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Histamine Receptors in Brain

  • Chapter
Biochemical Studies of CNS Receptors

Part of the book series: Handbook of Psychopharmacology ((HBKPS))

Abstract

While mounting evidence is elevating histamine to the category of a putative neurotransmitter, its explicit functions in brain remain as unclear as those of most other putative neurotransmitters. Evidence has been reviewed (Green et al., 1978a; Schwartz, 1979, Schwartz et al., 1980a,b; Hough and Green, 1980) that it may function in arousal, locomotor activity, regulation of hunger and thirst, emesis, thermoregulation, and the elaboration of hormones, most persuasively, of prolactin and the antidiuretic hormone. There is also evidence, too rich to review here, that histamine may alter the formation, release, or activities of other endogenous substances. As provocative as many of these observations are, they remain to be integrated into coherent hypotheses, as do observations on other biogenic amines. The development of methods to measure histamine metabolism (Hough et al., 1981) offers an opportunity to evaluate further the functions of histamine in brain. Methods to study brain histamine receptors provide additional means of assessing the roles of histamine in brain. A description of these receptors, some of their associated effects, and their response to psychotropic drugs is presented in this review.

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  1. Department of Pharmacology, Mount Sinai School of Medicine, The City University of New York, New York, New York, 10029, USA

    Jack Peter Green

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  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, UK

    Susan D. Iversen

  3. Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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Green, J.P. (1983). Histamine Receptors in Brain. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Biochemical Studies of CNS Receptors. Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4361-5_8

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