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The Dual Specificity of Virus-Immune T Cells

Functional Indications That Virus and H-2 Molecules May Associate on the Cell Membrane

  • Chapter
Current Trends in Histocompatibility

Abstract

A current obsession of cellular immunology is the definition of the T-cell receptor repertoire. Many of the questions that have been raised derive from experiments with virus systems (Doherty et al., 1976a; Zinkernagel and Doherty, 1979). How do we explain the apparent dual specificity for major histocompatibility (MHC) components and for virus?

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104, USA

    Peter C. Doherty, Jack R. Bennink, Rita B. Effros & Mark Frankel

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  1. Peter C. Doherty
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  2. Jack R. Bennink
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  1. Scripps Clinic and Research Foundation, La Jolla, California, USA

    Ralph A. Reisfeld  & Soldano Ferrone  & 

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Doherty, P.C., Bennink, J.R., Effros, R.B., Frankel, M. (1981). The Dual Specificity of Virus-Immune T Cells. In: Reisfeld, R.A., Ferrone, S. (eds) Current Trends in Histocompatibility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3761-4_3

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