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Conversion of Angiotensin I to II In Vivo and In Vitro

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Control of Renin Secretion

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 17))

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Abstract

It has long been believed that the conversion of the inactive decapeptide hormone angiotensin I (AI) to angiotensin II (AII) was mediated by a plasma dicarboxypeptidase (1). More recently the provocative experiments of Ng and Vane (2) suggested that the major site of conversion was the pulmonary circulation and that conversion in plasma could not account for the rapid pressor response to an intravenous injection of AI.

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References

  1. Skeggs, L.J., Kahn, J.R., and Shumway, N.P.: Preparation and function of the hypertension-converting enzyme. J. Exp. Med. 103: 295, 1956.

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  2. Ng, K.K.F., and Vane, J.R.: Conversion of angiotensin I to angiotensin II. Nature(London) 216: 762, 1967.

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  3. Oparil, S., Sanders, C.A., and Haber, E.: In-vivo and in-vitro conversion of angiotensin I to angiotensin II in dog blood. Circulation Res. 26: 591, 1970.

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  4. Oparil, S., Tregear, G.W., Koerner, T., Barnes, B.A., and Haber, E.: Mechanism of pulmonary conversion of angiotensin I to angiotensin II in the dog. In press. Circulation Res.

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  5. Haber, E., Koerner, T., Page, L.B., Kliman, B., and Purnode, A.: Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects: renin activity by angiotensin I radioimmunoassay. J. Clin. Endocr. 29: 1349, 1969.

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  6. Page, L.B., Haber, E., Kimura, A.Y., and Purnode, A.: Studies with the radioimmunoassay for angiotensin II and its application to measurement of renin activity. J. Clin. Endocr. 29: 200, 1969.

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© 1972 Plenum Press, New York

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Oparil, S., Haber, E. (1972). Conversion of Angiotensin I to II In Vivo and In Vitro . In: Assaykeen, T.A. (eds) Control of Renin Secretion. Advances in Experimental Medicine and Biology, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0940-6_13

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  • DOI: https://doi.org/10.1007/978-1-4684-0940-6_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0942-0

  • Online ISBN: 978-1-4684-0940-6

  • eBook Packages: Springer Book Archive

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