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New Animal Model for Atherosclerosis Research

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Lipids, Lipoproteins, and Drugs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 63))

Summary

Japanese quail were investigated for their utility as a model for the discovery and evaluation of anti-atherosclerosis compounds. Although they possessed suitable characteristics for a screening animal, their development of atherosclerosis was too variable to make them a practical model. A search was conducted to find a means to make quail uniformly atherosclerotic. To this end a line of quail susceptible to experimental atherosclerosis (SEA) were selectively bred. Thus, the SEA Japanese quail is a new animal model for atherosclerosis research.

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References

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Author information

Authors and Affiliations

  1. Diabetes and Atherosclerosis Research, The Upjohn Company, Kalamazoo, Michigan, USA

    Charles E. Day & Walter W. Stafford

Authors
  1. Charles E. Day
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  2. Walter W. Stafford
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Editor information

Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

  3. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes

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© 1975 Plenum Press, New York

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Day, C.E., Stafford, W.W. (1975). New Animal Model for Atherosclerosis Research. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Lipids, Lipoproteins, and Drugs. Advances in Experimental Medicine and Biology, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3258-9_24

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  • DOI: https://doi.org/10.1007/978-1-4684-3258-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3260-2

  • Online ISBN: 978-1-4684-3258-9

  • eBook Packages: Springer Book Archive

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