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Tissue and Species Specificity for Phorbol Ester Receptors

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Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

Tumor promoters are agents that, although not themselves carcinogenic, induce tumors in animals previously treated with a subthreshold dose of a carcinogen (1–3). Although tumor promotion has been characterized in greatest detail for mouse skin, it has also been demonstrated for the liver, bladder, colon, trachea, and mammary gland (4,5). The potential importance of tumor promotion in human cancer etiology is suggested by a growing body of epidemiological evidence (6–8).

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References

  1. Boutwell, R.K. 1964. Some biological aspects of skin carcinogenesis. Prog. Exp. Tumor Res. 4: 207–250.

    PubMed  CAS  Google Scholar 

  2. Scribner, J.D., and R. Suss. 1978. Tumor initiation and promotion. Int. Rev. Exp. Pathol. 18: 137–198.

    PubMed  CAS  Google Scholar 

  3. Van Duuren, B.L. 1969. Tumor—promoting agents in two-stage carcinogenesis. Prog. Exp. Tumor Res. 11: 31–68.

    PubMed  Google Scholar 

  4. Farber, E., and R. Cameron. 1980. The sequential analysis of cancer development. Adv. Cancer Res. 31: 125–226.

    Article  PubMed  CAS  Google Scholar 

  5. Sivak, A. 1979. Cocarcinogenesis. Biochim. Biophys. Acta 560: 67–89.

    PubMed  CAS  Google Scholar 

  6. Cairns, J. 1981. The origin of human cancers. Nature 289: 353–357.

    Article  PubMed  CAS  Google Scholar 

  7. Day, N.E., and C.C. Brown. 1980. Multistage models and primary prevention of cancer. J. Natl. Cancer Inst. 64: 977–989.

    PubMed  CAS  Google Scholar 

  8. Higginson, J., and C.S. Muir. 1979. Environmental carcinogenesis: Misconceptions and limitations to cancer controls. J. Natl. Cancer Inst. 63: 1291–1298.

    PubMed  CAS  Google Scholar 

  9. Evans, F.J., and C.J. Soper. 1978. The tigliane, daphnane, and ingenane diterpenes, their chemistry, distribution, and biological activities: A review. Lloydia 41: 193–233.

    Google Scholar 

  10. Hecker, E. 1971. Isolation and characterization of the cocarcinogenic principles from croton oil. In: Methods in Cancer Research, Volume 6. H. Busch, ed. Academic Press: New York. pp. 439–484.

    Google Scholar 

  11. Goerttler, K., H. Loehrke, J. Schweizer, and B. Hesse. 1979. Systemic two–stage carcinogenesis in the epithelium of the forestomach of mice using 7,12–dimethylbenz[a]anthracene as initiator and the phorbol ester 12–O–tetradecanoylphorbol13–acetate as promoter. Cancer Res. 39: 1293–1297.

    PubMed  CAS  Google Scholar 

  12. Goerttler, K., H. Loehrke, and B. Hesse. 1980. Two–stage carcinogenesis in NMRI mice: Intravaginal application of 7,12–dimethylbenz[a]anthracene as initiator followed by the phorbol ester 12–0-tetradecanoylphorbol-13-acetate as promoter. Carcinogenesis 1: 707–713.

    Article  PubMed  CAS  Google Scholar 

  13. Goerttler, K., H. Loehrke, J. Schweizer, and B. Hesse. 1980. Two—stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12–dimethylbenz[a]anthracene and topical promotion with 12–0-tetradecanoylphorbol–13–acetate. Cancer Res. 40: 155–161.

    PubMed  CAS  Google Scholar 

  14. Blumberg, P.M. 1980. In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1. Crit. Rev. Toxicol. 8: 153–197.

    Article  Google Scholar 

  15. Blumberg, P.M. 1981. In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 2. Crit. Rev. Toxicol. 8: 199–234.

    Article  Google Scholar 

  16. Boutwell, R.K. 1974. The function and mechanism of promoters of carcinogenesis. Crit. Rev. Toxicol. 2: 419–443.

    Article  CAS  Google Scholar 

  17. Diamond, L., T.G. O’Brien, and W.M. Baird. 1980. Tumor promoters and the mechanism of tumor promotion. Adv. Cancer Res. 32: 1–74.

    Article  PubMed  CAS  Google Scholar 

  18. Driedger, P.E., and P.M. Blumberg. 1977. The effect of phorbol diesters on chicken embryo fibroblasts. Cancer Res. 37: 3257–3265.

    PubMed  CAS  Google Scholar 

  19. Weinstein, I.B., M. Wigler, and C. Pietropaolo. 1977. The action of tumor–promoting agents in cell culture. In: Origins of Human Cancer. H.H. Hiatt, J.D. Watson, and J.A. Winsten, eds. Cold Spring Harbor Laboratory: Cold Spring Harbor, NY. pp. 751–772.

    Google Scholar 

  20. Abrahm, J., and G. Rovera. 1980. The effect of tumor–promoting phorbol diesters on terminal differentiation of cells in culture. Molec. Cell. Biochem. 31: 165–175.

    Article  PubMed  CAS  Google Scholar 

  21. Dicker, P., and E. Rozengurt. 1979. Synergistic stimulation of early events and DNA synthesis by phorbol esters, polypeptide growth factors, and retinoids in cultured fibroblasts. J. Supramol. Struct. 11: 79–93.

    Article  PubMed  CAS  Google Scholar 

  22. Frantz, C.N., C.D. Stiles, and C.D. Scher. 1979. The tumor promoter 12–0–tetradecanoylphorbol–13–acetate enhances the proliferative response of BALB/c–3T3 cells to hormonal growth factors. J. Cell Phyiol. 100: 413–424.

    Article  CAS  Google Scholar 

  23. Weinstein, I.B., H. Yamasaki, M. Wigler, L.-S. Lee, P.B. Fisher, A. Jeffrey, and D. Grunberger. 1979. Molecular and cellular events associated with the action of initiating carcinogens and tumor promoters. In:

    Google Scholar 

  24. Carcinogens: Identification and Mechanisms of Action. A.C. Griffin and C.R. Shaw,. Raven Press: New York. pp. 399–418.

    Google Scholar 

  25. Blumberg, P.M., K.B. Delclos, W.G. Dunphy, and S. Jaken. (in press). Specific binding of phorbol ester tumor promoters to mouse tissues and cultured cells. In: Cocarcinogenesis and Biological Effects of Tumor Promoters. E. Hecker, ed. Raven Press: New York.

    Google Scholar 

  26. Delclos, K.B., D.S. Nagle, and P.M. Blumberg. 1980. Specific binding of phorbol ester tumor promoters to mouse skin. Cell 19: 1025–1032.

    Article  PubMed  CAS  Google Scholar 

  27. Driedger, P.E., and P.M. Blumberg. 1980. Specific binding of phorbol ester tumor promoters. Proc. Natl. Acad. Sci. USA 77: 567–571.

    Article  PubMed  CAS  Google Scholar 

  28. Dunphy, W.G., K.B. Delclos, and P.M. Blumberg. 1980. Characterization of specific binding of [3H]phorbol 12,13–dibutyrate and [3H]phorbol 12–myristate 13–acetate to mouse brain. Cancer Res. 40: 3635–3641.

    PubMed  CAS  Google Scholar 

  29. Dunphy, W.G., R.J. Kochenburger, M. Castagna, and P.M. Blumberg. 1981. Kinetics and subcellular localization of specific [3H]phorbol 12,13-dibutyrate binding by mouse brain. Cancer Res. 41: 2640–2647.

    PubMed  CAS  Google Scholar 

  30. Jaken, S., A.H. Tashjian, Jr., and P.M. Blumberg. 1981. Characterization of phorbol ester receptors and their down–modulation in GH4C1 rat pituitary cells. Cancer Res. 41: 2175–2181.

    PubMed  CAS  Google Scholar 

  31. Lew, K.K., S. Chritton, and P.M. Blumberg. (in press). Biological responsiveness to the phorbol esters and specific binding of [3H]phorbol 12,13–dibutyrate in the nematode Caenorhabditis elegans, a manipulable genetic system. Teratog. Carcinog. Mutag.

    Google Scholar 

  32. Nagle, D.S., S. Jaken, M. Castagna, and P.M. Blumberg. 1981. Variation with embryonic development and regional localization of specific [3H]phorbol 12,13–dibutyrate binding to brain. Cancer Res. 41: 89–93.

    PubMed  CAS  Google Scholar 

  33. Lee, L.–S., and I.B. Weinstein. 1978. Uptake of the tumor–promoting agent12–0–tetradecanoylphorbol–l3–acetate by HeLa cells. J. Env. Pathol. Toxicol. 1: 627–639.

    CAS  Google Scholar 

  34. Jacobson, K., C.E. Wenner, G. Kemp, and D. Papahadjopoulos. 1975. Surface properties of phorbol esters and their interaction with lipid monolayers and bilayers. Cancer Res. 35: 2991–2995.

    PubMed  CAS  Google Scholar 

  35. Scribner, J.D., and R.K. Boutwell. 1972. Inflammation and tumor promotion: Selective protein induction in mouse skin by tumor promoters. Eur. J. Cancer 8: 617–621.

    Article  PubMed  CAS  Google Scholar 

  36. Thielmann, H.–W., and E. Hecker. 1969. Beziehungen zwischen der Struktur von PhorUnderlineerivaten und ihren entzündlichen und tumorpromovierenden Eigenschaften. In: Fortschr. d. Krebsforsch., VII. C.G. Schmidt and 0. Wetter,. Schattauer: New York. pp. 171–179.

    Google Scholar 

  37. Kubinyi, H. 1976. Quantitative structure–activity relationships IV. Nonlinear dependence of biological activity on hydrophobic character: A new model. Arzneim.Forsch. 26: 1991–1997.

    CAS  Google Scholar 

  38. Kreibich, G., and E. Hecker. 1970. On the active principles of croton oil. X: Preparation of tritium–labeled croton oil factor Al, and other tritium–labeled phorbol derivatives. Z. Krebsforsch. 74: 448–456.

    Article  PubMed  CAS  Google Scholar 

  39. Blumberg, P.M., P.E. Driedger, and P.W. Rossow. 1976. Effect of a phorbol ester on a transformation–sensitive surface protein of chick fibroblasts. Nature 264: 446–447.

    Article  PubMed  CAS  Google Scholar 

  40. Driedger, P.E., and P.M. Blumberg. 1979. Quantitative correlation between in vitro and in vivo activities of phorbol esters. Cancer Res. 39: 714–719.

    PubMed  CAS  Google Scholar 

  41. Driedger, P.E., and P.M. Blumberg. 1980. Structure–activity relationships in chick embryo fibroblasts for phorbolrelated diterpene esters showing anomalous activities in vivo. Cancer Res. 40: 339–346.

    PubMed  CAS  Google Scholar 

  42. Akera, T., T.M. Brody, and S.A. Wiest. 1979. Saturable adenosine 5–triphosphate–independent binding of [3H]ouabain to brain and cardiac tissue in vitro. Brit. J. Pharmacol. 65: 403–409.

    CAS  Google Scholar 

  43. Papazian, D., H. Rahamimoff, and S.M. Goldin. 1979. Reconstitution and purification by “transport specificity fractionation” of an ATP–dependent calcium transport component from synaptosome–derived vesicles. Proc. Natl. Acad. Sci. USA 76: 3708–3712.

    Article  PubMed  CAS  Google Scholar 

  44. Watterson, D.M., W.G. Harrelson, Jr., P.M. Keller, F. Sharief, and T.C. Vanaman. 1976. Structural similarities between the calcium-dependent regulatory proteins of 3’:5’-cyclic nucleotide phosphodiesterase and actomyosin ATPase. J. Biol. Chem. 251: 4501–4513.

    PubMed  CAS  Google Scholar 

  45. Catterall, W.A., C.S. Morrow, and R.P. Hartshorne. 1979. Neurotoxin binding to receptor sites associated with voltage–sensitive sodium channels in intact, lysed, and detergent–solubilized brain membranes. J. Biol. Chem. 254: 11379–11387.

    PubMed  CAS  Google Scholar 

  46. Nebert, D.W., W.F. Benedict, J.E. Gielen, F. Oesch, and J.W. Daly. 1972. Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12–dimethylbenz[a]anthracene–produced skin tumorigenesis in the mouse. Molec. Pharmacol. 8: 374–379.

    CAS  Google Scholar 

  47. Schmid, F.A., M.S. Demetriades, F.M. Schabel, III, and G.S. Tarnowski. 1967. Toxicity of several carcinogenic polycyclic hydrocarbons and other agents in AKR and C57BL/6 mice. Cancer Res. 27: 563–567.

    CAS  Google Scholar 

  48. Nebert, D.W., and N.M. Jensen. 1979. The Ah locus: Genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P–450–mediated monooxygenases. Crit. Rev. Biochem. 6: 401–437.

    Article  CAS  Google Scholar 

  49. Estensen, R.D., D.K. DeHoogh, and C.F. Cole. 1980. Binding of [3H]12–0–tetradecanoylphorbol–13–acetate to intact human peripheral blood lymphocytes. Cancer Res. 40: 1119–1124.

    PubMed  CAS  Google Scholar 

  50. Shoyab, M., and G.J. Todaro. 1980. Specific high–affinity cell membrane receptors for biologically active phorbol and ingenol esters. Nature 288: 451–455.

    Article  PubMed  CAS  Google Scholar 

  51. Dunphy, W.G., C.–C. Lau, and P.M. Blumberg. 1980. Phorbolrelated diterpene esters have similar structure–activity relationships in Swiss 3T3 cells and chicken embryo fibroblasts. Carcinogenesis 1: 347–351.

    Article  PubMed  CAS  Google Scholar 

  52. Bresch, H., and U. Arendt. 1978. Disturbances of early sea urchin development by the tumor promoter TPA (phorbol ester). Naturwissenschaften 65: 660–662.

    Article  PubMed  CAS  Google Scholar 

  53. Pabst, G., ed. 1883. Euphorbia Resinifera. In: MedizinalPflanzen, Volume 1. Fr. Eugen. Kohler Verlag. pp. 159.

    Google Scholar 

  54. Weber, J., and E. Hecker. 1978. Cocarcinogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curacao. Experientia 34: 679–682.

    Article  PubMed  CAS  Google Scholar 

  55. Morton, J.F. 1971. Welensali ( Croton flavens ): Folk uses and properties. Econ. Bot. 25: 457–463.

    Article  Google Scholar 

  56. Watt, J.M., and M.G. Breyer–Brandwijk. 1962. The Medicinal and Poisonous Plants of Southern and Eastern Africa. E. S. Livingstone, Ltd.: Edinburgh and London. p. 415.

    Google Scholar 

  57. Calkins, J. 1972. Tobacco smoke, carcinogens, and systems for recovery from DNA injury. Proceedings of the Third Tobacco and Health Workshop, University of Kentucky. pp. 214–231.

    Google Scholar 

  58. Kinghorn, A.D., K.K. Harjes, and N.J. Doorenbos. 1977. Screening procedure for phorbol esters using brine shrimp (Artemia salin) larvae. J. Pharmacol. Sci. 66: 1362–1363.

    Article  CAS  Google Scholar 

  59. Soper, C.J., and F.J. Evans. 1977. Investigations into the mode of action of the cocarcinogen 12–0–tetradecanoylphorbol–13–acetate using auxotrophic bacteria. Cancer Res. 37: 2487–2491.

    PubMed  CAS  Google Scholar 

  60. Barnes, R.D. 1980. Invertebrate Zoology. Saunders College: Philadelphia.

    Google Scholar 

  61. Potter, J.D., and J. Gergely. 1975. The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase. J. Biol. Chem. 250: 4628–4633.

    PubMed  CAS  Google Scholar 

  62. Piascik, M.T., P.L. Wisler, C.L. Johnson, and J.D. Potter. 1980. Ca++—dependent regulation of guinea pig brain adenylate cyclase. J. Biol. Chem. 255: 4176–4181.

    PubMed  CAS  Google Scholar 

  63. Kretsinger, R.H. 1976. Calcium–binding proteins. Ann. Rev. Biochem. 45: 239–266.

    Article  PubMed  CAS  Google Scholar 

  64. Osborne, R., and A.H. Tashjian, Jr. 1981. Tumor—promoting phorbol esters affect production of prolactin and growth hormone by rat pituitary cells. Endocrinology 108:1164–1170.

    Article  PubMed  CAS  Google Scholar 

  65. Lee, L.–S., and I.B. Weinstein. 1978. Tumor–promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors. Science 202: 313–315.

    Article  PubMed  CAS  Google Scholar 

  66. Shoyab, M., J.E. DeLarco, and G.J. Todaro. 1979. Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors. Nature 279: 387–391.

    Article  PubMed  CAS  Google Scholar 

  67. Hirsh, D. 1975. Patterns of gene expression. In: Microbiology–1975. D. Schlessinger, ed. American Society for Microbiology: Washington, DC. pp. 508–514.

    Google Scholar 

  68. Hirsh, D., D. Oppenheim, and M. Klass. 1976. Development of the reproductive system of Caenorhabditis elegans. Dev. Biol. 49: 200–219.

    Article  PubMed  CAS  Google Scholar 

  69. Hirsh, D., and R. Vanderslice. 1976. Temperature—sensitive developmental mutants of Caenorhabditis elegans. Develop. Biol. 49: 220–235.

    Article  PubMed  CAS  Google Scholar 

  70. Lew, K., and A. Kolber. (in press). An in vitro assay to screen for mutagens/carcinogens in the nematode C. elegans. In: In Vitro Toxicity Testing of Environmental Chemicals: Current and Future Possibilities. A. Kolber and T. Wong,. Plenum Press: New York.

    Google Scholar 

  71. Brenner, S. 1973. The genetics of behaviour. Brit. Med. Bull. 29: 269–271.

    PubMed  CAS  Google Scholar 

  72. Brenner, S. 1974. The genetics of Caenorhabditis elegans. Genetics 77: 71–94.

    PubMed  CAS  Google Scholar 

  73. Sulston, J., and R. Horvitz. 1977. Post—embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol. 56: 110–156.

    Article  PubMed  CAS  Google Scholar 

  74. Sulston, J., and S. Brenner. 1974. The DNA of Caenorhabditis elegans. Genetics 77: 95–104.

    PubMed  CAS  Google Scholar 

  75. Emmons, S., M. Klass, and D. Hirsh. 1979. Analysis of the constancy of DNA sequences during development and evolution of the nematode Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 79: 1333–1337.

    Article  Google Scholar 

  76. Driedger, P.E., and P.M. Blumberg. 1980. Different biological targets for resiniferatoxin and phorbol 12–myristate 13–acetate. Cancer Res. 40: 1400–1404.

    PubMed  CAS  Google Scholar 

  77. Horowitz, A.D., E. Greenebaum, and I.B. Weinstein. 1980. Identification and properties of phorbol ester receptors in rat embryo cells. J. Cell Biol. 87: 174a.

    Google Scholar 

  78. Scheinberg, D.A., and M. Strand. 1981. A brain membrane protein similar to the rat src gene product. Proc. Natl. Acad. Sci. USA 78: 55–59.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Peter M. Blumberg, K. Barry Delclos & Susan Jaken

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  1. Peter M. Blumberg
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  2. K. Barry Delclos
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  3. Susan Jaken
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Blumberg, P.M., Delclos, K.B., Jaken, S. (1983). Tissue and Species Specificity for Phorbol Ester Receptors. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_11

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_11

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