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Effects of Gonadal Hormones on Plasma Renin Activity and Aldosterone Excretion Rate

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Metabolic Effects of Gonadal Hormones and Contraceptive Steroids

Abstract

We have reported elsewhere (1) that the administration of ethinyl estradiol increased plasma renin activity (PRA) and aldosterone excretion rate. We were led to make these observations because of the findings of a markedly increased PRA in a normal subject who was taking Orthonovum for contraceptive purposes. Her PRA decreased to normal after the oral contraceptive was discontinued.

Career Development Awardee K3-HE-7627 of the National Institutes of Health of the USPHS.

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References

  1. Crane, M.G., Heitsch, J., Harris, J., and Johns, V.J., Jr.: Effect of ethinyl estradiol (Estinyl) on plasma renin activity. J. Clin. Endocr. 26:1403 (1966).

    Article  CAS  Google Scholar 

  2. Helmer, O.M., and Judson, W.E.: Influence of high renin substrate levels on renin-angiotensin system in pregnancy. Amer. J. Obstet. Gynec. 99:9–17 (1967).

    PubMed  CAS  Google Scholar 

  3. Laragh, J.H., Sealey, J.E., Ledingham, J.G.G., and Newton, M.A.: Oral contraceptives, renin, aldosterone and high blood pressure. J.A.M.A. 201:918–922 (1967).

    Article  PubMed  CAS  Google Scholar 

  4. Boucher, R., Veyrat, R., de Champlain, J., and Genest, J.: New procedures for measurement of human plasma angiotensin renin activity levels. Canad. Med. Ass. J. 90:194 (1964).

    PubMed  CAS  Google Scholar 

  5. Cohen, E.L., Conn, J.W., and Rovener, D.R.: Postural augmentation of plasma renin activity and aldosterone excretion in normal people. J. Clin. Invest. 46:418 (1967).

    Article  PubMed  CAS  Google Scholar 

  6. Kliman, B., and Peterson, R.E.: Double isotope derivative assay of aldosterone in biological extracts. J. Biol. Chem. 235:1639 (1960).

    PubMed  CAS  Google Scholar 

  7. Laidlaw, J.C., Ruse, J.L., and Gomall, A. G.: The influence of estrogen and progesterone on aldosterone excretion. J. Clin. Endocr. 22:161 (1962).

    Article  PubMed  CAS  Google Scholar 

  8. Layne, D.S., Meyer, C.J., Vaishwanar, P.S., and Pincus, G.: The secretion and metabolism of Cortisol and aldosterone in normal and in steroid treated women. J. Clin. Endocr. 22:107 (1962).

    Article  PubMed  CAS  Google Scholar 

  9. Helmer, O.M., and Griffith, R.S.: The effect of the administration of estrogens on the renin-substrate (hypertensinogen) content of rat plasma. Endocrinology 51:421 (1952).

    Article  PubMed  CAS  Google Scholar 

  10. Chagoya, L., Nurko, B., Santos, E., and A. Rivera: 6- chloro, 6-dehydro, 17 a-acetoxyprogesterone: its possible action as an aldosterone antagonist. J. Clin. Endocr. 21:1364 (1961).

    Article  PubMed  CAS  Google Scholar 

  11. Landau, R.L., Lugibihl, K., and Dimick, D.F.: Metabolic effects in man of steroids with progestational activity. Ann. New York Acad. Sc. 71:588 (1958).

    Article  CAS  Google Scholar 

  12. Weinberger, M.H., Dowdy, A.J., Nokes, G.W., and Luetscher, J.A.: Reversible increases in plasma renin activity, aldosterone secretion, and blood pressure in women taking oral contraceptive preparations. Clin. Res. 16:150 (1968).

    Google Scholar 

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© 1969 Plenum Press, New York

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Crane, M.G., Harris, J.J. (1969). Effects of Gonadal Hormones on Plasma Renin Activity and Aldosterone Excretion Rate. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_32

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  • DOI: https://doi.org/10.1007/978-1-4684-1782-1_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1784-5

  • Online ISBN: 978-1-4684-1782-1

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