Summary
Histological studies were done by light and electron microscopy to improve biological tests used to evaluate the pharmacological properties of RU 486. The compound prevented the progesterone-induced appearance of giant mitochondria in uterine glandular cells in ovariectomized rats and did not show any progestogen-mimetic effect. Its antiprogestational activity was demonstrated by abortion in rats where RU 486-induced changes in the deciduoma cells could be observed, even prior to the changes caused by ovariectomy. The hypertrophic effect of RU 486 on the uterus of immature animals was distinguished from the hyperplastic effect of estradiol.
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References
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© 1985 Plenum Press, New York
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Secchi, J., Lecaque, D., Tournemine, C., Philibert, D. (1985). Histopharmacology of RU 486. In: Baulieu, EE., Segal, S.J. (eds) The Antiprogestin Steroid RU 486 and Human Fertility Control. Reproductive Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1242-0_6
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DOI: https://doi.org/10.1007/978-1-4684-1242-0_6
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-1244-4
Online ISBN: 978-1-4684-1242-0
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