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The Antileprosy Agent Clofazimine (B.663) in Macrophages: Light, Electron Microscope and Function Studies

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The Reticuloendothelial System and Immune Phenomena

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 15))

Abstract

In 1957 in a communication from these laboratories the remarkable antimycobacterial activity of B.663, 3-(P.-chloroanilino)-10-(P.-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine, was first described (1). B.663, now known as Clofazimine, forms the active component of the antileprosy preparation Lamprene (Geigy).

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Author information

Authors and Affiliations

  1. Laboratories, Medical Research Council of Ireland Trinity College, Dublin, Ireland

    M. L. Conalty & A. G. Jina

Authors
  1. M. L. Conalty
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  2. A. G. Jina
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Editor information

Editors and Affiliations

  1. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Nicholas R. Di Luzio

  2. Institute of Biophysics and Radiation Biology, University of Freiburg, Freiburg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

  3. Department of Pharmacology and Radiobiology, Heiligenberg Institute, Heiligenberg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

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© 1971 Plenum Press, New York

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Conalty, M.L., Jina, A.G. (1971). The Antileprosy Agent Clofazimine (B.663) in Macrophages: Light, Electron Microscope and Function Studies. In: Di Luzio, N.R., Flemming, K.B.P. (eds) The Reticuloendothelial System and Immune Phenomena. Advances in Experimental Medicine and Biology, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3204-6_33

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  • DOI: https://doi.org/10.1007/978-1-4684-3204-6_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3206-0

  • Online ISBN: 978-1-4684-3204-6

  • eBook Packages: Springer Book Archive

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