Abstract
It should be made clear at once that the nature of the ensuing discussion is deliberately limited. Consideration of the effects of alcohols on cerebral neurons (or stated another way, cerebral effects of alcohols at the cellular and subcellular levels) necessitates taking a quite specific point of view. The latter is based on certain assumptions, some of which can be stated, as well as on the setting up of arbitrary limits or boundaries with regard to both data and theory (or, depending on the degree of libidinal investment, with regard to both fact and fancy). The limits are particularly obvious if the concept of “behavior” is involved; this is certainly the primary interest of psychiatrists and psychologists dealing with the use of alcohol consumed either occasionally or chronically. For present purposes, i.e., in the neurophysiologic or neurobiologic frame of reference, behavior is also a central issue, but in more than the usual sense. The neurophysiologist, in other words, hopes, in time, to understand the effects of alcohol on the total organism (alone and in its relationships to others), but focuses his investigative efforts on least suborders of behaviors:
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1.
Effects of alcohols on the integrated activity of the nervous system
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2.
Effects of alcohols on behavior of specific of the central nervous system
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3.
Effects of alcohols on behavior of the neuron (the functional unit of the nervous system) and its junctions with other neurons.
This chapter was written in the spring of 1970.
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References
Abood, L. G.: 1966. Intern. Rev. Neurobiol. 9: 223.
Abood, L. G.: 1969. Calcium—ATP-lipid interactions and their significance in the excitatory membrane, in Neurosciences Research, S. Ehrenpreis and O. C. Solnitzky, eds. Vol. 2, pp. 41–70, Academic Press, New York.
Armstrong, C. M. and Binstock, K.: 1964. The effects of several alcohols on the properties of the squid giant axon, J. Gen. Physiol. 48: 265–277.
Arvanitaki, A. and Chalazonitis, N. 1951. Effets narcotiques sur les bipotentiels neuroniques et sur la cataluse respiratorie, in Mécanismes de la Narcose, CNRS, Paris, France.
Baker, P. F., Blaustein, M. P., Keynes, R. D., Manil, J., Shaw, I. I., and Steinhardt, R. A.: 1969. The ouabain-sensitive fluxes of sodium and potassium in squid giant axons, J. Physiol. 200: 459–496.
Battey, L. L. and Heyman, H. 1953. Effects of ethyl alcohol on cerebral blood flow and metabolism, JAMA 152: 6–10.
Beer, C. T. and Quastel, J. H.: 1958. The effects of aliphatic alcohols on the respiration of rat brain cortex slices and rat mitochondria, Canad. J. Biochem. Physiol. 36: 543–556.
Birks, R. I.: 1963. The role of sodium ions in the metabolism of acetylcholine, Canad. J. Biochem. Physiol. 41: 2573–2597.
Brink, F.: 1951. in Handbook of Experimental Psychology (S. S. Stevens, ed.), Chapter 2. John Wiley and Sons, New York.
Davies, P. W. and Grenell, R. G.: 1962. Metabolism and function in the cerebral cortex under local perfusion, with the aid of an oxygen cathode for measuring surface Q02., J. Neurophysiol. 25: 651.
Diamond, J. M. and Wright, E. M.: 1969. Biological membranes.: The physical basis of ion and nonelectrolyte selectivity, Am. Rev. Physiol. 31: 581–646.
Featherstone, R. M. and Muehlbaecher, C. A.: 1966. Mol. Pharmacol. 2: 495.
Frankenhaeuser, B. and Hodgkin, A. L.: 1957. The action of calcium on the electrical properties of squid axons, J. Physiol. (London) 137: 218–244.
Gallego, A.: 1948. On the effect of ethyl alcohol upon frog nerve, J. Cell. Comp. Physiol. 31: 97–106.
Graham, H. T.: 1929. The narcosis of muscle by gases, J. Pharmacol. Exptl. Therap. 37: 9.
Grenell, R. G., Mendelson, J., and McElroy, W. D.: 1955. Neuronal metabolism and ATP synthesis in narcosis, J. Cell. Comp. Physiol. 46: 143–162.
Grenell, R. G.: 1957. Some effects of alcohols on the central nervous system, in Alcoholism (H. Himwich, ed.) pp. 7–17 Pub. No. 47, Washington, D.C.
Grenell, R. G.: 1959. Alcohols and activity of cerebral neurons, Quart. J. Stud. Alc. 20: 421–427.
Grenell, R. G.: unpublished.
Grenell, R. G. and Romero, E. G.: to be published.
Hensel, H. and Zotterman, Y.: 1951. Effect of menthol on the thermoreceptors, Acta Physiol. Scand. 24: 27.
Israel, Y., Kalant, H., and Laufer, I.: 1965. Effects of ethanol on Na+-K+-Mg+ + stimulated microsonal ATPase activity, Biochem. Pharmacol. 14: 1803–1814.
Israel, Y.: Kalant, H.: and LeBlanc, A. E.: 1966. Effects of lower alcohols on potassium transport and microsomal ATPase activity of rat cerebral cortex, Biochem. J. 100: 27–33.
Israel, Y. and Salazar, I.: 1967. Inhibition of brain microsomal ATPases by general depressants, Arch. Biochem. Biophys. 122: 310–316.
Kalant, H., Israel, Y., and Mahon, M. A., 1967. The effect of ethanol on acetylcholine synthesis released and degradation in the brain, Canad. J. Physiol. Pharmacol. 45: 172–176.
Katz, B.: 1962. Proc. Roy. Soc. B. 155: 455.
Kwan, E. and Trevor, A.: 1969. The association of xenon with subcellular components of rat cerebral cortex, Mol. Pharmacol. 5: 236–243.
Larrabee, M. G., Garcia Ramos, J., and Bulbring, E.: 1950. Do anesthetics depress nerve cells by depressing oxygen consumption? Fed. Proc. 9: 75.
Larrabee, M. G.: Garcia Ramos, J.: and Bulbring, E.: 1952. Effects of anesthetics on oxygen consumption and on synaptic transmission in sympathetic ganglia, J. Cell. Comp. Physiol. 40: 461–494.
Lindholm, R. and Wallgren, H.: 1962. Changes in respiration of rat brain cortex slices induced by some aliphatic alcohols, Acta Pharm. Tox. Kbh. 19: 53–58.
Masserman, J. H. and Jacobson, L.: 1940. Effects of ethyl alcohol on the cerebral cortex and the hypothalamus of the cat, Arch. Neurol. Psychiat. Chic. 43: 334–340.
Masserman, J. H.: 1940. Stimulant effects of ethyl alcohol in corticohypothalamic functions, J. Pharmac. 70: 450–453.
Mendelson, J.: 1968. Biochemical pharmacology of alcohol, in Psychopharmacology (D. H. Efron, ed.) pp. 769–786, Public Health Serv. Publication No. 1836, Washington, D.C.
Mendelson, J. and Grenell, R. G.: 1954. Effects of narcotics on direct acetylation of sulfanilamide, Science 120: 802–803.
Moore, J. W.: Ulbricht, W.: and Takata, M.: 1964. Effect of ethanol on the sodium and potassium conductances of the squid axon membrane, J. Gen. Physiol. 48: 279–295.
Mullins, L. J.: 1954. Some physical mechanics in narcosis, Chem. Rev. 54: 289–323.
Mullins, L. J.: 1968. From molecules to membranes, Fed. Proc. 27: 898–901.
Mullins, L. J. and Gaffey, C. T.: 1954. Proc. Soc. Exp. Biol Med. 85: 44.
McCulloch, D. and Grenell, R. G.: to be published; NASA reports, 1967–1969, Grant No. NGR 21-002-040, Office of Biosciences.
McIlwain, H.: 1953. The effect of depressants on the metabolism of stimulated cerebral tissues, Biochem. J. 53: 403–411.
Pauling, L.: 1961. A molecular theory of general anesthesia, Science 134: 15–21.
Quastel, J. H.: 1959. Effect of aliphatic alcohols on the metabolism of brain and liver, Quart J. Studies Alc. 20: 428.
Raskin, N. H. and Sokoloff, L.: 1968. Brain alcohol dehydrogenase, Science 162: 131.
Schoenborn, B. P. and Nobbs, C. L. 1966. Mol Pharmacol. 2: 495.
Schoenborn, B. P. and Featherstone, R. M.: 1967. Advan. Pharmacol. 5: 1.
Truitt, E. B.: Jr.: Ball, F. K.: and Krantz, J. C.: Jr.: 1956. Anesthesia L III. Effects of alcohols and aldehydes on oxidative phosphorylation in brain, Quart. J. Studies Alc. 17: 594.
Ueda, I. and Mietani, U.: 1967. Microsomal ATPase of rabbit brain and effects of general anesthetics., Biochem. Pharmacol. 16: 1370–1374.
Wallgren, H. and Kulonen, E.: 1960. Effect of ethanol on respiration of rat brain cortex slices, Biochem. J. 75: 150–158.
Wallgren, H.: 1963. Rapid changes in creatine and adenosine phosphates of cerebral cortex slices on electrical stimulation with special reference to the effect of ethanol, J. Neurochem. 10: 349–358.
Wiener, N.: 1961. The content of adenine nucleotides and creatine phosphate in brain of normal and anesthetized rats.: a critical study of some factors influencing their assay, J. Neurochem. 7: 241–250.
Williams, S.: Paterson, R. A.: and Health, H.: 1968. The effects of B-B’-iminod.: propionitrile and anesthesia on some adenine nucleotides of rat brain and retina, J. Neurochem. 15: 227.
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© 1972 Plenum Press, New York
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Grenell, R.G. (1972). Effects of Alcohol on the Neuron. In: Kissin, B., Begleiter, H. (eds) The Biology of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0895-9_1
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