biology and Virus Laboratory, University of California, Berkeley, California, USA

    Heinz Fraenkel-Conrat

  2. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Robert R. Wagner

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Huang, A.S., Baltimore, D. (1977). Defective Interfering Animal Viruses. In: Fraenkel-Conrat, H., Wagner, R.R. (eds) Comprehensive Virology 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0832-4_2

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