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Neurofilament Transport in Axonal Regeneration

Implications for the Control of Axonal Caliber

  • Chapter
Axonal Transport in Neuronal Growth and Regeneration

Part of the book series: Advances in Neurochemistry ((ANCH,volume 22))

Abstract

Regenerating axons have been intensively studied with regard to the mechanisms and determinants of elongation, and several lines of evidence suggest that the delivery of cytoskeletal proteins (tubulin and actin, in particular) are correlates of outgrowth and may be rate limiting (see Lasek and Hoffman, 1976; Wujck and Lasek. 1983). In addition lo changes in axonal length, regeneration involves marked changes in axonal caliber and in cytoskeletal composition. The rcgcneraling axon provides the best available system in which to test critically the hypotheses underlying several of our recent studies. These hypotheses are that neurofilament content is the major correlate of axonal caliber and that axonal neurofilament content is, in turn, determined, in large part, by neurofilament delivery via slow axonal transport. This review will first summarize the general problem of the determinants of axonal caliber and then focus on recent data from regenerating nerves. These data can be considered in terms of three regions of the regenerating axon—the proximal stump, the maturing sprouts, and the distal sprouts.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Paul N. Hoffman

  2. Departments of Neurology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    John W. Griffin

  3. Departments of Pathology, Neurology, and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Donald L. Price

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  1. Paul N. Hoffman
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  2. John W. Griffin
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  3. Donald L. Price
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Editor information

Editors and Affiliations

  1. Florida State University, Tallahassee, Florida, USA

    John S. Elam  & Paul Cancalon  & 

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© 1984 Plenum Press, New York

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Hoffman, P.N., Griffin, J.W., Price, D.L. (1984). Neurofilament Transport in Axonal Regeneration. In: Elam, J.S., Cancalon, P. (eds) Axonal Transport in Neuronal Growth and Regeneration. Advances in Neurochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1197-3_14

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  • DOI: https://doi.org/10.1007/978-1-4684-1197-3_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1199-7

  • Online ISBN: 978-1-4684-1197-3

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