Abstract
For the past 15 years or so, I have been providing evidence that polypeptide hormones stimulate hormone-specific species of glucose-6-phosphate dehydrogenase (Glc-6-PD) in their target tissues. This allosteric regulation of the rate-limiting enzyme of the pentose phosphate cycle provides reducing equivalents for biosynthetic purposes. In addition, it provides ribose sugars such as 5-phospho-d-ribosyl pyrophosphate (5-PRPP) that are rate-limiting to the synthesis de novo of purine and pyrimidine nucleotides. These nucleotides are required in the synthesis of RNA and DNA and in electron- and energy-carrying compounds, such as NADPH and ATP.
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Abbreviations
- Glc6-PD:
-
Glucose-6-phosphate dehydrogenase
- G-6P:
-
glucose-6-phosphate
- hCG:
-
human choriogonadotropin
- LH:
-
lutropin
- mRNA:
-
messenger RNA
- 5-PRPP:
-
5-phospho-d-ribosylpyrophosphate
References
Criss, E. E., and Mckems,K. W., 1968, Activation of cow adrenal glucose-6-phosphate dehydrogenase by adrenal corticotropin, Biochemistry 7: 2364–2368.
Criss, W. E., and McKerns, K. W., 1969, Studies on ACTH-induced changes at the NADP`-binding site of bovine adrenal glucose-6-phosphate dehydrogenase, Arch. Biochem. 135:118.
McKems, K. W., 1964, Mechanism of action of ACTH through activation of glucose-6phosphate dehydrogenase, Biochim. Biophys. Acta 90: 357–371.
McKerns, K. W., 1967, Genetic, biochemical and hormonal mechanisms in the regulation of uterine metabolism in: Cellular Biology of the Uterus (R. M. Wynn, ed.), pp. 71–113, Appleton-Century-Crofts, New York.
McKerns, K. W., 1968, Mechanism of ACTH regulation of adrenal cortex, in: Functions of the Adrenal Cortex, pp. 479–533, Appleton-Century-Crofts, New York.
McKerns, K. W., 1969a, Steroid Hormones and Metabolism, Appleton-Century-Crofts, New York.
McKerns, K. W., 1969b, Studies on the regulation of ovarian function by gonadotropin, in: The Gonads ( K. W. McKerns, ed.), Appleton-Century-Crofts, New York.
McKerns, K. W., 1973a, ACTH stimulation of purine nucleotide biosynthesis in the adrenalcortex, Arch. Biochem. Biophys. 154: 341.
McKerns, K. W., I973b, Gonadotropin regulation of nucleotide biosynthesis in corpus luteum, Biochemistry 12: 5206–5211.
McKerns, K. W., 1976, Genetic, biochemical and hormonal mechanisms in the regulation of the uterus, in: Cellular Biology of the Uterus (R. M. Wynn, ed.), pp. 101–138, Plenum Press, New York.
McKerns, K. W., and Ryschkewitsch, W., 1974, Interaction of luteinizing hormone and its subunits in corpus luteum supernatant, Endocrinology 95: 847–853.
McKerns, K. W., and Ryschkewitsch, W., 1976, Regulation of RNA synthesis in corpora
lutea by luteinizing hormone and derivatives, Biochim. Biophys. Acta 454:51–54. McKerns, K. W., and Ryschkewitsch, W., 1977, Lutropin stimulation of RNA synthesis in corpus luteum chromatin, Biochim. Biophys. Acta 478:68–74.
Péron, F. G., and Caldwell, B. V., 1968, Further studies on corticosteroidogenesis. V. 1lß-Hydroxylation of DOC by mitochondria incubated with malate supernatant fraction and supernatant fraction + pyruvate + CO2, Biochim. Biophys. Acta 164: 396.
Schwyzer, R., and Schiller, P. W., 1969, The role of adenyl cyclase and cyclic 3’,5’-AMP in biological systems, Fogarty Int. Center Proc., No. 4 (Nov. 17–19), pp. 105–111, Bethesda, Maryland.
Simpson, E. R., Cammer, W., and Estabrook, R. W., 1968, The role of malic enzyme in bovine adrenal cortex mitochondria, Biochem. Biophys. Res. Commun. 31:113.
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© 1978 Plenum Press, New York
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McKerns, K.W. (1978). Regulation of Gene Expression in the Nucleus by Gonadotropins. In: McKerns, K.W. (eds) Structure and Function of the Gonadotropins. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3414-9_14
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DOI: https://doi.org/10.1007/978-1-4684-3414-9_14
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