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Organ and Species Specificity in Nickel Subsulfide Carcinogenesis

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Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

The carcinogenic effects of metal compounds in man and experimental animals have been comprehensively reviewed in several recent articles and monographs (1-7). Four metals (arsenic, cadmium, chromium, and nickel) have been established as human carcinogens on the basis of epidemiological investigations, and compounds of 13 metals (aluminum, beryllium, cadmium, cobalt, chromium, copper, iron, manganese, nickel, lead, platinum, titanium, and zinc) have been shown to induce cancers in experimental animals (5-7). Nickel subsulfide (Ni3S2) is the most potent metallic carcinogen that has been identified to date;Ni3S2 has been evaluated for carcinogenicity much more thoroughly and extensively than any other metal compound (3,8-10). Consequently, Ni3S2 has been selected as the focal point for this exposition of organ and species specificity in metal carcinogenesis.

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Author information

Authors and Affiliations

  1. Departments of Laboratory Medicine and Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut, 06032, USA

    F. William Sunderman Jr.

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  1. F. William Sunderman Jr.
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Editor information

Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Sunderman, F.W. (1983). Organ and Species Specificity in Nickel Subsulfide Carcinogenesis. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_6

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

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