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Reaction Patterns of Intimal Mesenchyme to Injury, and Repair in Atherosclerosis

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Arterial Mesenchyme and Arteriosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 43))

Abstract

The role of the arterial wall itself in the inception and progression of atherosclerotic lesions had been disregarded for many decades. It became apparent, however, that one had to take into consideration factors pertaining to the organ in which atherosclerotic tissue changes took place, if one hoped to account ultimately for all features of the disease process. For example, the striking variations in the degree and extent of involvement and type of atherosclerotic lesions in different arteries or in various segments of the same artery, and the range in severity in different individuals of the same age group or in the many populations of the world, cannot be accounted for by any one theory on the etiology and pathogenesis of atherosclerosis (Haust and More, 1972), or by the more modern approach of “grouping” of factors, such as those referring to several blood constituents or to hemodynamics (Haust, 1971a). The key issue is then, if by taking into consideration the factors of arterial wall at least some of the remaining problems can be solved.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Western Ontario, London, Ontario, Canada

    M. Daria Haust

  2. Sir William Dunn School of Pathology, University of Oxford, Oxford, Great Britain

    M. Daria Haust

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  1. M. Daria Haust
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Editors and Affiliations

  1. Department of Comparative Medicine, Arteriosclerosis Research Center, The Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA

    William D. Wagner  & Thomas B. Clarkson  & 

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© 1974 Plenum Press, New York

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Haust, M.D. (1974). Reaction Patterns of Intimal Mesenchyme to Injury, and Repair in Atherosclerosis. In: Wagner, W.D., Clarkson, T.B. (eds) Arterial Mesenchyme and Arteriosclerosis. Advances in Experimental Medicine and Biology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3243-5_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3243-5_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3245-9

  • Online ISBN: 978-1-4684-3243-5

  • eBook Packages: Springer Book Archive

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