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Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord

  • Chapter
Amino Acid Neurotransmitters

Part of the book series: Handbook of Psychopharmacology ((SIBN,volume 4))

Abstract

Attempts to prove the identity of amino acid inhibitory transmitters in the mammalian central nervous system received fresh impetus when Florey (1954) extracted an inhibitory substance, factor I, from mammalian brain and subsequently (Bazemore et al., 1957) showed that it contained γ-aminobutyric acid (GABA). However, some active preparations of factor I do not contain GABA (McLennan, 1958). In some of the earliest studies (Honour and McLennan, 1960; McLennan, 1957) it was found that a topical application of GABA to the exposed spinal cord did not reduce spinal monosynaptic reflexes even though effects were observed with factor I. This seemed to dampen enthusiasm for GABA as a central transmitter somewhat, but it was later found by other workers that higher concentrations were effective.

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Authors and Affiliations

  1. Department of Pharmacology, University of Cambridge, Cambridge, England

    Ronald W. Ryall

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  1. Ronald W. Ryall
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Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, UK

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medical, USA

    Solomon H. Snyder

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© 1975 Plenum Press, New York

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Ryall, R.W. (1975). Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Amino Acid Neurotransmitters. Handbook of Psychopharmacology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3174-2_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3174-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3176-6

  • Online ISBN: 978-1-4684-3174-2

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