Abstract
Many types of carcinogens show pronounced differences in effect in different species, often inducing tumors of a certain site in one and being inactive in another. N-Nitroso compounds, on the other hand, are commonly carcinogenic in all species examined, but induce tumors of different cell types and in different organs from one species to the next. This variability is particularly true of nitrosamines, whose organ and species specificity are probably due to differences in routes of metabolism and activation. These differences are open to study using biochemical and chemical methods and should afford a means of approaching an understanding of the mechanisms of nitrosamine carcinogenesis.
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References
Bartsch, H., C. Malaveille, and R. Montesano. 1975. In vitro metabolism and microsome-mediated mutagenicity of dialkyl nitrosamines in rat, hamster, and mouse tissues. Cancer Res. 35: 644–651.
Lijinsky, W., H. Garcia, L. Keefer, and J. Loo. 1972. Carcinogenesis and alkylation of rat liver nucleic acids by nitrosomethylurea and nitrosoethylurea administered by intraportal injection. Cancer Res. 32: 893–897.
Lijinsky, W., and H.W. Taylor. 1976. Carcinogenesis in Sprague-Dawley rats of N-nitroso-N-alkylcarbamate esters. Cancer Lett. 1: 275–279.
Lijinsky, W., and C. Winter. (in press). Skin tumors induced by painting nitrosoalkylureas on mouse skin. Cancer Res. Clin. Oncol.
Takayama, S., N. Kuwabara, Y. Azama, and T. Sugimura. 1971. Skin tumors in mice painted with N-methyl-N’-nitro-Nnitrosoguanidine and N-ethyl-N’-nitro-N-nitrosoguanidine. J. Natl. Cancer Inst. 46: 973–980.
Okada, M., and M. Ishidate. 1977. Metabolic fate of N-n-butyl-N-(4-hydroxybutyl) nitrosamine and its analogues. Xenobiotica 7: 11–24.
Lijinsky, W., and M.D. Reuber. 1981. Carcinogenic effect of nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine in Fischer rats. Cancer Lett. 12: 99–103.
Lijinsky, W., H.W. Taylor, and L.K. Keefer. 1976. Reduction of rat liver carcinogenicity of nitrosomorpholine by alpha deuterium substitution. J. Natl. Cancer Inst. 57: 1311–1313.
Rao, T.K., J.A. Young, W. Lijinsky, and J.L. Epler. 1979. Mutagenicity of aliphatic nitrosamines in Salmonella typhimurium. Mutat. Res. 66: 1–9.
Druckrey, H., R. Preussmann, S. Ivankovic, and D. Schmähl. 1967. Organotrope Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch. 69: 103–201.
Okada, M., E. Suzuki, and M. Mochizuki. 1976. Possible important role of urinary N-methyl-N-(3-carboxypropyl)-nitrosamine in the induction of bladder tumors in rats by N-methyl-n-dodecylnitrosamine. Gann 67: 771–772.
Lijinsky, W., J.E. Saavedra, and M.D. Reuber. (in press). Carcinogenesis in Fischer rats by methylalkylnitrosamines. Cancer Res.
Althoff, J., and W. Lijinsky. 1977. Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine. Z. Krebsforsch. 90: 227–231.
Ketkar, M.B., J. Althoff, and W. Lijinsky. 1981. The carcinogenic effect of nitrosomethyldodecylamine in European hamsters. Cancer Lett. 13: 165–168.
Cardy, R.H., and W. Lijinsky. 1980. Comparison of the carcinogenic effects of five nitrosamines in guinea pigs. Cancer Res. 40: 1879–1884.
Lijinsky, W., M.D. Reuber, and B.N. Blackwell. 1980. Carcinogenicity of nitrosotrialkylureas in Fischer rats. J. Natl. Cancer Inst. 65: 451–453.
Lijinsky, W., M.D. Reuber, and W.B. Manning. 1980. Potent carcinogenicity of nitrosodiethanolamine in rats. Nature 288: 589–590.
Hilfrich, J., I. Schmeltz, and D. Hoffman. 1978. Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters. Cancer Lett. 4: 55–60.
Preussmann, R., G. Wurtele, G. Eisenbrand, and B. Spiegelhalder. 1978. Urinary excretion of N-nitrosodiethanolamine administered orally to rats. Cancer Lett. 4: 207–209.
Lijinsky, W., and H.W. Taylor. 1975. Increased carcinogenicity of 2,6-dimethylnitrosomorpholine compared with nitrosomorpholine in rats. Cancer Res. 35: 2123–2125.
Lijinsky, W., and M.D. Reuber. 1980. Comparison of carcinogenesis by two isomers of nitroso-2,6-dimethylmorpholine. Carcinogenesis 1: 501–503.
Rao, M.S., D.G. Scarpelli, and W. Lijinsky. (in press). Carcinogenesis in Syrian hamsters by N-nitroso-2,6-dimethylmorpholine, its cis and trans isomers, and the effect of deuterium labeling. Carcinogenesis.
Lijinsky, W., and M.D. Reuber. 1981. Comparative carcinogenicity of two isomers of nitroso-2,6-dimethymorpholine in guinea pigs. Cancer Lett. 14: 7–11.
Lijinsky, W., J.E. Saavedra, M.D. Reuber, and B.N. Blackwell. 1980. The effect of deuterium labeling on the carcinogenicity of nitroso-2,6-dimethylmorpholine in rats. Cancer Lett. 10: 325–331.
Gingell, R., L. Wallcave, D. Nagel, R. Kupper, and P. Pour. 1976. Common metabolites of N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine in the Syrian hamster. Cancer Lett. 2: 47–52.
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© 1983 Plenum Press, New York
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Lijinsky, W. (1983). Species Specificity in Nitrosamine Carcinogenesis. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_4
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_4
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